Selenium supplementation does not improve vascular responsiveness in healthy North American men

Abstract

Hawkes WC, Laslett LJ. Selenium supplementation does not improve vascular responsiveness in healthy North American men.

Selenium in Human Health and Disease

“…Supplements of 200 mg=day in individuals free of CVD at baseline were not significantly associated with any CVD endpoints during 7.6 years follow-up of the entire blinded phase of the Nutritional Prevention of Cancer Trial (1983)(1984)(1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996) (350), and a randomized, placebo-controlled trial in healthy men given 300 mg=day of selenium as high-selenium yeast for 48 weeks suggested that selenium supplements were not likely to improve endothelial function or peripheral arterial responsiveness in healthy North American men receiving adequate selenium from their diets (155). Moreover, increased consumption of wheat biofortified with selenium does not modify biomarkers of cancer risk, oxidative stress, or immune function in healthy Australian males (412).…”

Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds

“…An ongoing discussion questioning usefulness and safety of dietary Se supplements has arisen: participants of two recent intervention trials did not benefit from Se supplementation, either in terms of improved cardiovascular function or in terms of tumor prevention [9,10]. It is noteworthy that the participants had high baseline plasma Se levels, pointing to already saturated expression/activity of selenoproteins at the beginning of the studies.…”

Effects of Dietary Supplementation with Brazil Nuts on Microvascular Endothelial Function in Hypertensive and Dyslipidemic Patients: A Randomized Crossover Placebo‐Controlled Trial

“…The effect of Se on microvascular function was previously investigated in healthy men who received 300 μ g Se/day for 48 weeks. No improvement was observed in endothelial function or the peripheral arterial response in the study group, and these subjects received adequate Se in their habitual diets . Only one clinical study investigated microvascular function by nailfold capillaroscopy after consumption of Brazil nuts (15–25 g/day) in obese adolescents, observing a significant increase (13.9%) in average capillary blood flow and a 9.5% increase in maximum capillary blood flow in response to PORH after 16 weeks of supplementation , but these patients did not have any obesity‐associated disease.…”