Expression of Ezrin, E-cadherin and CD44 and their significances in gastric carcinoma

张建新,; 毛正发,; 王旭青,; 王崇高,; 吴建农,

doi:10.11569/wcjd.v16.i7.776

Cited by 3 publications

(2 citation statements)

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“…Particularly, 6 out of 7 studies recruited patients with gastric adenocarcinoma. The rest one (Zhang [ 19 ]) included multiple histological types (Table 1 ). Detailed information about Ezrin expression in each histotype was not provided by this article, but sensitivity analysis by removing this article did not significantly influenced the pooled results ( Supplementary Materials ).…”

Section: Resultsmentioning

confidence: 99%

Association of Ezrin expression with the progression and prognosis of gastrointestinal cancer: a meta-analysis

et al. 2017

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BackgroundEzrin, a cytoskeletal protein, is involved in cell adhesion. Several studies have been performed to explore the association between Ezrin and gastrointestinal cancers, but the results are inconclusive. This meta-analysis aims to assess the prognostic value of Ezrin.Materials and Methods/FindingsPubMed and EMBASE were searched. Pooled hazard ratio (HR), odds ratio (OR) and 95% confidence intervals (CI) were utilized to evaluate the association between Ezrin expression and various clinical parameters. 2701 patients from 19 studies were included in the meta-analysis. For gastric cancer, Ezrin expression was associated with tumor grade (OR 2.32, 95% CI 1.53–3.52), TNM stage (OR 4.69, 95% CI 1.38–15.89), lymph node involvement (OR 3.96, 95% CI 1.47–10.70) and overall survival (HR 1.88, 95% CI 1.33–2.66). In colorectal cancer, Ezrin expression was associated with tumor grade (OR 3.94, 95% CI 2.10–3.78), TNM stage (OR 5.66, 95% CI 1.41–22.67), lymph node metastasis (OR 9.52, 95% CI 3.93–23.02), distant metastasis (OR 3.06, 95% CI 1.77–5.31), disease free survival (HR 2.48, 95% CI 1.44–4.28). For esophageal cancer, Ezrin expression was associated with lymph node metastasis (OR 2.07, 95% CI 1.00–4.28) and overall survival (HR 1.49, 95% CI 1.17–1.89).ConclusionsEzrin expression is significantly associated with tumor grade, TNM stage, and lymph node metastasis in gastric and colorectal cancers. For gastric cancers, Ezrin is useful in predicting distant metastasis. Survival data showed that high Ezrin expression is associated with poor prognosis in gastric, colorectal and esophageal cancers. Our findings suggest that Ezrin might be a potential biomarker in several gastrointestinal cancers.

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Section: Resultsmentioning

confidence: 99%

Association of Ezrin expression with the progression and prognosis of gastrointestinal cancer: a meta-analysis

et al. 2017

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“…We found that ACS5 overexpression could increase survivin protein (antiapoptotic protein) levels and decrease caspase-3 protein (proapoptotic protein) levels. Accumulating evidence shows that the genes E-cadherin and CD44 are involved in tumor metastasis [ 36 , 37 ]. Here we found that inhibition of ACS5 expression significantly reduced CD44 mRNA levels but increased E-cadherin mRNA levels.…”

Section: Discussionmentioning

confidence: 99%

Acyl-CoA Synthetase 5 Promotes the Growth and Invasion of Colorectal Cancer Cells

Ding

Tang

Wang

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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Background and Aims Acyl-CoA synthetase 5 (ACS5) has been reported to be associated with the development of various cancers, but the role of it in colorectal cancer (CRC) is not well understood. The present study aimed to explore the potential role of ACS5 in the development and progression of CRC. Methods ACS5 expression in CRC tissues and CRC cell lines was examined, and its clinical significance was analyzed. The role of ACS5 in cell proliferation, apoptosis, and invasion was examined in vitro. Results We found that ACS5 expression was upregulated in CRC cells and CRC tissues and that high ACS5 expression was more frequent in CRC patients with excess muscular layer and with poor tumor differentiation. Furthermore, knockdown of ACS5 in HT29 and SW480 cells significantly dampened cell proliferation, induced cell apoptosis, and reduced cell migration and invasion. In contrast, the ectopic overexpression of ACS5 in LOVO and SW620 cells remarkably promoted cell proliferation, inhibited cell apoptosis, and enhanced cell migration and invasion. Enhanced cell growth and invasion ability mediated by the gain of ACS5 expression were associated with downregulation of caspase-3 and E-cadherin and upregulation of survivin and CD44. Conclusions Our data demonstrate that ACS5 can promote the growth and invasion of CRC cells and provide a potential target for CRC gene therapy.

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ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells

et al. 2011

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Expression of Ezrin, E-cadherin and CD44 and their significances in gastric carcinoma

Cited by 3 publications

References 0 publications

Association of Ezrin expression with the progression and prognosis of gastrointestinal cancer: a meta-analysis

Association of Ezrin expression with the progression and prognosis of gastrointestinal cancer: a meta-analysis

Acyl-CoA Synthetase 5 Promotes the Growth and Invasion of Colorectal Cancer Cells

ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells

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