Lymphosarcoma during the course of myeloid leukaemia

Reticulum Cell Sarcoma in Waldenström's Macroglobulinemia After Chlorambucil Treatment

“…by Lortholary et al (9). A similar development seems to be a possibility in chronic myelocytic leukemia (19). Change in an anaplastic direction may also occur in multiple myeloma (e.g.…”

Ph-negative non-Hodgkin's lymphoma occurring in chronic phase of Ph-positive chronic myelogenous leukemia is defined as a genetically different neoplasm from extramedullary localized blast crisis: report of two cases and review of the literature

“…Although cases with lymph node enlargement in patients with CML have been described following the first report by Frank et al 5 and reviewed, 6,7 it is difficult to determine whether the blast cells are derived from the lymphoid or myelo-monocytoid lineages based only on morphology and cytochemistry. With the development of immunologic and molecular methods in the early 1980s, the cell of origin of extramedullary transformation of CML can generally be determined both in nodal and extranodal sites.…”

“…Extramedullary blast crisis of Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML) is infrequent (4.0%, 1 4.5%, 2 7.9% 3 and 4% 4 ), and the commonly affected sites are bone (37-57%), lymph node (17-29%), skin and soft tissue (14-29%), and central or peripheral nervous system (12-83%). Although cases with lymph node enlargement in patients with CML have been described following the first report by Frank et al 5 and reviewed, 6,7 it is difficult to determine whether the blast cells are derived from the lymphoid or myelo-monocytoid lineages based only on morphology and cytochemistry.…”

Sudden Extramedullary Blast Crisis of Chronic Myeloid Leukemia Manifesting as T-Cell Lymphoblastic Lymphoma

“…The incidence of extramedullary disease during the course of CML is reported to lie between 3 and 8% [5,6]. The earliest cases with lymph node enlargement in patients with CML were documented in 1968 [7]. It has always been difficult to determine whether the blast cells are derived from the lymphoid or the myelo-monocytoid lineages based solely on morphology and cytochemistry.…”