2015
DOI: 10.2174/1874440001509010007
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Experimental Fusion of Contrast Enhanced High-Field Magnetic Resonance Imaging and High-Resolution Micro-Computed Tomography in Imaging the Mouse Inner Ear

Abstract: Objective: Imaging cochlear, vestibular, and 8th cranial nerve abnormalities remains a challenge. In this study, the membranous and osseous labyrinths of the wild type mouse inner ear were examined using volumetric data from ultra high-field magnetic resonance imaging (MRI) with gadolinium contrast at 9.4 Tesla and high-resolution micro-computed tomography (µCT) to visualize the scalae and vestibular apparatus, and to establish imaging protocols and parameters for comparative analysis of the normal and mutant … Show more

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Cited by 10 publications
(3 citation statements)
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References 23 publications
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“…Details up to a sub-cellular level can be visualized by high-resolution tomography of a part of an osmium stained inner ear (Lareida et al, 2009 ). Except for staining, histology or different imaging techniques, such as MRI (Counter et al, 2015 ) or transmission electron microscopy (Handschuh et al, 2013 ), can be combined with micro-CT images to obtain more detailed volumes. This combination could result in better visibility of, for example, the endolymphatic ducts.…”
Section: Discussionmentioning
confidence: 99%
“…Details up to a sub-cellular level can be visualized by high-resolution tomography of a part of an osmium stained inner ear (Lareida et al, 2009 ). Except for staining, histology or different imaging techniques, such as MRI (Counter et al, 2015 ) or transmission electron microscopy (Handschuh et al, 2013 ), can be combined with micro-CT images to obtain more detailed volumes. This combination could result in better visibility of, for example, the endolymphatic ducts.…”
Section: Discussionmentioning
confidence: 99%
“…The incidence of rectal cancer is one of the most malignant tumors in the world [ 1 3 ]. Accurate clinical staging is the key to treatment decision, especially for rectal cancer [ 2 , 3 ]. In the past century, medical imaging technology has experienced various hardships and achieved many new achievements in its continuous development [ 3 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…Thus, intravital MPM eliminates the need for invasive tissue sampling and complex preparation, while enabling the volumetric visualization of a specimen. Various methods, such as laser-Doppler flowmetry ( 11 , 12 ), micro-computed tomography (CT) ( 13 , 14 ), and magnetic resonance imaging ( 15 ), have been applied to visualize the microstructures over the cochlear bone. However, these techniques reveal only the blood vessels over the cochlear bone or require the invasive use of contrast media to identify the microstructure of the SM.…”
Section: Introductionmentioning
confidence: 99%