Evaluation of the Phytochemical, Antioxidant, Antibacterial and Anticancer Activity of Prunus domestica Fruit

Abstract

Plants have been used long ago through man history of life for their use in food and medicinal drives. In modern life, natural products have been extracted and isolated from several kinds of plants for the development of new drugs. There are numerous interests in natural antioxidants extracted from medicinal plants, vegetables and fruits, which might help to prevent oxidative damage. One of such plants is plum Prunus domestica L., family Rosaceae. Samples from ‘African Rose’, and ‘Santa Rosa’ plum cultivars were collected from local market in Giza governorate, Egypt. The main phytochemicals of plums (fruit flesh and skin) were analyzed. Total polyphenols, flavonoids, tannins, anthocyanins, and reducing power were higher in ‘African Rose’ fruit. The ethanolic and ethyl acetate extracts of two plum cultivars were both high in the antioxidant effect with IC50 13.923 and 18.416 μg/ml of ethanolic extract of ‘African Rose’, and ‘Santa Rosa’ respectively. The IC50 of ‘African Rose’ and ‘Santa Rose’ extract against Caco-2 was 4 and 8.5 μg/ml. GC-MS analysis was carried out, fourteen and twenty one compound were identified in ‘Santa Rosa’ and ‘African Rose’ respectively. The fruits had an antimicrobial action against gram positive and negative bacteria. There was anticancer activity against 3 cell lines: Liver cell line (HepG2), colorectal adenocarcinoma (Caco-2) cell line, and breast cell line (MCF-7).

Polyphenolic QTOF-ESI MS Characterization and the Antioxidant and Cytotoxic Activities of Prunus domestica Commercial Cultivars from Costa Rica

“…When comparing with literature reports, our results show a larger number of compounds than those reported for whole plum fruits from Egypt, USA, Serbia and Romania [16,[28][29][30] in flavan-3-ols and HCA, as well as similar results in flavonoids to those found for Egyptian cultivars [29]. Within studies focused on plum skins, our results show a greater number of compounds than cultivars from the USA and Germany [7,31].…”

Analyzing Biological Properties of Some Plum Genotypes Grown in Turkey

“…Saraswathi et al (2020) also recorded the antibacterial effect of Prunus cerasifera extracts showed antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Proteus vulgaris, and Escherichia coli. In a similar study, the antibacterial activity of Prunus domestica fruits was found positive on both Gr (+) and Gr (-) bacteria (El-Beltagi et al, 2019). In another report, the antibacterial effect of dry and fresh plum extracts showed antibacterial effect against Staphylococcus aureus and Escherichia coli (Belhadj and Marzouki, 2014).…”

Effect of Gamma irradiation on some biochemical properties, antioxidant and antimicrobial activities of Sakouti and Bondoky dry dates fruits genotypes

“…Several studies have revealed a direct relationship between the antioxidant activity and phenolic content on several date fruits (Allaith, 2008). Antioxidants in date fruits may save the body from many degenerative disorders by reducing oxidative stress owing to; (a) the phenolic compounds that suppresses nucleic acids, proteins and lipids oxidative damage (El-Beltagi, El-Ansary, Mostafa, Kamel, & Safwat, 2019b;El-Beltagi, Mohamed, Elmelegy, Eldesoky, & Safwat, 2019a;Nasir et al, 2015) and (b) activating of both enzymatic and non-enzymatic antioxidant systems (Borochov-Neori et al, 2015). Dates are classified by their moisture content, more than 30% of the soft date consists of moisture.…”