Background: radiotherapy for the treatment of head and neckcancer can produce damage to tissue and specifically salivary glands, causing an alteration in composition of saliva accompanied with oral mucositis. The present study was designed to investigate the changes in saliva components before and after irradiation in comparison to control. Methods: Sixty human male participate in this study. Thirty of them were patients with head and neck cancer prior to and after radiotherapy were evaluated for constituents of saliva and compared with other thirty free of cancer as a control group. Collection of 2ml of stimulated saliva with biochemical analysis of (buffering capacity, salivary amylase and salivary total protein) were done for all subjects. Results: the current findings show an increment in salivary flow rate for irradiate patients compared to control. while reduction in buffer capacity was observed in irradiate patient in comparison to control. Results for both salivary amylase and salivary total protein illustrated a reduction in their concentration before and after irradiation in comparison to control with significant difference value. Conclusion: Radiotherapy affects salivary glands causing alteration in biochemical components of saliva and may cause oral tissue damage.
Application of CaO nanoparticles has been stated to have a promising effect in the increasing of the resistance of mineralized tissue against cryogenic challenge. This project aimed to investigate the recalcifying efficacy CaO nanoparticles applied to the natural lesion. Thirty enamel samples were prepared from premolar teeth. They were divided into two main groups of three subgroups in each (Sub-G1, Sub-G2, and Sub-G3), one group from the affected area and another from the adjacent sound area. The samples in Sub-G1 were coated with the bonding agent, in Sub-G2 were coated with CaO nanoparticles loaded bonding agent, and Su-G3 with no coating (control). After storage in artificial saliva, the mineral contents were quantified with aids of scanning electron microscope fitted with energy dispersive spectroscopy (SEM-EDX). The statistical analysis displayed an increase in the Ca surface contents of carious and sound samples in Sub-G2. This indicates that coating the enamel with CaO nanoparticles loaded bonding agent could enhance the remineralization of naturally demineralized hard tissue and provide protection for the sound tissue.
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