Effects of sulodexide on stability of sclerosing foams

Critello, Costantino Davide; Fiorillo, Antonino S.; Cristiano, Maria Chiara; Franciscis, Stefano de; Serra, Raffaele

doi:10.1177/0268355518779844

Cited by 12 publications

(7 citation statements)

References 36 publications

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“…Various nano- and micro-particles have been extensively researched for antimicrobial, anti-inflammatory, antioxidant, and anticancer effect [ 28 , 29 , 30 ]. Among them, the AgNPs are well known to have anti-bacterial and anti-inflammatory activities [ 22 , 23 , 24 , 28 , 29 , 30 ]. In our in vivo study, the degree of stent-induced tissue hyperplasia was significantly less in the AgNP-coated SEMS groups than in the control group at four weeks after stent placement, which correlated with the histological findings.…”

Section: Discussionmentioning

confidence: 99%

Metallic Stent Mesh Coated with Silver Nanoparticles Suppresses Stent-Induced Tissue Hyperplasia and Biliary Sludge in the Rabbit Extrahepatic Bile Duct

et al. 2020

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Recent therapeutic strategies to suppress restenosis after biliary stent placement are insufficient. Here, we demonstrate the usefulness of a self-expandable metal stent (SEMS), a stent mesh coated with silver nanoparticles (AgNPs), for suppression of both stent-induced tissue hyperplasia and biliary sludge formation in the rabbit bile duct. The AgNP-coated SEMSs were prepared using a simple bio-inspired surface modification process. Then, the prepared SEMSs were successfully placed in 22 of 24 rabbits. Sludge formation in the AgNP-coated SEMS groups was significantly decreased compared to the control group on gross findings. Cholangiographic and histologic examinations demonstrated significantly decreased tissue hyperplasia in the AgNP-coated SEMS groups compared with the control group (p < 0.05 for all). There were no differences between the AgNP-coated SEMS groups (p > 0.05 for all). However, in the group coated with the greatest concentration of AgNPs (Group D), submucosal fibrosis was thicker than in the other AgNP-coated groups (p < 0.05 for all). The AgNP-coated metallic stent mesh significantly suppressed stent-induced tissue hyperplasia and biliary sludge formation in the rabbit bile duct. Taken together, the AgNP coating strategy developed in this study could be widely utilized in non-vascular medical devices for anti-bacterial and anti-inflammatory responses.

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Section: Discussionmentioning

confidence: 99%

Metallic Stent Mesh Coated with Silver Nanoparticles Suppresses Stent-Induced Tissue Hyperplasia and Biliary Sludge in the Rabbit Extrahepatic Bile Duct

et al. 2020

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“…Frequency sweep measurements were then applied between 0.1 and 100 Hz by keeping the strain constant at 1% in order to obtain rheological parameters such as storage or elastic modulus (G′) and loss or viscous modulus (G″) of zein-based gels. Furthermore, the viscosity profiles of samples as a function of shear rate in the range of 0.1–100 s −1 were determined [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels

et al. 2020

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The controlled release of a compound entrapped in a biocompatible formulation is a sought-after goal in modern pharmaceutical technology. Zein is a hydrophobic protein which has several advantageous properties that make it suitable for use as a biocompatible and degradable material under physiological conditions. It is, therefore, proposed for different biomedical and pharmaceutical applications. In particular, due to its gelling properties, it can be used to form a polymeric network able to preserve biomolecules from harsh environments. The current study was designed to investigate the influence of different probes on the rheological properties of gels made up of zein, in order to characterize the systems as a function of the polymer concentration. Four model compounds characterized by different physico-chemical properties were entrapped in zein gels, and different behaviors (viscoelastic or pronounced solid-like characteristics) of the systems were observed. Zein-based gels showed various release profiles of the encapsulated compounds, suggesting that there are different interaction rates between the probes and the polymeric matrix.

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“…176 In 2019, data showed that adding drugs such as sulodexide to polidocanol or sodium tetradecyl sulfate can even lead to a foam half-life prolongation. 177 A potential step-forward in foam sclerotherapy homogeneity has been offered by the non-physician-compounded polidocanol endovenous microfoam (Varithena V R ), whose efficacy and safety appeared to be equivalent or even better than physician-compounded foam. Nevertheless, the comparison was done against placebo and with only 1% concentration.…”

Section: Significant New Data Reported At the Meetingmentioning

confidence: 99%

Global guidelines trends and controversies in lower limb venous and lymphatic disease

et al. 2019

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Guidelines are fundamental in addressing everyday clinical indications and in reporting the current evidence-based data of related scientific investigations. At the same time, a spatial and temporal issue can limit their value. Indeed, variability in the recommendations can be found both among the same nation different scientific societies and among different nations/continents. On the other side, Garcia already published in 2014 data showing how, after three years in average, one out of five recommendations gets outdated (Martinez Garcia LM, Sanabria AJ, Garcia Alvarez E, et al. The validity of recommendations from clinical guidelines: a survival analysis. CMAJ 2014;186(16):1211–1219). The present document reports a narrative literature revision on the major international recommendations in lower limb venous and lymphatic disease management, focusing on the different countries’ guidelines, trends and controversies from all the continents, while identifying new evidence-based data potentially influencing future guidelines. World renowned experts’ opinions are also provided. The document has been written following the recorded round tables scientific discussions held at the vWINter international meeting (22–26 January 2019; Cortina d’Ampezzo, Italy) and the pre- and post-meeting literature search performed by the leading experts.

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Effects of sulodexide on stability of sclerosing foams

Cited by 12 publications

References 36 publications

Metallic Stent Mesh Coated with Silver Nanoparticles Suppresses Stent-Induced Tissue Hyperplasia and Biliary Sludge in the Rabbit Extrahepatic Bile Duct

Metallic Stent Mesh Coated with Silver Nanoparticles Suppresses Stent-Induced Tissue Hyperplasia and Biliary Sludge in the Rabbit Extrahepatic Bile Duct

Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels

Global guidelines trends and controversies in lower limb venous and lymphatic disease

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