Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels

Gagliardi, Agnese; Voci, Silvia; Paolino, Donatella; Fresta, Massimo; Cosco, Donato

doi:10.3390/molecules25143174

Cited by 21 publications

(13 citation statements)

References 42 publications

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“…Plant-derived polymers occur abundantly in nature and generally exhibit less immunogenicity than polymers of animal origin. Although cellulose, starch, soy protein, and zein, are the most widely used plant-derived polymers, numerous other plant-based polymers have been studied and have shown excellent results in drug delivery research ( George and Suchithra, 2019 ; Iravani and Varma, 2019 ; Gagliardi et al, 2020a , 2020b ).…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

et al. 2021

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Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate the pharmacological and biopharmaceutical properties of drugs. The peculiar physico-chemical and technological properties of nanomaterial-based therapeutics have allowed for several successful applications in the treatment of cancer. The size, shape, charge and patterning of nanoscale therapeutic molecules are parameters that need to be investigated and modulated in order to promote and optimize cell and tissue interaction. In this review, the use of polymeric nanoparticles as drug delivery systems of anticancer compounds, their physico-chemical properties and their ability to be efficiently localized in specific tumor tissues have been described. The nanoencapsulation of antitumor active compounds in polymeric systems is a promising approach to improve the efficacy of various tumor treatments.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

et al. 2021

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“…Protein gelation involves denaturation and aggregation processes. In detail, the first phenomenon is based on the perturbation of the native polymer conformation (unfolding), resulting in the exhibition of new reactive sites that are successively exploited in the aggregation step to promote various interactions, novel structures of greater molecular weight and then an ordered network [86,[152][153][154]. As was previously reported in the case of polysaccharides, the variation of several experimental approaches can be used to trigger the unfolding of the protein, such as chemical forces (ionic strength, enzymes) or physical parameters (temperature, pressure) [155,156].…”

Section: Protein-based Hydrogelsmentioning

confidence: 99%

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Voci

Gagliardi

Molinaro

et al. 2021

Gels

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The discovery of paclitaxel (PTX) has been a milestone in anti-cancer therapy and has promoted the development and marketing of various formulations that have revolutionized the therapeutic approach towards several malignancies. Despite its peculiar anti-cancer activity, the physico-chemical properties of PTX compromise the administration of the compound in polar media. Because of this, since the development of the first Food and Drug Administration (FDA)-approved formulation (Taxol®), consistent efforts have been made to obtain suitable delivery systems able to preserve/increase PTX efficacy and to overcome the side effects correlated to the presence of some excipients. The exploitation of natural polymers as potential materials for drug delivery purposes has favored the modulation of the bioavailability and the pharmacokinetic profiles of the drug, and in this regard, several formulations have been developed that allow the controlled release of the active compound. In this mini-review, the recent advances concerning the design and applications of natural polymer-based hydrogels containing PTX-loaded biocompatible nanocarriers are discussed. The technological features of these formulations as well as the therapeutic outcome achieved following their administration will be described, demonstrating their potential role as innovative systems to be used in anti-tumor therapy.

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“…Recently, our research team investigated the crucial role exerted by the nature of a compound entrapped in gels made up of 20% w/v of zein [31]. In particular, it was shown that the rheological features, as well as the leakage profile from the tridimensional network, were modulated by the physico-chemical features of the entrapped molecule.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, it was shown that the rheological features, as well as the leakage profile from the tridimensional network, were modulated by the physico-chemical features of the entrapped molecule. This happened as a consequence of the different interactions occurring between the vegetal protein and the payload, demonstrating the possibility of tailoring the technological properties of the formulation as a function of the required outcome [31].…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, brilliant blue R (BB) and disodium fluorescein (DF), two fluorescent dyes commonly used to mark proteins [32] and to study drug transport in the liver [33], respectively, were used as models of hydrophilic compounds. In addition, rutin and methylene blue (MB), molecules characterized by antioxidant [34] and antibacterial [31] properties, were exploited as amphiphilic and lipophilic model compounds, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Influence of the Physico-Chemical Properties of Model Compounds on the Mean Sizes and Retention Rate of Gliadin Nanoparticles

2021

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Vegetal proteins have emerged as appealing starting materials for the development of various drug delivery systems, and their use for obtaining polymeric nanoparticles has been profitably exploited in multidisciplinary fields. Wheat gliadin, the water-insoluble storage protein of gluten, is characterized by a great amount of hydrophobic amino acid residues and notable mucoadhesive features. This biopolymer can be easily manipulated to form colloidal carriers, films and fibers by means of bio-acceptable solvents and easy preparation procedures. In this investigation, four model compounds characterized by different octanol/water partition coefficient (logP) values were encapsulated in gliadin nanoparticles, with the aim of investigating the influence of their physico-chemical properties on the cargo features and technological characteristics of the protein nanocarriers. The results demonstrate that the chemical structure, solubility and molecular weight of the compounds used are able to dramatically modulate the mean sizes and the entrapment efficiency of gliadin nanoparticles. This demonstrates the importance of a preformulation investigation when a molecule needs to be encapsulated in this type of polymeric carrier.

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Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels

Cited by 21 publications

References 42 publications

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Influence of the Physico-Chemical Properties of Model Compounds on the Mean Sizes and Retention Rate of Gliadin Nanoparticles

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