Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome

Trøseid, Marius

doi:10.1016/j.ehj.2003.12.006

Cited by 160 publications

(119 citation statements)

References 44 publications

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“…We observed reduction of markers of systemic inflammation and fatigue symptoms. The results of our study agreed with several previous studies suggesting 12-weeks aerobic exercise training program promotes the modulation of systemic inflammation and fatigue symptoms of obese patients with type 2 diabetes [27][28][29][30][31][32][33][34][35][36][37][38][39] . Rosety-Rodriguez and colleagues conducted a 12-week arm cranking exercise program for spinal cord injury patients at a moderate work intensity of 50% to 65% of heart rate reserve for of 3 sessions per week .…”

Section: African Health Sciences Vol 15 Issue 4 December 2015supporting

confidence: 93%

Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

2016

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Background: Non-insulin dependent diabetic patients frequently suffer from fatigue symptoms that result from chronic systemic inflammation. Aerobic exercise was proved to modulate systemic inflammation. Objective: This study was an attempt to measure the impact of aerobic exercises on fatigue symptoms related to systemic inflammation in obese patients with type 2 diabetes. Methods: Eighty obese patients with type 2 diabetes participated in the present study, their age ranged from 40-58 years and their BMI ranged from 31-36 kg/m 2 and were assigned to two subgroups; group (A) received aerobic exercise training for 12 weeks and group (B) received no exercise training for 3 months. Measurements of fatigue symptoms and markers of systemic inflammation were assessed before and at the end of the study for all participants in both groups. Results:The mean values of inflammatory markers (IL-6 and TNF-α) and Multidimensional Fatigue Inventory (MFI) was significantly decreased in group (A), while changes were not significant in group (B). Moreover, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study. Sci. 2015;15(4):1142-8. http://dx.doi.org/10.4314/ahs.v15i4.13 Conclusion

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Section: African Health Sciences Vol 15 Issue 4 December 2015supporting

confidence: 93%

Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

2016

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“…Here, again, polymorphisms in immune genes modulate risk, implying a pathogenetic significance for immune gene products Table 4 Interventions that have an impact on the inflammatory state Inflammatory mediators whose concentrations are reduced by weight loss and/or physical exercise [190][191][192][193][194][195][196][197][198][199][200][201][202][203][204][205][206][207] CRP, TNF-α, soluble TNF-α receptor 2, IL-6, IL-18, MCP-1, PAI-1, t-PA, soluble ICAM-1, soluble VCAM-1, P-selectin Inflammatory mediators whose concentrations are reduced by glucose-lowering drugs [186,188,[208][209][210][211][212][213][214][215][216][217] Sulphonylurea: TNF-α Metformin: CRP Glitazones: CRP, SAA, TNF-α, soluble CD40 ligand, PAI-1 Insulin: CRP, IL-1, IL-6, TNF-α, soluble ICAM-1, MCP-1, PAI-1 SAA Serum amyloid A, t-PA tissue plasminogen activator, VCAM-1 vascular cell adhesion molecule-1 [171][172][173]. Where studied, the upregulation of inflammatory mediators was linked to increased oxidative stress, impaired mitochondrial function and abnormal cholesterol metabolism [174][175][176].…”

Section: Low-grade Inflammation and Healthmentioning

confidence: 99%

An immune origin of type 2 diabetes?

2005

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Subclinical, low-grade systemic inflammation has been observed in patients with type 2 diabetes and in those at increased risk of the disease. This may be more than an epiphenomenon. Alleles of genes encoding immune/ inflammatory mediators are associated with the disease, and the two major environmental factors the contribute to the risk of type 2 diabetes-diet and physical activity-have a direct impact on levels of systemic immune mediators. In animal models, targeting of immune genes enhanced or suppressed the development of obesity or diabetes. Obesity is associated with the infiltration and proinflammatory activity of macrophages in adipose tissue, and immune mediators may be important regulators of insulin resistance, mitochondrial function, ectopic lipid storage and beta cell dysfunction or death. Intervention studies targeting these pathways would help to determine the contribution of an activated innate immune system to the development of type 2 diabetes.

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“…Given that human adipose tissue is also metabolically active and able to secrete MCP-1 (13), it has recently been reported that reduction in visceral fat is directly correlated to a decrease in MCP-1 levels (14), supporting a role for VAT in the systemic inflammatory condition. At present, to our knowledge, literature about the correlation between MCP-1 and abdominal adiposity is still scarce and poor evidence has been provided about a correlation between MCP-1 secretion and the VAT entity in humans (12).…”

Section: Introductionmentioning

confidence: 99%

Monocyte chemoattractant protein 1: a possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity

et al. 2005

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Objective: Obesity can be considered a state of chronic, low-grade inflammation. Particularly, visceral adipose tissue (VAT) seems to be an active compartment in pro-inflammatory molecule secretion. Adipocytes and VAT are able to produce large amounts of monocyte chemoattractant protein 1 (MCP-1), a chemokine directly involved in ventricular remodeling. Design: In this study, the possible existence of a correlation between MCP-1, abdominal fat accumulation and echocardiographic abnormalities in uncomplicated obesity was investigated. Methods: Echocardiographic parameters, MCP-1 and C-reactive protein (CRP) levels were assessed in 27 normotensive obese women of fertile age (body mass index 43.5^4.8 kg/m 2 , mean^S.D.) and 15 normal weight women. Visceral fat (VAT) in the obese group was assessed by computed tomography. Results: Obese patients had higher MCP-1 (P , 0.0001) and CRP (P , 0.0001) levels than controls. MCP-1 levels were correlated with VAT area (r ¼ 0.57, P , 0.0001), CRP (P , 0.0001), left ventricular mass (LVM) (P , 0.02), LVM indexed for height (P , 0.03), end-diastolic posterior wall (P , 0.005), relative wall thickness (P , 0.01), early diastolic filling wave velocity (P , 0.01), isovolumetric relaxation time (P , 0.001) and deceleration time (P , 0,01). Obese patients with greater amounts of VAT (. 130 cm 2 ) presented higher MCP-1 (P , 0.0001) and CRP levels (P , 0.04) than those with a lower degree of abdominal adiposity. Conclusions: MCP-1 levels and visceral adipose tissue seem to be associated with some morphological and functional echocardiographic abnormalities and support a role for visceral fat in predisposing the subject to cardiac dysfunction, possibly through a low-grade state of inflammation.

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Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome

Abstract: The protective effect of exercise might in part be due to suppression of the inflammatory process.

Cited by 160 publications

References 44 publications

Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

An immune origin of type 2 diabetes?

Monocyte chemoattractant protein 1: a possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity

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