This study aimed to evaluate potential impacts of calcium oxide nanoparticles (CaO-NPs) at different dosages on predentin thickness, number of blood vessels, periodontal ligament thickness, and blood glucose level of Wistar rats. Twelve rats were randomly gathered into four groups, untreated (control) and CaO-NP-treated groups at three concentrations (25, 50, and 100 mg/kg of the body weight) over a period of 60 days. Histological investigation was performed on twenty-four lower incisor teeth extracted from all the tested groups under a light microscope, and an automatic Fujifilm was used to measure the blood glucose level. The results showed that regular nanoparticle treatment significantly increased predentin and periodontal ligament thicknesses, a gradual decrease in vascularization in the pulp tissue, and an increase in the blood glucose level as the dosages of nanoparticles administered to the rats increased. Administration of the CaO-NPs at low dosage (25 mg/kg) could be beneficial for the growth and integrity of teeth and dentinal tissues in rats.

The present study was conducted to evaluate the impact of calcium oxide-nanoparticles (CaO-NPs) administration at different concentrations on the epithelial thickness, papilla length and number of blood vessels of male Wister rats' buccal mucosa, and the epithelial thickness, filiform length and number of blood vessels of the rats' tongue. Twelve rats were used and randomly allocated into four groups: control group (untreated) and the three experimental groups were orally treated with CaO-NPs at different doses 25, 50 and 100 mg/kg of the body weight over two months. On the 61 st day, all the animals were sacrificed, and 1 cm of the buccal mucosa and the body of the tongue were carefully removed for histological analysis. Histological tissues were studied under a light microscope to investigate the impact of CaO-NPs administration on the oral tissues. An image processing software (Image J) was used to measure the epithelial thickness, papilla length and number of blood vessels of the rats' buccal mucosa, and the epithelial thickness, filiform length and number of blood vessels of the rats' tongue. The results showed that the CaO nanoparticles administration caused epithelial atrophy and decreased vascularization of buccal and tongue mucosa with all tested doses of CaO-NPs and the 100 mg/kg concentration showed the most significant effect.

No abstract

Application of CaO nanoparticles has been stated to have a promising effect in the increasing of the resistance of mineralized tissue against cryogenic challenge. This project aimed to investigate the recalcifying efficacy CaO nanoparticles applied to the natural lesion. Thirty enamel samples were prepared from premolar teeth. They were divided into two main groups of three subgroups in each (Sub-G1, Sub-G2, and Sub-G3), one group from the affected area and another from the adjacent sound area. The samples in Sub-G1 were coated with the bonding agent, in Sub-G2 were coated with CaO nanoparticles loaded bonding agent, and Su-G3 with no coating (control). After storage in artificial saliva, the mineral contents were quantified with aids of scanning electron microscope fitted with energy dispersive spectroscopy (SEM-EDX). The statistical analysis displayed an increase in the Ca surface contents of carious and sound samples in Sub-G2. This indicates that coating the enamel with CaO nanoparticles loaded bonding agent could enhance the remineralization of naturally demineralized hard tissue and provide protection for the sound tissue.

No abstract

No abstract