The association between Peyronie's and Dupuytren's disease

Introduction Peyronie’s disease (PD) is progressive fibrotic disorder of the penile tunica albuginea that results in fibrotic penile plaques and may lead to penile deformity. Characterized by aberrant fibrosis resulting in part from persistence of myofibroblasts as well as altered gene expression, the molecular factors underpinning Peyronie’s disease and other related fibrotic diatheses are just being elucidated. A genetic link to PD was first identified using pedigree analyses three decades ago. However, the specific genetic factors that predispose patients to aberrant fibrosis remain unknown, and the relationships between these fibrotic conditions and other heritable diseases, including malignancy, are uncharacterized. Aim To review the current landscape linking molecular and genetic factors to aberrant fibrosis in PD as well as related fibrotic diatheses, including Dupuytren’s disease. Methods Review and evaluation of the literature from 1970 to present examining the genetic factors associated with PD. Main Outcome Measures Data describing the genetic factors associated with PD. Results We describe the known structural chromosomal abnormalities and single nucleotide polymorphisms associated with fibrotic diatheses, and discuss the spectrum of differential gene expression data comparing normal tissues and those derived from men with Peyronie’s or Dupuytren’s diseases. Finally, we discuss epigenetic mechanisms that may regulate gene expression and alter predisposition to fibrosis. Conclusion Although our current understanding of the genetic factors associated with PD are limited, significant advances have been made over the last three decades. Further research is necessary to provide a more comprehensive understanding of the landscape of genetic factors responsible for the development of PD.

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“…7–9 Concurrent fibrotic syndromes can be seen within the same individual, with 10–20% of men with PD also manifesting DD. 7 …”

Section: Introductionmentioning

confidence: 99%

The Genetic Basis of Peyronie Disease: A Review

Herati

Pastuszak

2016

Sexual Medicine Reviews

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“…The association of Dupuytren and Peyronie disease was revisited by Nugteren et al 25 in a study of 415 men with Peyronie disease. Each patient with Peyronie disease was also examined specifically for findings of Dupuytren nodules and cords.…”

Section: Dupuytren and Peyronie Diseasementioning

confidence: 98%

Evidence-Based Medicine

Eaton

2014

Plastic and Reconstructive Surgery

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The large body of existing literature on Dupuytren disease is spread across many journals in many specialties. It is thus a daunting task for practitioners to follow trends and practice recommendations. It is also a testimony to the lack of an acceptable solution to this common problem. Recent publications provide evidence to highlight controversies and challenge some traditional teachings. Literature from 2010 to 2012 was reviewed with the intent of clarifying some of these issues.

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“…Peyronie's disease is known to be associated with Dupuytren's disease [34]. Main characteristic of the Dupuytren's disease is palmar aponeurosis hyperplasy and contraction which leads to finger flexion contracture [35].…”

Section: Pathophysiologymentioning

confidence: 99%