Excess bioavailability of zinc may cause obesity in humans

Taneja, Satish Kumar; Mahajan, Monika; Arya, Poonam

doi:10.1007/bf01922412

Cited by 24 publications

(15 citation statements)

References 9 publications

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“…Further, increased Zn concentrations in the hair and nails in Group D M (middle-aged diabetics) and Group D+ OA (diabetics with osteoarthritis) also coincide well with respect to their increased body weights (Tables 1, 3, 4; Figs. 1a and 2a) because it is already reported in ours and other previous epidemiological studies where a positive relationship between Zn concentrations in hair with obesity, diabetics, and myocardial infarction but an inverse correlation with copper concentrations in hard tissues, such as hair and nails, were observed that support the present findings [21,[62][63][64]. Increase and decrease in hair and nail Zn levels in Groups OA and RA patients were reported due to the involvement of more cytokines, as RA is a chronic inflammatory disease.…”

Section: Discussionsupporting

confidence: 93%

“…Recent data on Zn levels estimated in cereals and other food stuffs was also found to be high. The higher level of Zn in tissues of overweight and obese women than those with body mass index of 25 kg/m 2 observed in Indians, more so in Punjabis [62,63], is on account of high Zn in food [72] due to the liberal use of Zn as ZnSO 4 as a micronutrient in where in spite of hyperzincuria, the diabetic patients have not appeared to be Zn deficient [73]. This is further evident by elevated Zn concentration in serum, urine, and mononuclear cell in diabetic patients after high dose Zn supplementation, which has a greater ramification in diabetes [71].…”

Section: Discussionmentioning

confidence: 93%

“…This greater bioavailability of Zn in adults over a period of years as reflected in our previous study on Chandigarh population is significant enough to reflect the changes in body weight leading to obesity [21,28,[62][63][64][65][66][67][68].…”

Section: Introductionmentioning

confidence: 97%

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Assessment of Minerals in Obesity-related Diseases in the Chandigarh (India) Population

Taneja

Mandal

2007

Biol Trace Elem Res

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Excessive Zn but normal Cu and Mg in the staple food consumed by the people of Chandigarh (Union territory and capital of Punjab and Haryana States of India) has been considered to be the major risk factor for the prevalence of obesity (33.15%) and obesity-related diseases in this region. Therefore, in the present investigations, in obesity-related diseases, the status of these minerals was estimated in their tissues, including hair, nails, and blood serum and urine, and compared with those of normal subjects. They were grouped as: normal subjects in control Group A, middle-aged diabetics in Group D(M), older diabetics in Group D(O), and diabetics with osteoarthritis in Group D+ OA, osteoarthritis in Group OA and rheumatoid arthritis in Group RA, respectively. The results evaluated in the order as: hair Zn, group D+OA>D(M)>OA>A (control)>RA>D(O) (p < 0.001); hair Cu, group A (control)>D(M)>OA>D+OA>D(O)>RA (p < 0.001); hair Mg, group A (control)>D(M)>OA>D+OA>RA>D(O) (p < 0.001, 0.01); hair Mn, group A (control)>RA>OA>D-OA>D(M)>D(O) (p < 0.001); nail Zn, group D(M)>D+OA>OA>A (control)>RA>D(O) (p < 0.001, 0.05); nail Cu, group A (control)>OA>D(M)>D+OA>RA>D(O) (p < 0.001); nail Mg, group A (control)>OA>D(M)>D(O)>D+OA >RA (p < 0.001); nail Mn, group A (control) >RA>OA>D+OA>D(M)>D(O) (p < 0.01); urine Zn, group D(O)>D(M)>D+OA>A (control)>RA>OA (p < 0.01); urine Cu, group RA>D+OA>D(O)>OA> D(M)>A (control) (p<0.001); urine Mg, group RA>OA>D+OA>D(O)>D(M)>A (control; p < 0.001); urine Mn, group D(O)>D(M)>OA>D+OA>RA>A (control; p < 0.001), respectively. The analysis of the mineral status in serum of diabetics further showed their highly significant rise from lower mean age subgroup to higher mean age subgroup than their control counter parts (p < 0.001, 0.01, and 0.05) with coincident deficiencies of Cu, Mg, and Mn in their tissues. This study would be helpful considering the status of minerals in these obesity-related diseases depending on the choice of the food consumed to improve the quality of life and prognosis for the diseases.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 93%

