Excellent response to mesotherapy as adjunctive treatment in male androgenetic alopecia

Abstract

Androgenetic alopecia (AGA) is the most common type of alopecia, affecting up to 80% of males and 50% of females. 1 It is a chronic, progressive, noncicatricial, androgen-dependent condition that affects genetically predisposed individuals, leading to progressive follicular miniaturization. Currently, only topical minoxidil and oral finasteride are approved for its treatment. 2 2 | C A S E REP ORT A 47-year-old healthy white male patient came to our clinic with a complaint of hair loss. On examination, the patient had diffuse thinning on his scalp hair and recession of the frontal and temporal hairline (Hamilton-Norwood Scale IV) without evidence of inflammation or scarring (Figure 1A). He had a positive family history of hair loss, and extensive laboratory analyses were unremarkable. We made the diagnosis of male pattern AGA, and we started the gold-standard treatment with minoxidil 5% topical solution twice daily and finasteride 1mg daily for 2 years, with improvement during this period. However, after that, the patient's clinical response stabilized and he requested hair transplantation. After a discussion of all treatment options, we added mesotherapy, a minimally invasive technique, to his previous treatment, postponing the need for an invasive procedure. The patient received 10 sessions of sterile injectable blend containing 1ml minoxidil 0,5%, 1ml finasteride 0,05%, 2ml biotin 5mg/ml, and 2ml D-panthenol 50mg/ml (Pineda®

Use of vibrating anesthetic device reduces the pain of mesotherapy injections: A randomized split‐scalp study

“…Pain due to injections can be reduced by tactile distraction with VAD 7 . Vibration rationale relies on the “gate control” theory of pain proposed by Melzack and Wall , which translates to the decrease of the intensity of pain by concurrent transmission of nonpainful stimuli, such as vibration 3,5,6,8,11 . The authors stated that the transmission of sense of vibration from mechanoreceptors located in the skin via A‐β nerve fibers results in the shutting down of a “gate” through which pain signals are transmitted to the brain through A‐δ and C fibers 3,7 …”

“…Once the drug is administered, it achieves a local, longer lasting effect. 8 Cold applications and topical anesthetic creams are frequently used for reducing pain discomfort. 10 However, especially for scalp procedures, these techniques are not well accepted for the patients.…”

“…Injectable mesotherapy for AGA may contain one or several drugs. Finasteride, minoxidil, panthenol, and biotin have been used in scalp mesotherapy 8 . Regarding AA, main therapeutic guidelines consider intralesional corticosteroids, a type of mesotherapy, as first‐line therapy in adults with AA involving less than 50% of the scalp 9 …”

“…Finasteride, minoxidil, panthenol, and biotin have been used in scalp mesotherapy. 8 Regarding AA, main therapeutic guidelines consider intralesional corticosteroids, a type of mesotherapy, as first-line therapy in adults with AA involving less than 50% of the scalp. 9 Even though these procedures can be easily undertaken in office-based settings, precautions must be taken to ensure patient comfort and safety.…”

Aesthetic dermatology procedures in coronavirus days

“…We use mesotherapy for skin rejuvenation, lifting, fat removal, skin pigmentation disorders, and alopecia 25 . Mesotherapy is sometimes responsible for dermal and subcutaneous infections caused by different infectious agents such as Mycobacterium chelonae, M. abscessus, and M. Fortuitum after cellulitis therapy 26 .…”