Effects of Dietary Supplementation with Brazil Nuts on Microvascular Endothelial Function in Hypertensive and Dyslipidemic Patients: A Randomized Crossover Placebo‐Controlled Trial

Huguenin, Grazielle Vilas Bôas; Moreira, Annie Seixas Bello; Siant'Pierre, Tatiana D.; Gonçalves, Ramiro; Rosa, Glorimar; Oliveira, Gláucia Maria Moraes de; Luiz, Ronir Raggio; Tibiriçá, Eduardo

doi:10.1111/micc.12225

Cited by 24 publications

(22 citation statements)

References 46 publications

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“…12 It has been demonstrated that adequate tissue oxygen delivery is dependent on microcirculatory functioning, and thus, maintained tissue perfusion is a key indicator of injury and disease. 13 The pathophysiology of the skins' circulatory behavior has been studied in many popular fields such as peripheral artery diseases, 14 hypertension, 15 type 2 diabetes, 16 and primary aging. 17 Laser Doppler flowmetry (LDF) and laser Doppler perfusion imaging (LDPI) are commonly used, non-invasive methods to measure skin microcirculation.…”

mentioning

confidence: 99%

Perfusion of the skin’s microcirculation after cold‐water immersion (10°C) and partial‐body cryotherapy (−135°C)

Hohenauer

Deliens

Clarys

et al. 2019

Skin Research and Technology

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BackgroundInvestigations of the perfusion of the skin's microcirculation with laser speckle contrast imaging (LSCI) after cold treatments are rare. Therefore, the aim of this study was to compare the effects between cold‐water immersion (CWI) conduction and partial‐body cryotherapy (PBC) convection on perfusion of the microcirculation and skin temperature on the thigh.Materials and MethodsTwenty healthy males were randomly allocated to CWI (10°C for 10 minutes) or PBC (−60°C for 30 seconds, −135°C for 2 minutes). Perfusion and skin temperature measurements were conducted on the anterior thigh region up to 60 minutes post‐treatment.ResultsCold‐water immersion decreased perfusion of the microcirculation significantly compared to baseline values between 10 minutes (P = 0.003) and 30 minutes (P = 0.01) post‐treatment. PBC increased perfusion of the microcirculation and decreased skin temperature only at the first measurement interval (0 minute, both P = 0.01) post‐treatment. Additionally, local skin temperature was significantly decreased compared to baseline values only after CWI up to 30 minutes (P = 0.04) post‐treatment.ConclusionCold‐water immersion reduced local skin microcirculation and skin temperature while PBC only slightly increased the perfusion of the microcirculation immediately after the treatment. For cooling purposes, the conduction method seems superior compared to the convection method, assessed with a LSCI device.

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confidence: 99%

Perfusion of the skin’s microcirculation after cold‐water immersion (10°C) and partial‐body cryotherapy (−135°C)

Hohenauer

Deliens

Clarys

et al. 2019

Skin Research and Technology

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“…Protein carbonylation, lipid peroxidation, antioxidant enzymes activity, and nitric oxide bioavailability were assessed as described elsewhere . Briefly, oxidative damage to proteins was measured by quantifying carbonyl groups based on reaction with dinitrophenylhydrazine (Sigma™, St. Louis, MO, USA).…”

Section: Methodsmentioning

confidence: 99%

“…Protein carbonylation, lipid peroxidation, antioxidant enzymes activity, and nitric oxide bioavailability were assessed as described elsewhere. 28,29 Briefly, oxidative damage to proteins was measured by quantifying carbonyl groups based on reaction with dinitrophenylhydrazine (Sigma™, St. Louis, MO, USA). Carbonyl contents were determined from absorbance at 370 nm and total protein concentration was assayed using BCA assay kit (Bioagency™, Sao Paulo, SP, Brazil).…”

Section: Oxidative Stressmentioning

confidence: 99%

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Increased vascular function and superoxide dismutase activity in physically active vs inactive adults living with HIV

Lopes

Farinatti

Lopes

et al. 2018

Scandinavian Med Sci Sports

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This study compared macro‐ and microvascular endothelial function and redox status in active vs inactive HIV‐infected patients (HIVP) under antiretroviral therapy. Using a cross‐sectional design, macro‐ and microvascular reactivity, systemic microvascular density, and oxidative stress were compared between 19 HIVP (53.1 ± 6.1 year) enrolled in a multimodal training program (aerobic, strength and flexibility exercises) for at least 12 months (60‐minutes sessions performed 3 times/wk with moderate intensity) vs 25 sedentary HIVP (51.2 ± 6.3 year). Forearm blood flow during reactive hyperemia (521.7 ± 241.9 vs 361.4% ± 125.0%; P = 0.04) and systemic microvascular density (120.8 ± 21.1 vs 105.6 ± 25.0 capillaries/mm2; P = 0.03) was greater in active than inactive patients. No significant difference between groups was detected for endothelium‐dependent and independent skin microvascular vasodilation (P > 0.05). As for redox status, carbonyl groups (P = 0.22), lipid peroxidation (P = 0.86), catalase activity (P = 0.99), and nitric oxide levels (P = 0.72) were similar across groups. However, superoxide dismutase activity was greater in active vs inactive HIVP (0.118 ± 0.013 vs 0.111 ± 0.007 U/mL; P = 0.05). Immune function reflected by total T CD4 and T CD8 counts (cell/mm3) did not differ between active and inactive groups (P > 0.82). In conclusion, physically active HIVP exhibited similar immune function, but greater macrovascular reactivity, systemic microvascular density, and superoxide dismutase activity than inactive patients of similar age.

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“…The microcirculatory tests were performed after a 20-minute rest with the patients in a supine position in an environment with a controlled temperature (23 ± 1°C) approximately 60 minute after a light breakfast, according to a previously validated standard experimental protocol. [44][45][46][47] Endothelium-dependent microvascular reactivity was evaluated using a recently standardized and validated LSCI laser system 47 at a wavelength of 785 nm (PeriCam PSI system, Perimed, Järfälla, Sweden) combined with iontophoresis of acetylcholine (ACh) for the continuous and noninvasive measurement of cutaneous microvascular perfusion in arbitrary perfusion units (APUs). Endothelial-independent cutaneous microvascular reactivity was analyzed using the same system but combined with sodium nitroprusside (SNP) iontophoresis.…”

Section: Cutaneous Microva Scul Ar Re Ac Ti V It Ymentioning

confidence: 99%

Evaluation of systemic microvascular reactivity in adults with congenital heart disease

Marino

Lopes

Borges

et al. 2018

Congenital Heart Disease

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Adults with congenital heart disease present a higher baseline cutaneous microvascular blood flow than healthy controls and do not present systemic microvascular endothelial dysfunction. Nevertheless, endothelium-independent microvascular reactivity is blunted, suggesting an altered vascular smooth muscle response or vascular structural alterations. Finally, patients with a lower functional capacity presented a greater microvascular basal blood flow than subjects with a higher functional capacity.

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Effects of Dietary Supplementation with Brazil Nuts on Microvascular Endothelial Function in Hypertensive and Dyslipidemic Patients: A Randomized Crossover Placebo‐Controlled Trial

Cited by 24 publications

References 46 publications

Perfusion of the skin’s microcirculation after cold‐water immersion (10°C) and partial‐body cryotherapy (−135°C)

Perfusion of the skin’s microcirculation after cold‐water immersion (10°C) and partial‐body cryotherapy (−135°C)

Increased vascular function and superoxide dismutase activity in physically active vs inactive adults living with HIV

Evaluation of systemic microvascular reactivity in adults with congenital heart disease

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