Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice

Abstract

Oxidative stress has a central role in the progression of diabetes mellitus (DM), which can directly result in the injury of islet β cells and consequent hyperglycemia. The aim of the present study was to evaluate the possible protective effects of black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE) on streptozotocin-induced DM mice. Oxidative stress was assessed by the levels of total antioxidative capability and glutathione in the serum. Fasting blood glucose and insulin levels, as well as the pancreas weight index and the histological changes in the pancreas, were also determined. The results showed that, after fours weeks of treatment with PPE, BBPE or PPE + BBPE, DM mice showed, to different degrees, a decrease in blood glucose, increases in insulin secretion and the pancreas weight index, and an increase in antioxidative activity. These changes were particularly evident in the DM mice subjected to the combined intervention strategy of PPE + BBPE. The histological findings indicated that the injury to the pancreatic islets in DM mice was also ameliorated following treatment. In conclusion, PPE and BBPE, particularly the combination of the two, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress-induced pancreatic damage; this finding may be useful in the prevention and treatment of DM.

Antioxidant, Antimicrobial and Urease Inhibitory Activities of Phenolics-Rich Pomegranate Peel Hydro-Alcoholic Extracts

“…Advanced research on PoP and its extracts primarily focuses upon suppression of oxidative stress in tissues and food systems (Bopitiya and Madhujith ; Wang et al . ). Likewise, numerous studies have shown that PoPx to exhibit ameliorative effects against oxidative stress, injuries in pancreatic islets, liver, skeletal muscles, colon mucosa tissues, cerebral ischemia induced brain injuries and platelet aggregation (Ahmed et al .…”

“…; Wang et al . ). Increasing trends in ethnopharmacological application of PoPx are also attributed to their minimal cytotoxic effects at relatively higher doses, that is ∼5000 mg/kg body weight (Reddy et al .…”

“…Despite the lack of worldwide consumption of PoP as a food material, it has been found to possess substantial biological potential against various major syndromes including inflammatory disorders, various types of cancer, cardiovascular diseases, type 2 diabetes and microbiological as well as parasitic infections (Zahin et al 2010;Ismail et al 2012;Mo et al 2013;Malviya et al 2014). Advanced research on PoP and its extracts primarily focuses upon suppression of oxidative stress in tissues and food systems (Bopitiya and Madhujith 2014;Wang et al 2015). Likewise, numerous studies have shown that PoPx to exhibit ameliorative effects against oxidative stress, injuries in pancreatic islets, liver, skeletal muscles, colon mucosa tissues, cerebral ischemia induced brain injuries and platelet aggregation (Ahmed et al 2014;Rodriguez et al 2014;Waly et al 2014;Zargar and Pourahmad et al 2014;Wang et al 2015).…”

“…Advanced research on PoP and its extracts primarily focuses upon suppression of oxidative stress in tissues and food systems (Bopitiya and Madhujith 2014;Wang et al 2015). Likewise, numerous studies have shown that PoPx to exhibit ameliorative effects against oxidative stress, injuries in pancreatic islets, liver, skeletal muscles, colon mucosa tissues, cerebral ischemia induced brain injuries and platelet aggregation (Ahmed et al 2014;Rodriguez et al 2014;Waly et al 2014;Zargar and Pourahmad et al 2014;Wang et al 2015). Increasing trends in ethnopharmacological application of PoPx are also attributed to their minimal cytotoxic effects at relatively higher doses, that is 5000 mg/kg body weight (Reddy et al 2014).…”

Gamma Amino Butyric Acid Ameliorates Jejunal Oxidative Damage in Diabetic Rats

“…5 Oxidative stress due to autooxidation of glucose and decreased antioxidant defense is believed to play a role in the onset of DM and its complications. 6 The small intestine is unique in its variety of cell types including enterocytes (small intestinal epithelial cells), goblet cells (for mucus secre tion), enteroendocrine cells (for hormone secretion) and Paneth cells which are stem cells differentiate to form enterocytes. 7 Paneth cells located at the baseof the Lieberkühn glands 8 and they synthesize substances with antimicrobial properties such as α-defensins, lysozyme and phospholipase A 2 in response to different stimuli.…”