Fabrication of Antibacterial Nanofibers Composites by Functionalizing the Surface of Cellulose Acetate Nanofibers

Abstract

The surface modification of nanofibers web enables the invention of wound dressings by using the simple materials substrate without altering the mechanical properties of foundation materials or nanofibers web. Herein, authors fabricated the novel antibacterial wound dressings by functionalizing the surface of cellulose acetate (CA) nanofibers. This surface treatment was done through facile method. The silver sulfadiazine (SSD) nanoparticles were successfully synthesized on the surface of cellulose acetate nanofibers web by in-situ facile method in which nanofibers webs were immersed in the solution of sodium sulfadiazine salt and silver nitrate (AgNO 3 ) for three different interval of times (hrs). The resultant CA/SSD nanofibers were characterized by scan electron microscope, transmission electron microscope, FT-IR, XPS, XRD, water contact angle and antibacterial agar disc diffusion test. All characterization results supported that this composite can be used for antibacterial wound dressings, especially for gram negative E. Coli bacteria because SSD has great potential against E. Coli bacteria.[a] Dr.

Tailoring the Surface Properties of Micro/Nanofibers Using 0D, 1D, 2D, and 3D Nanostructures: A Review on Post‐Modification Methods

“…The strategy is considered simple, fast, cheap, scalable, versatile, performed at atmospheric conditions, and carried out in one or more steps to modify the target surface with polymers and nanoparticles. [ 139–141 ] The surface modification can be tailored mainly through the concentration of the solution and the immersion time. [ 142 ] This method allows the functionalization of nano‐/microfibers with distinct nanostructures as Co 3 O 4, [ 143 ] AgNWs, [ 144 ] TiO 2 , [ 145,146 ] SiO 2 , [ 147 ] Al 2 O 3 , [ 148 ] ZnO, [ 132,149 ] AgPO 4, [ 150 ] AgNPs, [ 151,152 ] graphene oxide, [ 153 ] reduced graphene oxide (rGO), [ 154 ] CNW(cellulose nanowhiskers):Ag, [ 155 ] CNW:Au, [ 156 ] sugarcane bagasse fly ash (SBFA), [ 157 ] MWCNTs, [ 158 ] and AgNPs/rGO.…”

A Multifunctional Janus Electrospun Nanofiber Dressing with Biofluid Draining, Monitoring, and Antibacterial Properties for Wound Healing

“…Electrospun composite membrane , is a facile and economical material for tissue engineered stents, drug delivery, anti-infective therapy, chronic wound treatment, − and skin regeneration . This kind of composite membrane has unique properties, such as high specific surface area, high porosity, air permeability, and extracellular-matrix-mimicking structure. − Thus, various synthetic and natural polymers are utilized as elecrospun wound dressings, − which can absorb wound exudates, maintain wound-site moisture, and prevent microbial invasion. − Among the polymers, polylactide (PLA) polymer has been approved by the Food and Drug Administration (FDA) for drug delivery. The elecrospun nanofibers prepared by PLA possess a good capability for local delivery therapeutic agents to skin wound sites. − Moreover, antibacteria is one of the key issues for skin injuries because the bacterial infection would inevitably prolong wound healing time. , Thus, it is of great clinical significance to the synthesis of wound dressings with antibacterial activity.…”

Green Synthesis and Incorporation of Sericin Silver Nanoclusters into Electrospun Ultrafine Cellulose Acetate Fibers for Anti-Bacterial Applications

“…Recently, safe and advanced non-woven nanofibrous dressings have received tremendous attention in antibacterial applications [ 23 ]. It is also stated that nanofibers have remarkable properties such as high interconnected porosity, large surface area to volume ratios [ 24 , 25 ].…”