Extramedullary myeloid tumors in primary myelofibrosis

Lieberman, Philip; Rosvoll, Randi V.; Ley, Allyn B.

doi:10.1002/1097-0142(196506)18:6<727::aid-cncr2820180610>3.0.co;2-8

Cited by 78 publications

(30 citation statements)

References 21 publications

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“…Among chronic myeloproliferative disorders, EMH is most commonly seen in idiopathic MF since it is associated with the highest rate of bone marrow fibrosis (up to 80 % at presentation) and circulating progenitor cells [5,6]. Foci of EMH are most commonly found in the spleen, liver and lymph nodes, but may also infrequently occur at other sites as kidney, adrenal glands, pleura and peritoneum [7][8][9][10][11]. Skin and cardiac manifestations, as we have encountered in our patient, are extremely rare.…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Extramedullary Hematopoiesis in Post-polycythemic Myelofibrosis

Değertekin

Akyürek

Yağcı

2012

Indian J Hematol Blood Transfus

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Polycythemia vera is a clonal proliferative disorder of the bone marrow that could possibly evolve into myelofibrosis in its natural course. Progression to myelofibrosis is usually a late stage complication and presents clinically with refractory cytopenias and extramedullary hematopoiesis (EMH). EMH can occur in any tissue during the course of post-polycythemic myelofibrosis. However, skin and cardiac involvements seems to be very rare. We present a 56-year-old woman with post-polycythemic myelofibrosis refractory to treatment, developing EMH after splenectomy in various organs, exceptionally the skin and the heart. Along with the case, the clinical presentations, treatment options, prognostic significance of EMH and the role of cytogenetics is discussed in the light of the literature.

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Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Extramedullary Hematopoiesis in Post-polycythemic Myelofibrosis

Değertekin

Akyürek

Yağcı

2012

Indian J Hematol Blood Transfus

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“…In these cases, the transforma- Myeloid tumor as a result of extramedullary hematopoiesis has been observed in various organs, such as spleen, liver, lymph nodes, kidney, adrenal gland, peritoneum and so on (1)(2)(3). In all these cases, histologic examination using needle biopsy is a useful diagnostic tool except in the case of splenic tumor, where the procedure carries the risk of hemorrhagic complications.…”

Section: Discussionmentioning

confidence: 99%

“…However, its manifestation as a splenic tumor is rare (1)(2)(3)(4). Here, we report a case of myelofibrosis (Mf) whopresented a space-occupying lesion in her spleen as a result of extramedullary hematopoiesis.…”

Section: Introductionmentioning

confidence: 97%

Tumor-like Splemic Extramedullary Hematopoiesis in a Patient with Myelofibrosis.

Yokoyama¹,

Saigo

Maeda³

et al. 2000

Intern. Med.

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A 61-year-old woman, who was diagnosed in 1982 as having polycythemia vera, was admitted to our hospital in July 1998 because of a splenic tumor in an enlarged spleen due to myelofibrosis. As it was difficult to identify the etiology of the splenic tumor, partial splenectomy was carried out. The resected tumor proved to be an extremely proliferative lesion as the result of extramedullary hematopoiesis. Since it is difficult to diagnose the etiology of splenic tumor, the collection and analysis of reports of relevant cases may well facilitate diagnosis. (Internal Medicine 39: 416-418, 2000)

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“…At necropsy the findings were those of chronic myeloid leukaemia only-the cervical nodes having been shrunken by radiotherapy. The diagnosis of two disorders of this type presents some difficulties; lymph nodes showing apparently typical changes of reticulum cell sarcoma may yield Ph1 positive cells (Carbone, 1966) and extramedullary tumours which resemble reticulum cell sarcoma may occur in states of myeloid metaplasia (Lieberman, Rosvall & Ley, 1965). In some cases the progression has shown cytological features of 'la remontee cellulaire evolutif' described by Bessis (e.g.…”

Section: Discussionmentioning

confidence: 99%