Extended spectrum beta-lactamase production and antibiotic resistance of Escherichia coli and Klebsiella spp. isolated from hospitalized patients: data of 2011-2015

Abstract

coli and Klebsiella spp. species which are isolated from hospitalized patients of our hospital for four and a half years period.

Evaluation of Antimicrobial Resistance Rates in Klebsiella Isolates

“…Parlak et al [13] determined ciprofloxacin resistance rates of 11%, 8%, 13%, 35%, and 36% in ESBL-positive K. pneumoniae isolates between 2006 and 2010. In another study, the average ciprofloxacin resistance in the years 2011-2015 was 46% (no data for 2011; 48%, 24%, 52%, and 58% respectively for the remaining years) [19] . In another study by Nepal et al [21] , ciprofloxacin resistance of ESBL-positive K. pneumoniae isolates was 46.2%.…”

“…However, carbapenem resistance was detected at a rate of 1.3% in the other three centers [15] . More recently, a study by Saygılı Pekintürk and Akgüneş [19] reported imipenem resistance rates of 2%, 7%, 0%, 38%, and 50% respectively in the years 2011-2015. Although numerous previous studies demonstrated carbapenem susceptibility of ESBL-positive Klebsiella isolates, current evidence shows that carbapenem resistance is becoming more prevalent among ESBL-positive Klebsiella isolates.…”

In Vitro Evaluation of the Increase in MIC Value of Colistin in the Carbapenem Resistant Klebsiella pneumoniae Strains Over the Years

“…Saygılı Pekintürk ve ark. 'nın (24) yaptıkları çalışmadaki izolatların 10 (%67)'u idrar, dördü (%27) endotrakeal aspirat, biri (%6) ise kan kültüründen; %73'ü yoğun bakımlardan izole edilmiştir. Bizim çalışmamızda ise, izolatlar sırasıyla en çok kan kültürü (%38) sonra idrar (%36), trakeal aspirat (%19) izole edilmişken, en az damar içi kateterden (%7) izole edilmiştir.…”

“…Saygılı Pekintürk ve ark. (24) üreten K. pneumoniae izolatlarında kolistin direncinin 2010-2013 yılları arasında %11'den %27'ye yükseldiği belirtilmiştir (25) . 2008 yılında ABD'de yapılan çalışmada, 60 karbapenem dirençli K. pneumoniae izolatından yalnızca beşinde kolistin direncine rastlanılmıştır (26) .…”