Evaluation of the gastric retention properties of a cross-linked polymer coated tablet versus those of a non-disintegrating tablet

Agyilirah, George A.; Green, Mark; duCret, Rene P.; Banker, Gilbert S.

doi:10.1016/0378-5173(91)90198-w

Cited by 44 publications

(29 citation statements)

References 9 publications

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“…In the dissolution media themembrane detached from the core and sweeled to forma balloon that kept the unit floating. the size of theunits increased by three to six folds, thus the floatingability as well as the increased dimension offered thesystem gastroretentive property [40] Fig.14: Swelling system 5) Superporous hydrogels These are swellable systems that differ from conventional types. Absorption of water by conventional hydrogel is very slow process and several hours may be required to reach the equilibrium states [41] during which the premature evacuation of the dosage form may occur.…”

Section: ) Swelling Systemmentioning

confidence: 99%

A review: Gastroretentive drug delivery system (grdds)

Jassal

Nautiyal

Kundlas

et al. 2015

ijpbr

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One novel approach in this area is GRDDSs (Gastro Retentive Drug Delivery System). GRDDSs can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site.The purpose of writing this review was to investigate, compile and present the recent as well as past literatures in more concise way with special focus on approaches which are currently utilized in the prolongation of gastric residence time. These includes floating system, swelling and expanding system, bio/mucoadhesive system, high density system and other delayed gastric emptying devices. The present review addresses briefly about the classification, formulation consideration for GRDDS, factors controlling gastric retention, merits, demerits and applications of gastroretentive drug delivery systems.

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Section: ) Swelling Systemmentioning

confidence: 99%

A review: Gastroretentive drug delivery system (grdds)

Jassal

Nautiyal

Kundlas

et al. 2015

ijpbr

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“…Gastric retention devices may be extremely useful for the delivery of many drugs. Such devices would be most beneficial for drugs that act locally in the stomach (e.g., antacids and antibiotics for bacteria-based ulcers), or for those drugs that are primarily absorbed in the stomach (Agyilirah et al 1991). For drugs that have a narrow absorption window (i.e., mainly absorbed from the proximal small intestine), such as riboflavin, levodopa, p-aminobenzoic acid (Ichikawa et al 1991a, b), a controlled release in the stomach would improve bioavailability.…”

Section: Gastric Retention Devicesmentioning

confidence: 99%

Recent developments in superporous hydrogels

Omidian¹,

Park

Rocca³

2007

Journal of Pharmacy and Pharmacology

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Superporous hydrogels (SPHs) were originally developed as a novel drug delivery system to retain drugs in the gastric medium. These systems should instantly swell in the stomach and maintain their integrity in the harsh stomach environment, while releasing the pharmaceutical active ingredient. For years, the synthetic features and properties of these SPH materials have been modified and improved to meet the requirements for gastric retention applications. Furthermore, an instant swelling hydrogel has also shown potential application for peroral intestinal peptide and protein absorption. This review discusses the formulation, characterization, properties and applications of these polymers.

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“…Aspirin, Chloropheniramine malate, Griseofulvine [45] , p-nitroaniline [46] , Ibuprofen [47] , Terfenadine [48] , Tranilast [49] , Verapramil HCL. [50] Acetylsalicylic acid [51] , Ibuprofen, Amoxycillin trihydrate [52] , Ampicillin [53] , Sotalol [54] , Isosorbidemononitrate [55] , Tranilast [56] , Captropril [57] , Ciprofloxacin [58] , Qunidine [59] , Acetaminophen [60] , Diltiazem. [61] 2.…”

Section: Raft Systemsmentioning

confidence: 99%

Recent Trends in Gastroretentive Floating Drug Delivery System-a Review

Upadhyay¹

2017

WJPR

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Gastro retentive drug delivery system have been a significant approach over the past few years to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract for local or systemic effect. Conventional oral dosage forms having low bioavailability problems due to their rapid gastric transition from stomach, in case of drugs which are less soluble at alkaline pH of intestine. Further drugs which produce their local action in stomach, get rapidly emptied do not get enough residence time in stomach.Hence, the frequency of dose administration in such cases is increased.To avoid these problems, various efforts have been made to prolong the retention time of drug in stomach. Floating system has been considered as imperative categories of drug delivery system which has gastric retentive behaviour. FDDS is lowdensity systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The review article explain the various floating drug delivery system that are formulated in order to enhance the drug bioavailability, reduce drug wastage & provide controlled drug delivery & better patient compliant. Several approaches & techniques were developed in recent years for FDDS are discussed.

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Evaluation of the gastric retention properties of a cross-linked polymer coated tablet versus those of a non-disintegrating tablet

Cited by 44 publications

References 9 publications

A review: Gastroretentive drug delivery system (grdds)

A review: Gastroretentive drug delivery system (grdds)

Recent developments in superporous hydrogels

Recent Trends in Gastroretentive Floating Drug Delivery System-a Review

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