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The fabrication of artificial blood vessel remains an ongoing challenge for cardiovascular tissue engineering. Full biocompatibility, proper physiological, and immediate availability have emerged as central issues. To address these issues, the dual-network composite scaffolds were fabricated by coating the electrospun nanofibers-based tubes with poly(vinyl alcohol) (PVA) hydrogel, which could increase the cell viability and show the potential for controlling the composition, structure, and mechanical properties of scaffolds. Herein, the tubular scaffolds having an inner diameter of 2 mm, were composed with poly(1,4 cyclohexane dimethylene isosorbide terephthalate)/PVA. The morphology examination showed that tubular structure was dimensionally stable and suitable for an artificial blood vessel. Fourier transform infrared spectra, wetting behavior, stress-strain behavior, and Thiazolyl Blue Tetrazolium Bromide (3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide) analysis also showed that the composite scaffolds have good chemical interactions between poly(1,4 cyclohexane dimethylene isosorbide terephthalate) (PICT) and PVA, blended PICT/PVA tubes showed the appropriate wetting behavior, it achieved the appropriate breaking strength and adequate pliability up to 47.5% and in vitro assessment showed that blended PICT/PVA scaffolds have the appropriate cell viability and nontoxic, respectively. On the basis of characterizations results, it was concluded that resultant scaffolds would be addressed to fulfill the requirements such as biocompatibility, dimensional stability, adequate elongation, breaking strength, immediate availability, and proper for physiologically.

The surface modification of nanofibers web enables the invention of wound dressings by using the simple materials substrate without altering the mechanical properties of foundation materials or nanofibers web. Herein, authors fabricated the novel antibacterial wound dressings by functionalizing the surface of cellulose acetate (CA) nanofibers. This surface treatment was done through facile method. The silver sulfadiazine (SSD) nanoparticles were successfully synthesized on the surface of cellulose acetate nanofibers web by in-situ facile method in which nanofibers webs were immersed in the solution of sodium sulfadiazine salt and silver nitrate (AgNO 3 ) for three different interval of times (hrs). The resultant CA/SSD nanofibers were characterized by scan electron microscope, transmission electron microscope, FT-IR, XPS, XRD, water contact angle and antibacterial agar disc diffusion test. All characterization results supported that this composite can be used for antibacterial wound dressings, especially for gram negative E. Coli bacteria because SSD has great potential against E. Coli bacteria.[a] Dr.