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Assessment of Minerals in Obesity-related Diseases in the Chandigarh (India) Population

Taneja

Mandal

2007

Biol Trace Elem Res

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“…A second factor is the sedentary lifestyle resulted in higher body mass index that was associated with its higher prevalence in the Chandigarh population [73] because total body fat had increased in the Chandigarh population as more than 73.70% population is engaged in light physical activity [72]. This increase in body weights in the Chandigarh population has also been reported to link with excessive dietary Zn, as its increase in diet than the recommended dietary allowance was evaluated to increase the body fat in rats, and higher Zn levels were observed in nail, hairs, and urine in obese than in normal subjects in the Chandigarh population according to previous studies [64,74,75].…”

Section: Discussionmentioning

confidence: 69%

Mineral Factors Controlling Essential Hypertension—a Study in the Chandigarh, India Population

Taneja

Mandal

2007

Biol Trace Elem Res

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Essential hypertension (EH) is a major public health problem world over and in India. Recent data on EH in the population of Chandigarh (Union Territory and capital of Punjab and Haryana States of India) revealed that the prevalence of EH has become double in the last 30 years in the residents of Chandigarh (26.9 to 45.80% in the year 1968 and 2002). Zinc (Zn), copper (Cu), magnesium (Mg), and manganese (Mn) in the serum are considered important in maintaining the human hypertension. The high Zn intake was considered to increase the blood pressure (BP) and to affect the other mineral status in the body. Recent survey on the trace metal status of different vegetables in the State of Punjab around Chandigarh (India) revealed that Zn level is significantly higher (40 mg/kg or more in above ground vegetables and 120 mg/kg or above in underground vegetables) in underground water-irrigated vegetables, but the levels of Cu and Mg are within prescribed limit. The present study was conducted on Chandigarh population to evaluate the levels of Zn, Cu, Mg, and Mn in the blood and urine of normotensive (NT) control and hypertensive (HT) subjects matched with number, age and sex. Atomic absorption spectrophotometer studies reevaluated that the levels of serum Zn, Mg, and Mn were significantly higher (p < 0.001), but the level of Cu was low in the HT subjects (BP = 160/93) compared to NT control (BP = 140/83). Higher levels of urinary Zn, Cu, Mg, and Mn were observed in the HT subject vs NT control (p < 0.001). Positive correlations were evaluated between the levels of serum Zn, Mg, and Mn vs systolic and diastolic pressures (DP and SP), respectively (r = 0.928, 0.863, 0.876, 0.808, 0.404, 0.326, p < 0.01), but negative and positive nonsignificant correlations between the serum Cu with SP and DP were recorded (r = -0.032, r = 0.024). Positive correlations were also evaluated between urinary levels of Zn, Cu, Mg, and Mn vs SP and DP (r = 0.718, 0.657, 0.750, 0.681, 0.630, 0.578, 0.516, 0.461, p < 0.01). Prevalence of essential hypertension may be due to higher Zn level in the food chain that makes the individuals vulnerable to other diseases over the time related to essential hypertension.

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“…5 Trace element status in obesity Consistent with some previous reports, we found lower serum zinc concentrations 16,43--45 and higher serum copper 16,46,47 and caeruloplasmin concentrations 16,48 in obese compared with non-obese subjects. However, Gjorup et al 49 reported no signi¢cant di¡erences of serum zinc concentrations between obese and non-obese subjects, and Yakinci et al 47 and Taneja et al 50 found that serum zinc concentrations in obese children were signi¢cantly higher than the control group.…”

Section: Effects Of Smoking On Trace Element Statusmentioning

confidence: 98%