Fabrication and in vitro evaluation of novel <scp>pH</scp>‐sensitive poly (2‐methoxyethyl methacrylate‐co‐itaconic acid) microgels

Rashid, Zermina; Ranjha, Nazar Muhammad; Razzaq, Rabia; Raza, Hina

doi:10.1002/adv.21786

Cited by 10 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In pH 6.8, all samples containing IA exhibited an increase in the drug release compared to samples tested in pH 2.2. This may be due to the higher degree of swelling due to the ionisation of carboxylic groups of IA in the hydrogel networks at pH 6.8 [6,29]. It was also found that the samples with the higher concentration of IA showed greater drug release in pH 6.8.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly (N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Fallon

Halligan

Pezzoli

et al. 2019

Gels

View full text Add to dashboard Cite

Previous studies involving poly N-vinylcaprolactam (PNVCL) and itaconic acid (IA) have synthesised the hydrogels with the presence of a solvent and a crosslinker, producing chemically crosslinked hydrogel systems. In this study, however, temperature sensitive PNVCL was physically crosslinked with a pH-sensitive comonomer IA through ultraviolet (UV) free-radical polymerization, without the presence of a solvent, to produce hydrogels with dual sensitivity. The attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy indicated successful polymerisation of the hydrogels. The temperature and pH sensitivity of the hydrogels was investigated. The lower critical solution temperature (LCST) of the gels was determined using the UV spectrometry and it was found that the incorporation of IA decreased the LCST. Rheology was conducted to investigate the mechanical and viscoelastic properties of the hydrogels, with results indicating IA that enhances the mechanical properties of the gels. Swelling studies were carried out at ~20 °C and 37 °C in different buffer solutions simulating the gastrointestinal tract (pH 2.2 and pH 6.8). In acidic conditions, the gels showed gradual increase in swelling while remaining structurally intact. While in basic conditions, the gels had a burst in swelling and began to gradually degrade after 30 min. Results were similar for drug release studies. Acetaminophen was incorporated into the hydrogels. Drug dissolution studies were carried out at 37 °C in pH 2.2 and pH 6.8. It was found that <20% of acetaminophen was released from the gels in pH 2.2, whereas the maximum drug released at pH 6.8 was 74%. Cytotoxicity studies also demonstrated the hydrogels to be highly biocompatible. These results indicate that physically crosslinked P(NVCL-IA) gels possess dual pH and temperature sensitive properties, which may be beneficial for biomedical applications such as drug delivery.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly (N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Fallon

Halligan

Pezzoli

et al. 2019

Gels

View full text Add to dashboard Cite

show abstract

“…By switching between charged and uncharged states depending on the solution pH, these monomers govern the microgel's swelling by promoting electrostatic repulsion among the chains and forming hydrogen bonds with water. [142][143][144][145] For example, Li et al sandwiched AA-containing microgels between thin films and utilized the pH-induced microgel swelling to vary the distance between the films. [33] Giraud et al explored the effects of charge and inter-particle spacing on the sliding friction between sheets of pH-responsive P(S-co-AA) microgels.…”

Section: Ph-responsive Monomersmentioning

confidence: 99%

Surface‐Bound Microgels for Separation, Sensing, and Biomedical Applications

Cutright

Harris

Ramesh

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

This study presents a comprehensive survey of microgel-coated materials and their functional behavior, describing the complex interplay between the physicochemical and mechanical properties of the microgels and the chemical and morphological features of substrates. The cited literature is articulated in four main sections: i) properties of 2D and 3D substrates, ii) synthesis, modification, and characterization of the microgels, iii) deposition techniques and surface patterning, and iv) application of microgel-coated surfaces focusing on separations, sensing, and biomedical applications. Each section discussesby way of principles and examples -how the various design parameters work in concert to deliver functionality to the composite systems. The case studies presented herein are viewed through a multi-scale lens. At the molecular level, the surface chemistry and the monomer make-up of the microgels endow responsiveness to environmental and artificial physical and chemical cues. At the micro-scale, the response effects shifts in size, mechanical, and optical properties, and affinity towards species in the surrounding liquid medium, ranging from small molecules to cells. These phenomena culminate at the macro-scale in measurable, reversible, and reproducible effects, aiming in a myriad of directions, from lab-scale to industrial applications.

show abstract

“…The drug release kinetics was obtained by fitting the drug release data to zero order, first order, Higuchi model and Hixson Crowell [18,19]. Korsmeyer and Peppas equation (equation (9)) was applied to interpret the mechanism of drug release from the microparticles.…”

Section: Release Kinetic Studiesmentioning

confidence: 99%

Sustained released Metformin microparticles for better management of type II diabetes mellitus: in-vitro studies

Raza

Javeria

Rashid

2020

Mater. Res. Express

Self Cite

View full text Add to dashboard Cite

This work investigates Ethyl cellulose (EC) and polyethylene glycol (PEG) microparticles for prolonged delivery of Metformin HCl.The microparticles were synthesised by emulsion solvent evaporation technique; characterized for encapsulation efficiency, particle size, flow properties, surface morphology, FTIR, PXRD and drug release pattern; and investigated for the effect of formulation parameters like EC:PEG ratio, drug to polymers ratio and stirring speed on various properties of the microparticles. The drug entrapment efficiency, percent yield, particle size and drug release behaviour were found to be influenced by various formulation parameters.SEM images and size analysis confirmed formation of spherical shaped microparticles, with slightly rough surface and good flowability. FTIR revealed absence of any drug-polymer interaction and PXRD confirmed the molecular dispersion of drug with in microparticles. All the formulations showed sustained drug release pattern at pH 6.8, up to 91.34% ±1.68 metformin was released in 12 h with fickian diffusion mechanism. The designed microparticles could possibly be advantageous in terms of prolonged release, to achieve reduced dose frequency and improved patient compliance.

show abstract

Fabrication and in vitro evaluation of novel pH‐sensitive poly (2‐methoxyethyl methacrylate‐co‐itaconic acid) microgels

Cited by 10 publications

References 41 publications

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly (N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly (N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Surface‐Bound Microgels for Separation, Sensing, and Biomedical Applications

Sustained released Metformin microparticles for better management of type II diabetes mellitus: in-vitro studies

Contact Info

Product

Resources

About