Experimental Bronchomoniliasis in Sensitized Rabbits

Kurotchkin, T. J.; Lim, Chae-Young

doi:10.3181/00379727-31-7115c

Cited by 9 publications

(2 citation statements)

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“…The same phenomenon was observed in germfree rats vaccinated with FKCA in CFA 2 weeks before challenge. The reason for this suppression is not clear, but suppression of cellular immunity by C. albicans has been reported previously by other investigators (5,16,19). Suppression of cellular immunity by a variety of other microorganisms has also been reported (4,7,10,21,23,27).…”

Section: Discussionmentioning

confidence: 77%

Effect of Systemic Candidiasis on Blastogenesis of Lymphocytes from Germfree and Conventional Rats

Rogers

Balish

1978

Infect Immun

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Germfree and conventional rats were challenged (intravenously) with Candida albicans and sacrificed at various times after infection, and their spleen cells were harvested to examine the effect of disseminated candidiasis on in vitro lymphocyte hypersensitivity to Candida antigens (CA). Results showed that conventional rat splenocytes, initially responsive in vitro to stimulation by CA, manifested a depression in CA-specific responsiveness after challenge with viable C. albicans (days 3 to 6 postchallenge). In addition, the latter splenocyte response to phytohemagglutinin (PHA) and concanavalin A (ConA) was suppressed by 3 to 6 days after challenge with Candida. In contrast to conventional rats, the response of germfree rat splenocytes to CA was insignificant before challenge with C. albicans, and it was increased at 9 days after infection. The response of uninfected germfree rat splenocytes to PHA and ConA was significantly lower than that of unchallenged conventional rats. Challenge with viable C. albicans did not result in a suppression of gnotobiotic rat splenocyte responses to PHA and ConA, but rather, the disseminated infection resulted in as much as fivefold increases in PHA or ConA-induced blastogenesis. These findings suggest that disseminated candidiasis is capable of suppressing blastogenesis in immunologically mature conventional rats and of improving lymphocyte blastogenesis from immunologically immature germfree rats.

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Section: Discussionmentioning

confidence: 77%

Effect of Systemic Candidiasis on Blastogenesis of Lymphocytes from Germfree and Conventional Rats

Rogers

Balish

1978

Infect Immun

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“…THE possibility of sensitization of the individual to G: albicans has been recognized by many authors. The early literature up to 1962 has been well reviewed by Winner and Hurley (1964), who record that sensitization studies in animals were reported by Kurotchin and Lim (1930a, 1930b, 1933. Sclafer and Flavian (1954) found that in 285 children aged 1-16, cutaneous allergy to G. albicans was demonstrated in 23%, and after the first year of life the frequency of this sensitization increased with the age of the subject.…”

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confidence: 99%