2003
DOI: 10.1097/00042728-200312000-00003
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Evaluation of the Efficacy of Polidocanol in the Form of Foam Compared With Liquid Form in Sclerotherapy of the Greater Saphenous Vein

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Cited by 38 publications
(41 citation statements)
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“…Two ml of POL (Aetoxysclerol® tamponné/lauromacrogol 400 (Kreussler Pharma, Germany) were used at 0.3% and 8 ml of air. Pumping and passing from one syringe to the other 15 times, produces stable micro-foam following the Tessari technique (Cavezzi et al, 2002;Frullini, 2000;Hamel-Desnos et al, 2003;Tessari, 2001;Tessari et al 2001;Wollmann, 2004). The resulting foam is rich in nitrogen, with an irregular bubble size and a highly internal cohesion (Redondo and Cabrera , 2005).…”
Section: Methodsmentioning
confidence: 99%
“…Two ml of POL (Aetoxysclerol® tamponné/lauromacrogol 400 (Kreussler Pharma, Germany) were used at 0.3% and 8 ml of air. Pumping and passing from one syringe to the other 15 times, produces stable micro-foam following the Tessari technique (Cavezzi et al, 2002;Frullini, 2000;Hamel-Desnos et al, 2003;Tessari, 2001;Tessari et al 2001;Wollmann, 2004). The resulting foam is rich in nitrogen, with an irregular bubble size and a highly internal cohesion (Redondo and Cabrera , 2005).…”
Section: Methodsmentioning
confidence: 99%
“…A single injection (the protocol did not include further injections) of 2 to 2.5 mL of double‐syringe‐system foam or 3% liquid polidocanol showed a 2‐year occlusion rate of 84% in the foam group versus 40% in the fluid group. Vasospasm was clearly more frequent and more pronounced in the group treated with foam (mean length 28 cm) than in the control group, the rate of side effects being identical 11,12 …”
Section: Resultsmentioning
confidence: 96%
“…The efficacy of the foam generated by agitation of the syringe or drug vial was increased approximately 3.5‐ to 4‐fold compared with the same amount of “conventional” fluid. The observation of a “marked vasospasm” after injection of foam is nowadays considered to be an important immediate end point for the assessment of the efficacy of modern sclerotherapy 11–13 . This (reversible) vasospasm, which is often clearly detectable in duplex‐guided sclerotherapy, can be considered to be a sign of initial vascular damage after sclerotherapy.…”
Section: Resultsmentioning
confidence: 99%
“…This normally occurs within 10-30 s after foam injection, although in some cases it is only seen after several minutes. There is no consensus as to whether the magnitude of the venospasm correlates with the quality of the sclerosing foam (Hamel-Desnos 2003). Usually, the venospasm is so intense that it compresses the foam column, causing an even spread along the incompetent vein segment (Fig.…”
Section: Ultrasound Evaluation Of the Sclerosant Reactionmentioning
confidence: 99%