Experimental glomerulonephritis in the isolated perfused rat kidney.

Abstract

A B S T R A C T The development of immune deposits on the subepithelial surface of the glomerular capillary wall was studied in isolated rat kidneys perfused at controlled perfusion pressure, pH, temperature, and flow rates with recirculating oxygenated perfusate containing bovine serum albumin (BSA)

Hematopoietic Stem Cells Contribute to the Regeneration of Renal Tubules after Renal Ischemia-Reperfusion Injury in Mice

“…Kidney sections were serially stained with an antibody to ␤-galactosidase followed by antibodies or lectins to various renal cell markers (23)(24)(25)(26)(27). Kidney frozen sections (10-m-thick) were fixed with ice-cold 1:1 methanol:acetone for 10 min.…”

Antigen size influences the type of glomerular pathology in chronic serum sickness

“…Not long afterward, Germuth [3] demonstrated an additional role for circulating immune complexes in experimental serum sickness glomerulonephritis, in this case leading to a granular binding of IgG along the GCW. New studies began to show that a pathogenic role played by antibodies directed against glomerular intrinsic or planted antigens can induce either linear or granular binding of IgG along the GCW [4][5][6]. Models have recently been described in which the binding pattern of antibodies to the glomerulus can change from linear to granular in the course of the disease.…”

Evolution in the Understanding of Idiopathic Membranous Nephropathy Pathogenesis: From Experimental Models to the Clinic

“…Van Damme [7] и W.G. Couser [8] обнаружили, что найденный антиген экспресси-руется также и в подоцитах. Это послужило объ-яснением повреждения клубочков и позволило обсуждать образование субэпителиальных им-мунных комплексов in situ.…”