Exposure assessment of Portuguese infants to Aflatoxin M1 in breast milk and maternal social-demographical and food consumption determinants

Bogalho, Fernando; Duarte, Sofia; Cardoso, MJ; Almeida, Anabela; Cabeças, Ricardo; Lino, Celeste M.; Pena, Angelina

doi:10.1016/j.foodcont.2018.02.043

Cited by 40 publications

(38 citation statements)

References 25 publications

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“…the first study used HPLC with fluorescence detection and the later one used ELISA assay. The 60% and above incidence of AFM1 in human biological fluids was also reported for the populations of Czech Republic (Ostry et al 2005) and Serbia (Kos et al 2014) while in Portugal the AFM1 was detected in 32.8% of maternal breast samples (Bogalho et al 2018).…”

Section: Mycotoxin Biomonitoring Studies In Africasupporting

confidence: 58%

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018

Al-Jaal

Jaganjac

Barcaru

et al. 2019

Food and Chemical Toxicology

136

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Section: Mycotoxin Biomonitoring Studies In Africasupporting

confidence: 58%

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018

Al-Jaal

Jaganjac

Barcaru

et al. 2019

Food and Chemical Toxicology

136

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“…The infants EDI of AFM1 was calculated from the daily intake of starter and follow- on formula, the average AFM1 level in IFM samples, and mean body weight (b.w.) for infants (Bogalho et al ., 2018). The two daily IMF consumption estimates were considered: 150 mL/kg b. wt.…”

Section: Methodsmentioning

confidence: 99%

Contamination level and exposure assessment to Aflatoxin M1 in Jordanian infant milk formulas

Awaisheh¹,

Rahahleh²,

Al-Groom

et al. 2019

Ital J Food Safety

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Aflatoxin M1 (AFM1) is a principal hydroxylated-aflatoxin B1 (AFB1) metabolite, and has been classified as possible human carcinogen (group 2B). The aim of this study was to survey the contamination level, estimated daily intake (EDI) and tolerable daily intake % (TDI%) of AFM1 in Jordanian infant milk formulas. A total of 120 samples, 48 starter and 72 follow-on formula samples were collected and analyzed using ELISA technique. Of the 120 surveyed samples, 58 (48.33%) were AFM1-positive and exceeded the EU maximum limit for AFM1 in IMF (25 ng/kg). The average AFM1 concentration was 69.93 and 84.78 ng AFM1/kg, with range of <5 − 89.25 and <5 – 213.84 ng AFM1/kg in starter and follow-on formula, respectively. It is also noteworthy the high EDI of AFM1 by infants (1.557 and 1.551 ng AFM1/kg b.w./day), and the high TDI% values (786.9 and 775.9%). In addition, current study indicated high-extrapolated AFB1 content in the feed; accordingly, raised the need to implement good agricultural and hygienic practices as preventive and controlling measures to decrease AFM1 in milk and IMF through controlling AFB1 in feed at the farm level. Finally, it is obvious that the contamination of IMF by AFM1 is an international problem, and the protection of infants and young children against AFM1 in Jordan requires a fundamental setup of clear legal limits of AFM1 in Jordanian standards and strict monitoring and continual analysis of IMF traded and consumed in Jordan.

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“…A total of 67 breast milk was sampled and examined results found that 32 out of 67 samples contained AFM1 constituting (32.8%). The level of AFM1 found exceeded the limit of the EU standard ranging from 5.1 and 10.6 ng/L (7.4 ± 1.9 ng/L)[41]. The higher levels of AFM1 found in matured breast milk require both food safety measures as well as public health attention.…”

mentioning

confidence: 79%

<i>Aflatoxin</i> M1 (<i>Aspergillus parasiticus, flavus</i>) Occurrences in Milk and Milk Products and Its Possible Health Effects

Bukari¹,

Kwofie²,

Adeboye³

2020

AiM

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Aflatoxin M1 (AFM1) occurrence in milk and milk products has been a major concern among food scientists over the past three decades owing to its possible health risk in humans. The well-documented AFM1 associated adverse health outcomes include hepatocarcinogens, mutagens genotoxins, mutagenicity, and teratogen. The paper reviews the occurrence of AFM1 in milk, milk products, and human milk in developing and developed countries, with its safety standards of regulation. The health associated risks with AFM1 are the important methods used in detecting and reducing AFM1 in milk and other milk products are presented.

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Exposure assessment of Portuguese infants to Aflatoxin M1 in breast milk and maternal social-demographical and food consumption determinants

Cited by 40 publications

References 25 publications

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018

Contamination level and exposure assessment to Aflatoxin M1 in Jordanian infant milk formulas

<i>Aflatoxin</i> M1 (<i>Aspergillus parasiticus, flavus</i>) Occurrences in Milk and Milk Products and Its Possible Health Effects

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Exposure assessment of Portuguese infants to Aflatoxin M1 in breast milk and maternal social-demographical and food consumption determinants

Cited by 40 publications

References 25 publications

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018

Contamination level and exposure assessment to Aflatoxin M1 in Jordanian infant milk formulas

&lt;i&gt;Aflatoxin&lt;/i&gt; M1 (&lt;i&gt;Aspergillus parasiticus, flavus&lt;/i&gt;) Occurrences in Milk and Milk Products and Its Possible Health Effects

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<i>Aflatoxin</i> M1 (<i>Aspergillus parasiticus, flavus</i>) Occurrences in Milk and Milk Products and Its Possible Health Effects