In a retrospective study of 408 patients with Peyronie's disease 8 (1.9%) patients gave a positive family history for the condition. Sixty-three (15.4%) patients had a Dupuytren's contracture and trauma was considered to be an aetiological factor in 88 (21.5%) patients. One hundred and twenty-two (29.9%) patients had evidence of atherosclerosis and this is thought to be a factor in the pathogenesis of the disease. Peyronie's disease is not a single disease entity and is associated with many aetiological factors.
The aetiology of retroperitoneal fibrosis is unknown.From time to time different drugs have been suggested as a cause, including beta adrenoceptor blocking agents. The notes of 100 hospital inpatients in whom retroperitoneal fibrosis had been diagnosed were surveyed to identify the date of onset of symptoms, the drugs prescribed before then, and the blood pressures on admission. Seventy one patients had diastolic pressures on admission of 90 mm Hg or more and 53 of these had pressures of at least 100 mm Hg despite 14 of the patients taking antihypertensive drugs at the time. Six patients had received beta-adrenoceptor blocking agents before the onset of symptoms and a further 24 received them subsequently. In particular, three patients continued treatment for at least six years after the diagnosis was made and surgery performed, without suffering a recurrence of retroperitoneal fibrosis.Besides beta-adrenoceptor drugs, diuretics and other hypotensive drugs were taken in amounts reflecting the
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