Assessment of Minerals in Obesity-related Diseases in the Chandigarh (India) Population

Taneja, Satish Kumar; Mandal, Reshu

doi:10.1007/s12011-007-8035-1

Cited by 7 publications

(7 citation statements)

References 87 publications

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“…Yakinici et al [44] reported that copper concentration was significantly higher in the obesity group than in the normal group, whereas other studies reported no difference between two groups [45,46]. Furthermore, copper concentration in diabetes patients was found to be lower than that of normal group [47]. In most mammalian species, insulin is stored in the pancreatic β cells as Zn crystals [48].…”

Section: Discussionmentioning

confidence: 99%

Hair Tissue Mineral Analysis and Metabolic Syndrome

Park

Choi

Nam

2009

Biol Trace Elem Res

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Deficiency of minerals causes functional abnormality of enzymes, frequently resulting in metabolic disturbance. We investigated possible relationship between minerals and metabolic syndrome by analysis of hair tissue minerals. We selected 848 subjects older than 20 years of age at Ajou University Hospital from May 2004 to February 2007. We excluded the subjects who had cancers, steroid and thyroid medication, and incomplete record from the study. Finally, 343 subjects were eligible. We performed cross-sectional analysis for the relationship between minerals and metabolic syndrome. The contents of calcium, magnesium, and copper in the metabolic syndrome group were significantly lower than those of the normal group, whereas the amounts of sodium, potassium, and mercury in the metabolic syndrome group were significantly higher than those of the normal group. By dividing the subjects into quartile with the level of calcium, magnesium, and mercury concentrations, we carried out logistic regression analysis to study the subjects and found that the subjects in the third quartile of calcium and magnesium concentrations had significantly lower odds ratio (OR) of the metabolic syndrome compared with that of the lowest quartile group [OR = 0.30, confidence interval (CI) = 0.10-0.89; OR = 0.189, CI = 0.063-0.566] and that the subjects in the highest mercury quartile had significantly higher OR of the metabolic syndrome compared with that of the lowest mercury quartile group (OR = 7.35, CI = 1.73-31.1). As part of the metabolic syndrome, the optimal calcium and magnesium concentrations in hair tissue may reflect decreased risk of metabolic syndrome, whereas high mercury concentration in hair tissue may indicate increased risk of metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Hair Tissue Mineral Analysis and Metabolic Syndrome

Park

Choi

Nam

2009

Biol Trace Elem Res

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“…On the contrary, there are increasing evidences that excessive Zn in diet induces obesity, diabetes, dyslipidemia and hypertension in experimental animals [10]. Higher concentration of Zn and lower concentration of Cu, Mg and Mn in the tissues of human and some populations have been reported to link the ionic imbalance of nutritionally important elements to the etiology of diseases [11]. Moreover, excessive Zn intake by supplementation can impair immunologic function, interfere with metabolism of other essential minerals and other lipid indices [12].…”

Section: Introductionmentioning

confidence: 99%

Long Term Excessive Zn Supplementation Induced Oxidative Stress in Wistar Rats Fed on Semi-Synthetic Diet

Singh¹

2012

FNS

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The use of Zn as micronutrient in husbandry and agriculture practices and also in baby foods and multivitamin supplements have been increased during the last two decades. However, the effect of long term increasing Zn load on the oxidative stress in the body has not been worked so far. The supplementation of pharmacological dosage of Zn in otherwise Zn adequate diet was investigated with the aim if excess Zn in the diet triggers oxidative stress and its conesquence on enzymes of antioxidant defense system. In this study, three groups of rats were fed on semi-synthetic diet containing 20 mg Zn/kg (control, group-I), 40 mg Zn/kg (group-II) and 80 mg Zn/kg (group-III) diet respectively for a period of 6 months. Blood lipid profile in the serum, lipid peroxidation status and the activities of antioxidant enzymes and trace minerals level were estimated both in the liver and kidney of three groups of rats. The study revealed that the gain in body weight increased in rats in Zn concentration dependent manner. The blood lipid profile displayed a significant rise in serum glucose, total lipids, cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol whereas HDL-cholesterol showed a reduction in their levels in group-II and III than their control counter parts. The lipid peroxidation products were higher and the enzyme activities of superoxide dismutase, catalase, glutathione-s-transferase, glutathione reductase, glutathione (reduced) and glucose-6-phosphate dehydrogenase were significantly lowered in liver and kidney of group-II and group-III. Their mineral status revealed a higher Zn concentration and lower Cu, Mg and Mn both in liver and kidney. This data suggest that Zn in excess in diet when fed for longer periods of time induces oxidative stress by altering the status of minerals

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“…Some studies also showed that the status of minerals in the obesity-related diseases depend on the choice of the food consumed to improve the quality of life and prognosis of the diseases [25].…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Zinc, Copper, and Ceruloplasmin in Patients after Undergoing Laparoscopic Adjustable Gastric Banding

Böyük

Banlı²,

Gümüş

et al. 2011

Biol Trace Elem Res

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Laparoscopic adjustable gastric banding (LAGB) causes significant weight loss in morbidly obese adults. However, its consequences on nutritional status still remain unclear. There are a few studies determining the nutritional status after LAGB and none have focused on the serum levels of zinc (Zn), copper (Cu), and ceruloplasmin (CP). We aimed to investigate the effects of LAGB surgery on plasma Zn, Cu, and CP levels. Thirty patients with LAGB with morbid obesity were included. Blood samples were collected preooperatively and in the postoperative third month to determine plasma Zn, Cu, and CP levels. The mean preoperative and postoperative body mass indexes (BMI) were 44.9 ± 7.4 kg/m(2) and 44.1 ± 6.5 kg/m(2), respectively. The mean weight loss was 12.9 ± 3.3 kg at the postoperative third month. The postoperative Zn (500 ± 130 ng/ml), Cu (280 ± 80 ng/ml), and CP (23.9 ± 8.8 mg/dl) values were statistically significantly lower than the preooperative Zn (740 ± 230 ng/ml), Cu (370 ± 80 ng/ml) and CP (33.3 ± 15.7 mg/dl) levels (p < 0.05). Decreases in the plasma levels of Zn, Cu, and CP were seen postoperatively following LAGB surgery. The nutritional status of LAGB-applied patients should be monitored and mineral supplementation may be considered.

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Assessment of Minerals in Obesity-related Diseases in the Chandigarh (India) Population

Cited by 7 publications

References 87 publications

Hair Tissue Mineral Analysis and Metabolic Syndrome

Hair Tissue Mineral Analysis and Metabolic Syndrome

Long Term Excessive Zn Supplementation Induced Oxidative Stress in Wistar Rats Fed on Semi-Synthetic Diet

Plasma Levels of Zinc, Copper, and Ceruloplasmin in Patients after Undergoing Laparoscopic Adjustable Gastric Banding

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