Nanoscale calcium oxide and its biomedical applications: A comprehensive review

Kumari, Madhubala; Sarkar, Biplab; Mukherjee, Koel

doi:10.1016/j.bcab.2022.102506

Cited by 10 publications

(3 citation statements)

References 145 publications

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“…Because of the existence of oxygen vacancy defects at the surface of the nanoparticles, it was hypothesized that the mechanism of MgO nanoparticles' antibacterial effect would include lipid peroxidation and ROS ( Krishnamoorthy et al ., 2012 ). Our results contradicted those of Kumari et al . (2023 ), who reported that calcium oxide nanoparticles exhibited the maximum inhibition zone against E. coli .…”

Section: Discussioncontrasting

confidence: 99%

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Application of some inorganic metal oxide nanoparticles to control E. coli in raw milk

Nazem,

Shaala,

Awad

2024

Open Vet J

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Background: Nanoparticles are regarded as magical bullets because of their exclusive features. Recently, the usage of nanoparticles has progressed in almost all aspects of science and technology due to its ability of revolutionizing certain fields. In the field of food science and technology, the application of nanoparticles is being researched in many various areas thus provide the dairy industry a variety of new attitudes for developing the quality, prolong shelf life, ensure safety and healthiness of foods. Aim: This study aimed to focus on the application of some inorganic metal oxide nanoparticles (zinc oxide (ZnO), magnesium oxide (MgO), and calcium oxide (CaO)) to control E. coli in raw milk and ensure its safety. Methods: The antibacterial action of certain nanoparticles (ZnO, MgO, and CaO) with multiple concentrations (0.1, 0.05, 0.025, 0.0125, 0.006, and 0.003 mg/ml) was evaluated against E. coli strains in UHT milk samples. As well, storage temperature and storage period effects were studied. Results: The findings of the current research revealed that inorganic metal oxide nanoparticles had a significant antibacterial role against E. coli, at the following order; ZnO, MgO, and CaO, respectively. The antibacterial effect of inorganic metal oxide nanoparticles is more noticed at lower temperatures. Conclusion: Inorganic metal nanoparticles can be used in the food industry for the purpose of the control of E. coli, and extension of the shelf life of the dairy products.

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Section: Discussioncontrasting

confidence: 99%

“…When used at allowed concentrations, CaO nanoparticles are generally not harmful and remain stable in harsh environments. Because CaO nanoparticles have the ability to generate ROS, which ultimately causes microbial mortality, they may offer a therapeutic approach for inhibiting microbial growth ( Kumari et al ., 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Application of some inorganic metal oxide nanoparticles to control E. coli in raw milk

Nazem,

Shaala,

Awad

2024

Open Vet J

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“…Their small size enhances the interaction with pathogens making them highly effective antimicrobial agents. Types of antimicrobial nanoparticles include silver nanoparticles which disrupt bacterial cell membranes and damage intracellular structures [ 22 ], zinc oxide nanoparticles which produce reactive oxygen species (ROS) elevating membrane lipid peroxidation that causes membrane leakage of reducing sugars, DNA, proteins, and reduces cell viability [ 23 ]; copper nanoparticles generate ROS, disrupt microbial cell walls and membranes, and interact with proteins and DNA [ 24 ]; the calcium oxide nanoparticles produce free radicals that damage bacterial cell membrane and the arrangement of polyunsaturated phospholipids [ 25 ]; and titanium dioxide nanoparticles which possess photocatalytic properties generating antimicrobial reactive oxygen species [ 26 ].…”

Section: Sources Of Antimicrobialsmentioning

confidence: 99%

Methods for screening and evaluation of antimicrobial activity: A review of protocols, advantages, and limitations

Hossain

2024

EuJMI

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Infectious diseases pose a formidable global challenge, compounded by the emergence of antimicrobial resistance. Consequently, researchers are actively exploring novel antimicrobial compounds as potential solutions. This endeavor underscores the pivotal role of methods employed for screening and evaluating antimicrobial activity—a critical step in discovery and characterization of antimicrobial agents. While traditional techniques such as well-diffusion, disk-diffusion, and broth-dilution are commonly utilized in antimicrobial assays, they may encounter limitations concerning reproducibility and speed. Additionally, a diverse array of antimicrobial assays including cross-streaking, poisoned-food, co-culture, time-kill kinetics, resazurin assay, bioautography, etc., are routinely employed in antimicrobial evaluations. Advanced techniques such as flow-cytometry, impedance analysis, and bioluminescent technique may offer rapid and sensitive results, providing deeper insights into the impact of antimicrobials on cellular integrity. However, their higher cost and limited accessibility in certain laboratory settings may present challenges. This article provides a comprehensive overview of assays designed to characterize antimicrobial activity, elucidating their underlying principles, protocols, advantages, and limitations. The primary objective is to enhance understanding of the methodologies designed for evaluating antimicrobial agents in our relentless battle against infectious diseases. By selecting the appropriate antimicrobial testing method, researchers can discern suitable conditions and streamline the identification of effective antimicrobial agents.

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Plant mediated synthesis of CaO nano-particles and investigation of morphological, spectroscopic, electrical, and catalytic properties

Lalithamba,

Siddekha,

Rashmi

et al. 2023

J Mater Sci: Mater Electron

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Nanoscale calcium oxide and its biomedical applications: A comprehensive review

Cited by 10 publications

References 145 publications

Application of some inorganic metal oxide nanoparticles to control E. coli in raw milk

Application of some inorganic metal oxide nanoparticles to control E. coli in raw milk

Methods for screening and evaluation of antimicrobial activity: A review of protocols, advantages, and limitations

Plant mediated synthesis of CaO nano-particles and investigation of morphological, spectroscopic, electrical, and catalytic properties

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