A review: Gastroretentive drug delivery system (grdds)

Abstract

One novel approach in this area is GRDDSs (Gastro Retentive Drug Delivery System). GRDDSs can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site.The purpose of writing this review was to investigate, compile and present the recent as well as past literatures in more concise way with special focus on approaches which are currently utilized in the prolongation of gastric residence time. These includes floating system, swelling and expanding system, bio/mucoadhesive system, high density system and other delayed gastric emptying devices. The present review addresses briefly about the classification, formulation consideration for GRDDS, factors controlling gastric retention, merits, demerits and applications of gastroretentive drug delivery systems.

An overview on various types of gastroretentive drug delivery system

“…Following are the disadvantages of gastro retentive drug delivery system: -Floating drug delivery systems require high fluid level in stomach to float and work effectively [1] -Drugs that absorb selectively in colon, e.g. corticosteroids [1] -Drugs that have very limited acid solubility (e.g. phenytoin)…”

“…Frequency of food ingestion -When food is ingested frequency, GRT increase subsequently. This happens due to low frequency of migrating myoelectric cycle [1].…”

“…It also helps in reducing the drug concentration variation in plasma. In spite of having many advantages, this dosage form suffers number of disadvantages such as unpredictable gastric emptyingtime, variation of gastric emptying time from person to person, small gastrointestinal transit time (8-12 h), and number of drugs have absorption windows in upper part of small intestine [1]. The formulation scientists have to take care of these many number of challenges while designing a gastro retentive drug delivery systems.…”

“…Apart from this the main challenge that one face is of shorter gastric residence time (GIT), which is unpredictable and changes depending on number of factors. To be able to design GRDDS in a better way, a thorough knowledge and understanding of anatomy and physiology of GIT is necessary [2]. Gastric emptying states were fed along with fasting.…”

Development and radiographical evaluation of floating tablets with combination of Amoxicillin Trihydrate and Ranitidine Hydrochloride

“…Oral administration of drugs got upper hand in drug delivery systems (Meenakshi Jassal et al, 2015). During the past decades, many oral conventional drug delivery systems have been formulated and prepared to act as drug carrier and reservoir from which the active pharmaceutical ingredient can be released.…”