Applications of Polidocanol in Varicose Vein Treatment Assisted by Exposure to Nd:YAG Laser Radiation

Smarandache, Adriana; Moraga, Javier Moreno; Staicu, Angela; Trelles, Mario A.; Pascu, Mihail-Lucian

doi:10.5772/34654

Cited by 6 publications

(7 citation statements)

References 44 publications

(53 reference statements)

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“…9 of 17 have explicitly reported the surface characteristics of POL solutions, and there is some variability in the reported data. Most of the works have only reported the surface tension values of the concentrations used by practitioners (0.5-3%) [11,36]. For instance, our values coincided with those reported by Nastasa et al (around 30 mN/m) for the saturated surface [8], whereas they differed from those reported by Rial et al (around 55 mN/m) for the saturated surface under similar conditions [22].…”

Section: Surface Tensionsupporting

confidence: 77%

“…Only few works have explicitly reported the surface characteristics of POL solutions, and there is some variability in the reported data. Most of the works have only reported the surface tension values of the concentrations used by practitioners (0.5-3%) [11,36] [37]. Accordingly, none of them displayed the lower concentration region with the stepwise behavior.…”

Section: Surface Tensionmentioning

confidence: 99%

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Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy

et al. 2020

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The use of foams to deliver bioactive agents and drugs is increasing in pharmaceutics. One example is the use of foam as a delivery system for polidocanol (POL) in sclerotherapy, with the addition of bioactive compounds to improve the delivery system being a current subject of study. This work shows the influence of two bioactive additives on the structure and stability of POL foam: hyaluronic acid (HA) and Pluronic-F68 (F68). HA is a natural non-surface-active biopolymer present in the extracellular matrix while F68 is a surface-active poloxamer that is biocompatible with plasma-derived fluids. Both additives increase the bulk viscosity of the sample, improving foam stability. However, HA doubled and F68 quadruplicated the foam half lifetime of POL. HA reduced the size and polydispersity of the bubble size distribution and increased the surface elasticity with respect to POL. Both facts have a positive impact in terms of foam stability. F68 also altered bubble structure and increased surface elasticity, again contributing to the enhancement of foam stability. The surface characterization of these systems is important, as in foam sclerotherapy it is crucial to assure the presence of POL at the surface of the bubbles in order to deliver the sclerosant agent in the target vein.

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Section: Surface Tensionsupporting

confidence: 77%

Section: Surface Tensionmentioning

confidence: 99%

Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy

et al. 2020

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“…Many variables can affect the stability of sclerosing foams produced by the Tessari method, such as the type of the detergent, solution concentration, the number of pumping cycles, the liquid-gas ratio, and any chemicals used for the foam production. 8 Recently, the foam stability was successfully improved by adding HA to POL solutions. The reason why HA can improve foam longevity is not well understood.…”

Section: Discussionmentioning

confidence: 99%

“…7 Ideally, foam should be sufficiently stable to avoid its destructuration during injection ensuring the sclerosing action against the endothelial, but it should dissipate quickly upon injection, limiting local and systemic undesired events. 8 Foam half-life, or the time until half of the liquid used to produce the foam reverts to the liquid state, was used as the parameter to quantify the foam stability in this manuscript. However, previous authors have developed systems for characterizing foams in a more clinically relevant scenario, introducing new measurement parameters such as the degradation rate and dwell time that allow the evaluation of the stability from a mechanical standpoint.…”

Section: Introductionmentioning

confidence: 99%

Effects of sulodexide on stability of sclerosing foams

et al. 2018

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Background and objectives Foam sclerotherapy is a clinical procedure for the treatment of unhealthy veins. The aim of this study was to investigate the effect of sulodexide (SUL) on stability of foams prepared using polidocanol (POL) and sodium tetradecyl sulfate (STS) detergents, more specifically with 0.25% aethoxysclerol and 0.2% Fibro-Vein sclerosing solutions. Methods Foams were produced by the Tessari method using three different weight ratios of POL-SUL and STS-SUL (1:0, 1:1, and 1:3). Results The half-life of STS foams resulted as follows: 82 ± 1.6 s, 101.8 ± 2.6 s, and 109.7 ± 2.1 s for 1:0, 1:1, and 1:3 STS-SUL weight ratios, respectively. The same ratios were used for POL foams with the following results: 90.6 ± 3 s, 106.8 ± 2.6 s, and 107.6 ± 2.7 s for 1:0, 1:1, and 1:3 POL-SUL weight ratios, respectively. Conclusion The addition of SUL in sclerosing solutions can prolong the half-life of foams, and it could be potentially used as a foam stabilizer.

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“…The experimental set-up for Raman measurements is described in detail elsewhere [45][46][47]. Raman spectra were collected for the 600-1800 cm −1 and 800-5000 cm −1 spectral ranges, with a resolution of 0.3 nm, and was averaged on 2000 or 3000 signals.…”

Section: Methodsmentioning

confidence: 99%

Spectroscopic Characterization of Emulsions Generated with a New Laser-Assisted Device

et al. 2020

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This paper presents a spectroscopic study of emulsions generated with a laser-assisted device. Fourier transform infrared (FTIR), Raman and UV–Vis–NIR reflectance spectra of emulsions, recorded before and after exposure to laser radiation were used to characterize the effect of laser irradiation. The paper also presents a comparison between the calculated IR spectra and the experimental FTIR spectra of an emulsion’s components. FTIR measurements allowed the identification of absorption bands specific to each of the emulsions’ components. Moreover, it enabled the observation of destabilization of the emulsion in real-time. Raman spectroscopy allowed the observation of the modifications at a molecular level, by identifying the vibrations of the representative functional groups and the polymerization of sodium tetradecyl sulfate (STS) molecules by analyzing the evolution of the carbonyl band. UV–Vis–NIR reflectance spectra of emulsions before and after exposure to laser radiation showed that the physical characteristics of the emulsions changed during irradiation—the dimensions of the droplets decreased, leading to an emulsion with a better time stability. These results proved that the employed spectroscopy techniques were powerful tools in emulsion analysis.

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Applications of Polidocanol in Varicose Vein Treatment Assisted by Exposure to Nd:YAG Laser Radiation

Cited by 6 publications

References 44 publications

Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy

Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy

Effects of sulodexide on stability of sclerosing foams

Spectroscopic Characterization of Emulsions Generated with a New Laser-Assisted Device

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