Exostoses and Vascular Complications in the Lower Limbs: Two Case Reports and Review of the Literature

Nasr, Bahaa; Albert, Bénédicte; David, C; Fonseca, Pedro; Badra, Ali; Gouny, P

doi:10.1016/j.avsg.2015.02.020

Cited by 25 publications

(32 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More rarely vascular compressions are seen, especially at the lower limb. Popliteal artery is most often involved, with pseudo aneurysm formation or thrombosis, claudication ( Figure 4) and ischaemia (38). As case report, is described in literature an acute coronary syndrome due to dynamic extrinsic coronary artery compression by a rib exostoses (39).…”

Section: Neurovascular Disordermentioning

confidence: 99%

Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern

Beltrami

Ristori

Scoccianti

et al. 2016

ccmbm

View full text Add to dashboard Cite

SummaryHereditary multiple exostoses (HME) is an inherited genetic condition characterized by the presence of multiple exostoses (osteochondromas). MHE is a relatively rare autosomal dominant disorder, mainly caused by loss of function mutations in two genes: exostosin-1 (EXT1) and exostosin-2 (EXT2). These genes are linked to heparan sulfate (HS) synthesis, but the specific molecular mechanism leading to the disruption of the cartilage structure and the consequent exostoses formation is still not resolved. The aim of this paper is to encounter the main aspects of HME reviewing the literature, in order to improve clinical features and evolution, and the metabolic-pathogenetic mechanisms underlying. Although MHE may be asymptomatic, a wide spectrum of clinical manifestations is found in paediatric patients with this disorder. Pain is experienced by the majority of patients, even restricted motion of the joint is often encountered. Sometimes exostoses can interfere with normal development of the growth plate, giving rise to limb deformities, low stature and scoliosis. Other many neurovascular and associated disorders can lead to surgery. The most feared complication is the malignant transformation of an existing osteochondroma into a secondary peripheral chondrosarcoma, during adulthood. The therapeutic approach to HME is substantially surgical, whereas the medical one is still at an experimental level. In conclusion, HME is a complex disease where the paediatrician, the geneticist and the orthopaedic surgeon play an interchangeable role in diagnosis, research and therapy. We are waiting for new studies able to explain better the role of HS in signal transduction, because it plays a role in other bone and cartilage diseases (in particular malignant degeneration) as well as in skeletal embryology.

show abstract

Section: Neurovascular Disordermentioning

confidence: 99%

Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern

Beltrami

Ristori

Scoccianti

et al. 2016

ccmbm

View full text Add to dashboard Cite

show abstract

“…The tumor is presented as a locally benign neoplasm, which favors the meta-epiphyseal region of long bones like the distal femur, as well as the proximal tibia or humerus in the extremity [5] , [6] , [8] . Of all benign bone tumors, OC accounts for more than one-third, the most common benign bone tumor around the world [4] , [7] , [8] , [9] , [10] , [11] , [15] . Although it is benign, its biological behavior still has a malignant potential.…”

Section: Introductionmentioning

confidence: 99%

Osteochondroma: Review of 431 patients from one medical institution in South China

Tong

Liu

Wang

et al. 2017

Journal of Bone Oncology

View full text Add to dashboard Cite

BackgroundThe geographic distribution of osteochondroma (OC) varies greatly around the world. There has been no recent report on OC in a large Chinese population. The aim of this study was to characterize OC by an epidemiological analysis of the clinical data from one medical institution in South China.MethodsWe searched medical electronic records from January 2001 to January 2016 in one large hospital in South China to identify patients with a definite diagnosis of OC. Their epidemiological data were collected and analyzed statistically, including gender, tumor site, age at first diagnosis and symptoms, local recurrence and malignant transformation. Differences between genders and between solitary osteochondroma (SO) and multiple osteochondroma (MO) were particularly analyzed.ResultsA total of 431 OC patients (291 males and 140 females; 329 SOs and 102 MOs) were identified. The gender ratio was 2.08 with a male predominance. OCs were mostly located around the knee (250 cases). 280 patients were in their 0s to 20s upon first diagnosis. The average age at the time of first diagnosis was 20.63 years for all, 18.47 years for males and 25.11 years for females (P=0.000). OC recurred locally in 35 patients (15 SOs and 20 MOs), with a significant difference between SO/MO (P=0.000) but not between genders (P=0.100). The average interval from the primary surgery to local or malignant recurrence was 37.41 months. Malignant transformation was found in 5 patients (4 males and 1 female), showing no gender difference (P=0.549).ConclusionsOC may have a male predominance in Chinese population. It mostly occurred at 0–20 years of age and around the knee. Upon the first diagnosis of OC, the males tended to be younger than the females, and so did the MO patients than the SO ones. In addition, MO had a higher incidence of local recurrence. Intervals from primary surgery to local recurrence or malignant transformation in MO patients were longer than in SO patients.

show abstract

“…It is also called as multiple osteochondromatosis or diaphysealaclasis. [ 6 ] Exostoses are seen in all bones except skull, mandible, and facial bones. The common sites are around knee joint and humerus.…”

Section: Discussionmentioning

confidence: 99%

Concomitant neurogenic and vascular thoracic outlet syndrome due to multiple exostoses

et al. 2018

View full text Add to dashboard Cite

Exostoses and Vascular Complications in the Lower Limbs: Two Case Reports and Review of the Literature

Cited by 25 publications

References 41 publications

Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern

Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern

Osteochondroma: Review of 431 patients from one medical institution in South China

Concomitant neurogenic and vascular thoracic outlet syndrome due to multiple exostoses

Contact Info

Product

Resources

About