Exposure to iron and welding fumes and the risk of lung cancer

Siew, Sie Sie; Kauppinen, Timo; Kyyrönen, Pentti; Heikkilä, Pirjo; Pukkala, Eero

doi:10.5271/sjweh.1296

Cited by 69 publications

(55 citation statements)

References 23 publications

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“…A study of lung cancer in Canada found an excess risk for exposure to PAHs from any occupational source among light smokers and nonsmokers only; a Dutch study reported inconsistent results 25) . Occupational exposure to welding fumes and dusts was associated with a higher relative risk of epidermoid carcinomas than that of other histological types 26) . In one study, there was excessive risk of small cell carcinoma and epidermoid carcinoma in comparison with adenocarcinoma 27) .…”

Section: Discussionmentioning

confidence: 97%

Occupational Exposure and Thoracic Malignancies, Is There a Relationship ?

Baser

Duzce

Evyapan

et al. 2013

Journal of Occupational Health

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and 300 healthy controls were enrolled in this casecontrol study. Life-long occupational history, gender, age, exposure to asbestos, comorbidities, and smoking status were collected. Results: The mean age of the 300 lung cancer cases was 60.3 ± 9.9 year (91.7% male and 8.3% female), and the mean age of healthy control group was 60.4 ± 10.5 year (95.0% male and 5.0% female). The most frequent histological types were squamous (172, 57.3%), adeno (69, 23.1%), and small cell (37, 12.3%). There was an increased risk of lung cancer occurrence among agriculture workers (OR=1.89, 95% Cl=1.17−2.98) (p=0.009). Inorganic dust exposure (OR=1.81, 95% Cl=1.0−3.25) (p=0.049) and organic dust exposure (OR=1.89, 95% Cl=1.0−3.59) (p=0.05) were found to be related with high frequency of having lung cancer. Conclusion: Workers who had occupational exposure to organic and inorganic dust, especially in the agricultural field, had higher risk of lung cancer occurrence when compared with office workers. (J Occup Health 2013; 55: 301-306)

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Section: Discussionmentioning

confidence: 97%

Occupational Exposure and Thoracic Malignancies, Is There a Relationship ?

Baser

Duzce

Evyapan

et al. 2013

Journal of Occupational Health

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“…Nickel oxides are found with the arc process (MIG, MAG, TIG), brazing or gas welding, according to the type of metal used 25. In order to disentangle the effect of such complex exposures, epidemiological studies either investigated a specific industry (eg, shipyards),20 23 26–28 or focused on the welded material (stainless steel, mild steel),16 17 20 26 27 29–35 or on the specific chemicals released by the welding (Cr VI, nickel compounds) 1 26 28 31 36 37. Our questionnaire included detailed questions on the type of metal and the welding process; however, most participants reported welding several metals with different processes, since the study was set up in the general population.…”

Section: Discussionmentioning

confidence: 99%

Welding, a risk factor of lung cancer: the ICARE study

Matrat¹,

Guida²,

Mattei³

et al. 2016

Occup Environ Med

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“…Epidemiologic studies indicate a 20–40% increased risk of lung cancer among welders (Ambroise et al 2006; Siew et al 2008). Experimental studies are suggestive—but not conclusive—of lung carcinogenicity of welding-fume exposure (Antonini 2003; Zeidler-Erdely et al 2008).…”

Section: Overarching Topicsmentioning

confidence: 99%

Research Recommendations for Selected IARC-Classified Agents

Ward

Schulte

Straif

et al. 2010

Environ Health Perspect

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ObjectivesThere are some common occupational agents and exposure circumstances for which evidence of carcinogenicity is substantial but not yet conclusive for humans. Our objectives were to identify research gaps and needs for 20 agents prioritized for review based on evidence of widespread human exposures and potential carcinogenicity in animals or humans.Data sourcesFor each chemical agent (or category of agents), a systematic review was conducted of new data published since the most recent pertinent International Agency for Research on Cancer (IARC) Monograph meeting on that agent.Data extractionReviewers were charged with identifying data gaps and general and specific approaches to address them, focusing on research that would be important in resolving classification uncertainties. An expert meeting brought reviewers together to discuss each agent and the identified data gaps and approaches.Data synthesisSeveral overarching issues were identified that pertained to multiple agents; these included the importance of recognizing that carcinogenic agents can act through multiple toxicity pathways and mechanisms, including epigenetic mechanisms, oxidative stress, and immuno- and hormonal modulation.ConclusionsStudies in occupational populations provide important opportunities to understand the mechanisms through which exogenous agents cause cancer and intervene to prevent human exposure and/or prevent or detect cancer among those already exposed. Scientific developments are likely to increase the challenges and complexities of carcinogen testing and evaluation in the future, and epidemiologic studies will be particularly critical to inform carcinogen classification and risk assessment processes.

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Exposure to iron and welding fumes and the risk of lung cancer

Cited by 69 publications

References 23 publications

Occupational Exposure and Thoracic Malignancies, Is There a Relationship ?

Occupational Exposure and Thoracic Malignancies, Is There a Relationship ?

Welding, a risk factor of lung cancer: the ICARE study

Research Recommendations for Selected IARC-Classified Agents

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