Evaluation the effect of CaO Nanoparticles on the body weight and Lipid factors in male Wister Rats

Al-Shaibani, Shurooq Wesam; Al-kelaby, Waleed J. A.; Abdulridha, Wasna’a M.; Hussein, Hayfaa Jaber; Al-Molla, Bushra Habeeb

doi:10.5958/0974-360x.2019.00913.2

Cited by 3 publications

(3 citation statements)

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“…CaO-NPs have been used for various biomedical applications such as drug delivery and antimicrobial agent [ 23 ]. In the literature, different animal studies found that the administration of CaO-NPs had a significant impact on the functioning of different body parts such as the liver, blood cholesterol, and body weight [ 18 ]. Using saturated gum with CaO-NPs was also found to be effective to induce remineralization of initial caries of extracted human teeth [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a comparative study, CaO-NPs were found to be less effective than calcium hydroxide nanoparticles in eliminating bacteria in the dentinal tubules [ 17 ]. These particles were also found to be effective in decreasing the triglyceride and cholesterol amount of blood in mice [ 18 ]. Other studies reported that regular supplementation of calcium over a longer period may reduce the risk of fractures in healthy individuals [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Studying Effects of Calcium Oxide Nanoparticles on Dentinogenesis in Male Wistar Rats

Al-Maula

Wally

Al-Magsoosi

et al. 2021

International Journal of Dentistry

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This study aimed to evaluate potential impacts of calcium oxide nanoparticles (CaO-NPs) at different dosages on predentin thickness, number of blood vessels, periodontal ligament thickness, and blood glucose level of Wistar rats. Twelve rats were randomly gathered into four groups, untreated (control) and CaO-NP-treated groups at three concentrations (25, 50, and 100 mg/kg of the body weight) over a period of 60 days. Histological investigation was performed on twenty-four lower incisor teeth extracted from all the tested groups under a light microscope, and an automatic Fujifilm was used to measure the blood glucose level. The results showed that regular nanoparticle treatment significantly increased predentin and periodontal ligament thicknesses, a gradual decrease in vascularization in the pulp tissue, and an increase in the blood glucose level as the dosages of nanoparticles administered to the rats increased. Administration of the CaO-NPs at low dosage (25 mg/kg) could be beneficial for the growth and integrity of teeth and dentinal tissues in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Studying Effects of Calcium Oxide Nanoparticles on Dentinogenesis in Male Wistar Rats

Al-Maula

Wally

Al-Magsoosi

et al. 2021

International Journal of Dentistry

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“…The CaO nanoparticles were prepared and characterized in accordance with Al-Shaibani et al [16].A suspension of CaO nanoparticles was prepared through the mixing of 10 ml highly purified water with 50 mg CaO nanoparticles powder. Artificial saliva was prepared following Madhuudana et al [14].…”

Section: Calcium Oxide Nanoparticle Suspension and Artificial Saliva Preparationmentioning

confidence: 99%

Recalcification of Carious Lesion with Aids of Calcium Oxide Nanoparticles

Al-Maula¹,

Al-Nasrawi²,

Yassir³

et al. 2020

ATMPH

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Application of CaO nanoparticles has been stated to have a promising effect in the increasing of the resistance of mineralized tissue against cryogenic challenge. This project aimed to investigate the recalcifying efficacy CaO nanoparticles applied to the natural lesion. Thirty enamel samples were prepared from premolar teeth. They were divided into two main groups of three subgroups in each (Sub-G1, Sub-G2, and Sub-G3), one group from the affected area and another from the adjacent sound area. The samples in Sub-G1 were coated with the bonding agent, in Sub-G2 were coated with CaO nanoparticles loaded bonding agent, and Su-G3 with no coating (control). After storage in artificial saliva, the mineral contents were quantified with aids of scanning electron microscope fitted with energy dispersive spectroscopy (SEM-EDX). The statistical analysis displayed an increase in the Ca surface contents of carious and sound samples in Sub-G2. This indicates that coating the enamel with CaO nanoparticles loaded bonding agent could enhance the remineralization of naturally demineralized hard tissue and provide protection for the sound tissue.

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