Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Murti, Krishna; Kumar, Upendra

doi:10.1016/s2221-1691(12)60022-7

Cited by 44 publications

(23 citation statements)

References 14 publications

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“…Mainly bark is used for skin diseases, ulcers, diabetes, piles, dysentery, asthma, gonorrhea, leucorrhea and urinary disease. The methanol extract of bark also presented an anti-diabetic effect in Streptozotocin and alloxaninduced diabetic rats [19], [23]-[27]. F. religiosa is mainly found in the sub-himalayan tract, Bengal and central India.…”

Section: Resultsmentioning

confidence: 99%

Molecular docking analysis of candidate compounds derived from medicinal plants with type 2 diabetes mellitus targets

Singh

2019

Bioinformation

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Herbal drugs are used for the treatment of diseases and disorders with its less side effects, easy availability and low cost. Several bioactive compounds have been isolated from medicinal plants such as Ficus benghelensis, Ficus racemosa, Ficus religiosa, Thespesia populena and Ficus lacur bouch were taken for screening. This study aimed to evaluate molecular interactions of selected diabetes mellitus (DM) targets with bioactive compounds isolated from Ficus benghelensis, Ficus racemosa, Ficus religiosa, Thespesia populena and Ficus lacur bouch. In this article, screening of the best substances as bioactive compounds is achieved by molecular docking analysis with 3 best selected DM target proteins i.e., aldose reductase (AR), Insulin Receptor (IR) and Mono-ADP ribosyltransferase-sirtuin-6 (SIRT6). In this analysis six potential bioactive compounds (gossypetin, herbacetin, kaempferol, leucoperalgonidin, leucodelphinidin and sorbifolin) were successfully identified on the basis of binding energy (>8.0 kcal/mol) and dissociation constant using YASARA. Out of six compounds, herbacetin and sorbifolin were observed as most suitable ligands for management of diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

Molecular docking analysis of candidate compounds derived from medicinal plants with type 2 diabetes mellitus targets

Singh

2019

Bioinformation

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“…The 10% (w/w) extract ointment treated group revealed faster wound area contraction from day 6 to day 14, whereas the 5% (w/w) extract ointment treated group showed statistically significant wound area contraction starting from the 8th day onwards. The higher wound contraction rate of the extract ointment may be due to either its dose-dependent antibacterial effect or induction of macrophage cell proliferation [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae)

Demilew

Adinew

Asrade

2018

Evidence-Based Complementary and Alternative Medicine

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Background Medicinal plants play indispensable roles to treat various ailments. Acanthus polystachyus is one of the medicinal plants used traditionally for treatment of wounds. However, there were no scientific reports documented so far on the wound healing activities of this plant. Thus, the present study provides a scientific evaluation for the wound healing potential of the crude extract of A. polystachyus leaves. Methods The crude extraction was carried out using 80% methanol. The crude extract was prepared in 5% (w/w) and 10% (w/w) ointment and evaluated for wound healing activity using excision, infected, and incision wound models in Swiss albino mice. Results Both 5% and 10% (w/w) ointments significantly reduced period of epithelialization and increased wound contraction rate and tensile strength compared to the negative control group (P < 0.05). The wound healing activity of 10% (w/w) ointment treated group was greater than 5% (w/w) and nitrofurazone ointment treated groups in S. aureus infected wound model. Conclusion These results demonstrate that the crude extract of A. polystachyus leaves possesses wound healing activities. This justifies the traditional claimed use of the plant for treating uninfected and infected wounds caused by S. aureus.

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“…The major goal in skin wound healing is the restoration of functional connective tissue and rapid wounds closure, as soon as possible, with minimal pain, discomfort and scarring. [24][25][26][27] It is expected that a therapeutic agent for the treatment of skin wounds is able to improve one or more wound healing phases with no deleterious side effects. [28] For this purpose, various types of dressings and topical products are used.…”

Section: Discussionmentioning

confidence: 99%