Experimental Human Gingivitis

Friedman, Lawrence; Klinkhamer, James M.

doi:10.1902/jop.1971.42.11.702

Cited by 22 publications

(7 citation statements)

References 8 publications

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“…In clinical use it will be important to make the OMR estimations at the same time of the day. The mean OMR values for adults obtained (0.266 X lm ± 0.115) correspond to the healthy control values of Skovgaard et al (1969), Friedman & Klinkhamer (1971), Woolweaver et al (1972), though their values are somewhat higher and the range of the OMR wider. The proper selection of healthy subjects used here might be the reason for this.…”

Section: Discussionsupporting

confidence: 79%

“…This was designated the orogranalocyte migratory rate -OMR; this abbreviation will be used in this paper. A correlation between the OMR and the degree of periodontal disease has been shown (Skougaard, Bay & Klinkhamer 1969, Klinkhamer & Zimmerman 1969, Friedman & Klinkhamer 1971, Woolweaver et al 1972, and the estimation of oral leukocyte counts has been suggested for use as a non-subjective laboratory test measuring oral health. In a study of experimental gingivitis in man, Schiott & Loe (1970) were unable to confirm the validity of this test; furthermore they found that oral leukocyte counts vary fro'm person to person.…”

Section: Introductionmentioning

confidence: 99%

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Leukocyte migration into the healthy dentuious mouth A study in children, adolescents and adults

Raeste

Tapanila

Tupakka

1977

J of Periodontal Research

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The leukocyte migratory rate (OMR) was estimated with serial mouth rinses, in healthy children, adolesceats and adults with tbe following results (S + s.d.): 0.305 ± 0.094. 0.221 ± 0.102, 0.266 ± 0.115. The number of teeth and the number of erupting teeth did not influence the OMR. The OMR values obtained were uniform with small individual variations, representing healthy conditions in the moutb.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Leukocyte migration into the healthy dentuious mouth A study in children, adolescents and adults

Raeste

Tapanila

Tupakka

1977

J of Periodontal Research

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“…The OMR was found to be correlated with gingival index (Klinkhammer & Zimmerman 1969). In an experimental gingivitis model, the number of granulocytes in saliva increased before the appearance of clinical gingivitis (Friedman & Klinkhammer 1971, Skougaard et al 1969.…”

Section: Inflammatory Cellsmentioning

confidence: 90%

Analysis of saliva for periodontal diagnosis

Kaufman

Lamster

2000

J Clinic Periodontology

335

293

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A number of markers show promise as sensitive measures of disease and the effectiveness of therapy. At this time, host-derived enzymes and other inflammatory mediators orginating from the gingival crevice appear to hold the greatest promise as salivary diagnostic tests for periodontal disease. Longer-term longitudinal studies, however, are required to establish the relationship between specific markers and progression of periodontal disease. Furthermore, analysis of saliva may offer a cost-effective approach to assessment of periodontal disease in large populations.

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“…No correlation exists leukocytes entering the oral cavity in 30 s, between leukocyte counts in saliva and in a measure which he designated as the peripheral blood either in health or in orogranulocytic migratory rate (OMR). disease (COMROE 1934, STEPHENS & JONES Many workers have documented a 1934, WOOLWEAVER, KOCH, CRAWFORD & relationship between OMR and in-LiNDBLAD 1972), but leukocyte counts in creasingly severe clinical gingivitis saliva do reflect conditions in the oral (KLINKHAMER 1968, SKOUGAARD, BAY & KLINKHAMER 1969, FRIEDMAN & KLINKHAMER 1971). But at low and high gingival index (GI) values (LOE & SiLNESS 1963) the correlation with OMR was not significant, probably because GI is not a true parametric index corresponding to the histologic situation in the tissues.…”

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confidence: 99%

Rate of migration of oral leukocytes in patients with periodontitis

Raeste

Aura

1978

European J Oral Sciences

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The rate of migration of leukocytes (OMR) was estimated by counts of sequential mouthrinses in 81 human subjects in order to evaluate its usefulness as a laboratory test of oral inflammation. Periodontitis was taken as a model, and neither patients nor controls had any other oral inflammation. Patients with advanced periodontitis, but with periodontal destruction of about the same level, were divided into two groups, acute phase and chronic phase. The mean number of leukocytes entering the oral cavity in 30 s was estimated in these two groups. In the same patients the difference between the cell count in the first rinse and the OMR level was estimated, to test whether it could be taken to indicate the grade of acuteness of the inflammadon (GAD. OMR and GAI were assessed in the patients with periodontitis after the initial treatment and at loUow-up 1 year after completion of the full treatment, which almost always included surgical procedures. The results indicate that the OMR reflects the existence of oral in-(lammation and can be used as a laboratory test with the same resen'ations as white blood cell counts for systemic inflammation. The difference in GAI between patients in the acute and chronic phases of the disease was highly significant, indicating that this test gives information about the severity of the inflammation.

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Experimental Human Gingivitis

Cited by 22 publications

References 8 publications

Leukocyte migration into the healthy dentuious mouth A study in children, adolescents and adults

Leukocyte migration into the healthy dentuious mouth A study in children, adolescents and adults

Analysis of saliva for periodontal diagnosis

Rate of migration of oral leukocytes in patients with periodontitis

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