Association of Ezrin expression with the progression and prognosis of gastrointestinal cancer: a meta-analysis

Abstract

BackgroundEzrin, a cytoskeletal protein, is involved in cell adhesion. Several studies have been performed to explore the association between Ezrin and gastrointestinal cancers, but the results are inconclusive. This meta-analysis aims to assess the prognostic value of Ezrin.Materials and Methods/FindingsPubMed and EMBASE were searched. Pooled hazard ratio (HR), odds ratio (OR) and 95% confidence intervals (CI) were utilized to evaluate the association between Ezrin expression and various clinical parameters. 2701 patients from 19 studies were included in the meta-analysis. For gastric cancer, Ezrin expression was associated with tumor grade (OR 2.32, 95% CI 1.53–3.52), TNM stage (OR 4.69, 95% CI 1.38–15.89), lymph node involvement (OR 3.96, 95% CI 1.47–10.70) and overall survival (HR 1.88, 95% CI 1.33–2.66). In colorectal cancer, Ezrin expression was associated with tumor grade (OR 3.94, 95% CI 2.10–3.78), TNM stage (OR 5.66, 95% CI 1.41–22.67), lymph node metastasis (OR 9.52, 95% CI 3.93–23.02), distant metastasis (OR 3.06, 95% CI 1.77–5.31), disease free survival (HR 2.48, 95% CI 1.44–4.28). For esophageal cancer, Ezrin expression was associated with lymph node metastasis (OR 2.07, 95% CI 1.00–4.28) and overall survival (HR 1.49, 95% CI 1.17–1.89).ConclusionsEzrin expression is significantly associated with tumor grade, TNM stage, and lymph node metastasis in gastric and colorectal cancers. For gastric cancers, Ezrin is useful in predicting distant metastasis. Survival data showed that high Ezrin expression is associated with poor prognosis in gastric, colorectal and esophageal cancers. Our findings suggest that Ezrin might be a potential biomarker in several gastrointestinal cancers.

The clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas: a meta‐analysis

“…This was consistent with the results of a previous meta‐analysis in patients with osteosarcoma and might have been caused by the limited number of studies of nonosteosarcoma that were included. In a recent meta‐analysis , the results showed that ezrin expression was not correlated with the distant metastasis of either gastric or esophageal cancers. Ezrin was suggested to be involved in the metastasis of osteosarcoma , and the underlying molecular mechanism involved in the modulation of metastasis by ezrin might be different in different cancers.…”

Clinicopathological significance of heterogeneic ezrin expression in poorly differentiated clusters of colorectal cancers

“…High Ezrin expression levels were significantly associated with tumor progression and poor prognosis, as well as with independent predictors of lymph node metastasis . A meta‐analysis showed that Ezrin expression is significantly associated with tumor grade, TNM stage and lymph node metastasis in CRC . Intense cytoplasmic Ezrin immunoreactivity predicts poor survival in CRC .…”

“…Ezrin is a member of the Ezrin–radixin–moesin (ERM) protein family, which links the actin cytoskeleton to the plasma membrane. Several lines of evidence suggest relationships among Ezrin expression, nodal involvement and prognosis . Even though the authors detected Ezrin expression mainly in the cytoplasm in CRC specimens, Ezrin expression in PDC and MP components has not been analyzed.…”

Circulating Actin-Binding Proteins in Progression of Laryngeal and Hypoharyngeal Cancers

“…Актин-связывающие белки, кроме обеспечения локомоции, ассоциированы с другими клеточными процессами: пролиферацией, апоптозом, эндо-и экзоцитозом. Важное значение в развитии злокачественных опухолей принадлежит актинсвязывающим белкам: кофилину, профилину, эзрину, фасцину и аденилил-циклаза ассоциированному протеину 1 (САР1) [3][4][5][6][7][8][9]. Основная функция САР1 у эукариот -регуляция реконструкции актина в ответ на клеточные сигналы.…”

“…Другими актин-связывающими белками, важными для реогранизации цитоскелета, являются эзрин и фасцин. Эзрин выступает в качестве линкера между плазматической мембраной и актиновым цитоскелетом, участвует в самых разнообразных клеточных процессах, таких как клеточная адгезия, выживание, подвижность, а также сигнальная трансдукция [8]. Фасцин вовлечен в формирование пучков фибриллярного актина и участвует в образовании стабильных долгоживущих протрузий, которые способствуют нарушению эпителиальных межклеточных контактов и приводят к инвазии опухолевых клеток во внеклеточный матрикс [6].…”