Facile Synthesis, Antimicrobial Activity and Molecular Docking of Novel 2,4,5‐Trisubstituted‐1<i>H</i>‐Imidazole–Triazole Hybrid Compounds

Chauhan, Sunil; Verma, Vikas; Kumar, Devinder; Kumar, Ashwani

doi:10.1002/jhet.3655

Cited by 7 publications

(9 citation statements)

References 32 publications

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“…The synthesized imidazole-triazole compounds were screened in vitro to study the antimicrobial activity. Activity against S.epidermis and E. Coli was confirmed [17].…”

Section: Antibacterial Effectmentioning

confidence: 82%

Review of pharmacological effects of imidazole derivatives

et al. 2022

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Imidazole derivatives are the perspective class of drugs with a broad spectrum of application in medicine. Imidazole is a nitrogen-containing heterocyclic ring; it has two equivalent forms; hydrogen atom may be located on any of two nitrogen atoms. Imidazole ring may interact with various cations and anions, as well as with biomolecules by different reactions; the presence of various groups in the nitrogenous heterocycle structure makes it possible to identify substances with a broad spectrum of pharmacological effects. They are very important for the production of new drugs and recently draw the special interest of scientists due to their properties in the chemistry and pharmacology. Introduction of highly active Imidazole has stimulated the significant achievements in the field of chemotherapeutic agents and plays the very important role in medicine. Therefore, the active search for highly active Imidazole compounds still continues. This article describes the antifungal and antibacterial effects identified in preclinical studies through a literature review. The purpose of this work is to review the principal effects of Imidazole published in the scientific literature in recent years.

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“…The synthesized imidazole-triazole compounds were screened in vitro to study the antimicrobial activity. Activity against S.epidermis and E. Coli was confirmed [17].…”

Section: Antibacterial Effectmentioning

confidence: 82%

Review of pharmacological effects of imidazole derivatives

et al. 2022

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“…The MIC value of ciprofloxacin against all four bacterial strains tested was 4.7 µM. It was also found that hybrid 287e was anchored in the binding site of DNA gyrase topoisomerase II of E. coli [178].…”

Section: 23-and 124-triazole/imidazole Hybrids and Conjugatesmentioning

confidence: 85%

“…As regards the synthetic methodologies used in these studies, it is worth noting that multicomponent condensation reactions, a class of benign processes that are characterised by experimental simplicity and low cost, have frequently been used for the synthesis of a variety of hybrids and conjugates [9,93,97,145,164,166,[176][177][178]219,220,232,237], and that such processes [250][251][252][253] as well as several other condensation reactions have often been preferentially carried out using microwave (MW)-promoted reactions instead of conventional heating sources [254][255][256][257][258]. In fact, as often highlighted by the published data, the advantages of microwave-promoted reactions [93,144,166,177,219,232] include significant shorter reaction times, higher yields, and product purity when compared to conventional thermal methods.…”

Section: Discussionmentioning

confidence: 99%

“…Even copper(I)-catalysed alkyne-azide cycloadditions [258,259] have been frequently employed for the efficient introduction of a 1,2,3-triazole moiety into the desired imidazole hybrids and conjugates [32,59,177,178]. On the other hand, classical Pd-catalysed Suzuki-type reactions have only Compounds 428 and 431 were then evaluated for their antibacterial activity against Gram-positive S. aureus MTCC 96 and B. subtilis MTCC 2451, and Gram-negative E. coli MTCC 82 and P. aeruginosa MTCC 2642.…”

Section: Discussionmentioning

confidence: 99%

“…Nine 1,2,3-triazole-substituted naphthaldehydes 288 were in turn prepared in 87-92% yield by treating 2-(prop-2-yn-1-yloxy)-1-naphthaldehyde (289) with the appropriate aryl azides 290, 10 mol% CuSO4•5H2O, and 20 mol% sodium ascorbate in a 4:1 mixture of DMF and water at 45 °C for 5-8 h (Scheme 57) [178].…”

Section: 23-and 124-triazole/imidazole Hybrids and Conjugatesmentioning

confidence: 99%

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An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety

Rossi

Ciofalo

2020

Molecules

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The rapid growth of serious infections caused by antibiotic resistant bacteria, especially the nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists and is one of the world’s major health problems. Various strategies have been and are currently investigated and developed to reduce and/or delay the bacterial resistance. One of these strategies regards the design and development of antimicrobial hybrids and conjugates. This unprecedented critical review, in which our continuing interest in the synthesis and evaluation of the bioactivity of imidazole derivatives is testified, aims to summarise and comment on the results obtained from the end of the 1900s until February 2020 in studies conducted by numerous international research groups on the synthesis and evaluation of the antibacterial properties of imidazole-based molecular hybrids and conjugates in which the pharmacophoric constituents of these compounds are directly covalently linked or connected through a linker or spacer. In this review, significant attention was paid to summarise the strategies used to overcome the antibiotic resistance of pathogens whose infections are difficult to treat with conventional antibiotics. However, it does not include literature data on the synthesis and evaluation of the bioactivity of hybrids and conjugates in which an imidazole moiety is fused with a carbo- or heterocyclic subunit.

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1,2,3‐Triazole Derivatives as an Emerging Scaffold for Antifungal Drug Development against Candida albicans: A Comprehensive Review

Singh

Sharma

et al. 2023

Chemistry & Biodiversity

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Candida infections are most prominent among fungal infections majorly target immunocompromised and hospitalized patients and cause significant morbidity and mortality. Candida albicans is the notorious and most prevalent among all pathogenic Candida strains. Its emerging resistance toward available antifungal agents making it hard to tackle and emerging as global healthcare emergency. Simultaneously, 1,2,3-triazole nucleus is a privileged scaffold that is gaining importance in antifungal drug development due to being a prominent bioactive linker and isostere of triazole based antifungal class core 1,2,4-triazole. Numerous reports have been updated in scientific literature in last few decades related to utilization of 1,2,3-triazole nucleus in antifungal drug development against Candida albicans. Present review will shed light on various preclinical studies focused on development of 1,2,3-triazole derivatives targeting Candida albicans along with brief highlight on clinical trials and newly approved drugs. Structure-activity relationship has been precisely discussed for each architect along with future perspective that will help medicinal chemists in design and development of potent antifungal agents for tackling infections derived from Candida albicans.

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Facile Synthesis, Antimicrobial Activity and Molecular Docking of Novel 2,4,5‐Trisubstituted‐1H‐Imidazole–Triazole Hybrid Compounds

Cited by 7 publications

References 32 publications

Review of pharmacological effects of imidazole derivatives

Review of pharmacological effects of imidazole derivatives

An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety

1,2,3‐Triazole Derivatives as an Emerging Scaffold for Antifungal Drug Development against Candida albicans: A Comprehensive Review

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