Determinants of serum copper, zinc and selenium in healthy subjects

Ghayour‐Mobarhan, Majid; Taylor, Andrew; New, Susan A.; Lamb, DJ; Ferns, Gordon A.

doi:10.1258/0004563054889990

Cited by 171 publications

(112 citation statements)

References 35 publications

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“…Previously, some investigations have linked serum selenium concentrations with inflammatory biomarkers such as CRP, suggesting circulating CRP as a negative predictor of serum selenium (Ghayour-Mobarhan et al, 2005). On the other hand, vitamin and mineral supplementation is associated with lower concentrations of CRP in women, specially with selenium and vitamin E supplementation (Scheurig et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

et al. 2008

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Objectives: To evaluate the associations between serum complement factor 3 (C3) and several anthropometrical, biochemical and lifestyle features in healthy young adults, emphasizing on the putative effect of selenium intake on C3 concentrations. Methods: This study enrolled 100 healthy young adults aged 18-34 years. Anthropometric and blood pressure measurements and lifestyle features were analyzed. Fasting blood samples were collected for the measurement of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerols and C3 concentrations. Nail samples were collected for the analysis of selenium concentrations. Results: Values of BMI (P ¼ 0.034), sum of skinfold thicknesses (STs) (P ¼ 0.021), body fat mass (BFM) (P ¼ 0.023), percentage of overweight subjects (P ¼ 0.007), serum triacylglycerols (P ¼ 0.012) and nail selenium (P ¼ 0.001) were significantly different between subjects above and below the median of serum C3 concentrations. The following correlations with serum C3 were identified tricipital ST (P ¼ 0.033), sum of STs (P ¼ 0.012), BMI (P ¼ 0.008), BFM (P ¼ 0.018), waist-to-height ratio (P ¼ 0.016), serum glucose (P ¼ 0.045), serum triacylglycerols (P ¼ 0.001) and nail selenium (P ¼ 0.006). Circulating C3 showed a positive association with several adiposity markers such as BMI (P ¼ 0.001), waist circumference (P ¼ 0.006), waist-to-height ratio (P ¼ 0.002), BFM (P ¼ 0.025), as well as serum glucose (P ¼ 0.027) and triacylglycerols (Po0.001), whereas nail selenium was a statistically significant negative predictor of C3 concentrations (P ¼ 0.018). Conclusions: C3 seems to be related with selenium status and several anthropometrical and biochemical measurements linked to metabolic syndrome in apparently healthy young adults. These findings suggest a possible role for selenium intake in the modulation of C3, whose assessment may be an early marker of metabolic syndrome manifestations.

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Section: Discussionmentioning

confidence: 99%

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

et al. 2008

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“…In serum, it has been documented for Cu by Ghayour-Mobarhan et al (2005) and Kouremenou-Dona et al (2006); for Se by Lopes et al (2004). In brain, Markesbery et al (1984), Ongkana et al (2010) and Tohno et al (2010)  data converted from nmol/L Table 6.…”

Section: Agementioning

confidence: 99%

“…For changes of Se, Cu and Zn in serum, see Lopes et al (2004) and Ghayour-Mobarhan et al (2005). For Zn variations in brain, see Ongkana et al (2010).…”

Section: Gendermentioning

confidence: 99%

Minor and Trace Elements in Cerebrospinal Fluid of Parkinson's Patients – Suggestions After a Critical Review of the Analytical Data

Speziali¹,

Casa²

2011

Diagnostics and Rehabilitation of Parkinson's Disease

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“…A study of hyperlipidemic Portuguese women reported that plasma Se was positively correlated with the HDL cholesterolto-total cholesterol ratio (64). Serum Se was positively correlated with serum total cholesterol in a study of healthy men and women in the United Kingdom (29) and in Korean women under the age of 40 yr (38). Two studies in Europe reported significant positive associations of serum Se with serum polyunsaturated fat (10,44).…”

Section: Discussionmentioning

confidence: 94%

Selenium supplementation does not improve vascular responsiveness in healthy North American men

Hawkes

Laslett

2009

American Journal of Physiology-Heart and Circulatory Physiology

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Determinants of serum copper, zinc and selenium in healthy subjects

Abstract: Background We have investigated the association between serum copper, zinc and selenium concentrations, dietary intake, and demographic characteristics, including individual coronary risk factors, in healthy subjects.

Cited by 171 publications

References 35 publications

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

Minor and Trace Elements in Cerebrospinal Fluid of Parkinson's Patients – Suggestions After a Critical Review of the Analytical Data

Selenium supplementation does not improve vascular responsiveness in healthy North American men

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