Exploration of Healing Promoting Potentials of Roots of Ficus religiosa

Murti, Krishna; Lambole, Vijay; Gajera, Vipul; Panchal, Mayank

doi:10.5567/pharmacologia.2011.374.378

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…Both 5 and 10% ointments of Ficus religiosa root extracts promoted the wound-healing activity significantly in all the wound models studied. They increased the rate of wound contraction, decreased the period for epithelialisation, increased skin breaking strength and increased hydroxyproline content [115]. The wound healing activity of Ficus religiosa hydroalcoholic leaf extracts ointment (5 and 10%) was studied in rats using excision and incision wound models.…”

Section: Wound Healing Effectmentioning

confidence: 99%

Pharmacology of Ficus religiosa- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Chemical analysis showed that Ficus religiosa contained tannins, phenols, saponins, sugars, alkaloids, methionine, terpenoids, flavonoids, glycosides, proteins, separated amino acids, essential and volatile oils and steroids. Previous pharmacological studies revealed that Ficus religiosa possessed antimicrobial, anti-parasitic, anti-Parkinson's, anticonvulsant, anti-amnesic, anticholinergic, antidiabetic, antiinflammatory, analgesic, cytotoxic, anti-ulcer, wound healing, antioxidant, anti-asthmatic, reproductive, hepato-, nephro-and dermato-protective effects. The current review highlights the chemical constituents and pharmacological effects of Ficus religiosa.

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Section: Wound Healing Effectmentioning

confidence: 99%

Pharmacology of Ficus religiosa- A review

Al-Snafi¹

2017

IOSRPHR

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“…Tridex procumbens, Trigonella foenumgraecum, Leucas lavandulaefolia and Aloe vera have shown promising wound healing activity [8] .…”

Section: Introductionmentioning

confidence: 99%

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Murti

Kumar²

2012

Asian Pacific Journal of Tropical Biomedicine

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“…Collagen provides integrity and strength to the tissue matrix and plays a vital role in epithelization and homeostasis. 44 Studies have revealed a lower quantity of hydroxyproline in diabetic patients with foot ulcers that delay the repair process. They further suggested that the usage of approved available drugs and applications would increase the tissue hydroxyproline content.…”

Section: Hydroxyproline Estimationmentioning

confidence: 99%

A Biochemical and Molecular Insight to Wound Healing Properties of Traditional Indian Medicines in Normal and Diabetic Rats

Prabhath,

Bhat,

Pai

et al. 2024

Ind. J. Pharm. Edu. Res

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Background: Honey, ghee, Glycyrrhiza glabra L. (GG), and Nerium indicum Mill. (NI) have been effectively used in Ayurveda and Indian folk medicine for healing both normal and diabetic wounds. However, the exact biochemical and molecular mechanisms involved are less discussed. The present study explores the wound healing efficacy of these traditional medicines in normal and diabetic rats using biochemical and molecular parameters. Materials and Methods: Normal and Streptozotocin-induced diabetic Wistar rats were used for the study and inflicted with excision wounds. The test materials, i.e., honey, ghee, GG, and NI, were topically applied to the wounds singly and in combinations (H+G: Honey+Ghee and Tot-combination of all test materials). On the 8 th and 16 th days of healing, biochemical and molecular parameters were assessed using the tissues procured from the wound site. We quantified the levels of hydroxyproline and antioxidants (CAT-Catalase, GSH-Glutathione, SOD-Superoxide dismutase, MDA-Malondialdehyde). We also measured the mRNA expression of growth factors, i.e., Transforming Growth Factor-beta (TGFβ), fibroblast growth factor 2 (FGF2), Platelet-Derived Growth Factor (PDGF), and vascular endothelial growth factor (VEGF). Results: Biochemical analysis showed enhanced hydroxyproline levels in both normal and diabetic wounds treated with the test materials. The groups treated with GG in normal and NI and Tot in diabetic wounds showed statistically significant findings (p<0.05). Different study materials showed significant antioxidant properties at different intervals of wound healing. Similarly, different test materials enhanced the expression of different growth factors at the wound site. Conclusion: Result indicates that the wound healing properties of these natural traditional medicines are through their antioxidant and growth factor enhancing capability at the wound site.

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Exploration of Healing Promoting Potentials of Roots of Ficus religiosa

Cited by 9 publications

References 6 publications

Pharmacology of Ficus religiosa- A review

Pharmacology of Ficus religiosa- A review

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

A Biochemical and Molecular Insight to Wound Healing Properties of Traditional Indian Medicines in Normal and Diabetic Rats

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