Evaluation of the Effect of Hyaluronic Acid Mixed With Biphasic Calcium Phosphate on Bone Healing Around Dental Implants (Experimental Study)

Abstract

INTRODUCTION:Biphasic calcium phosphate (BCP) is very widely used as a grafting material around dental implants. The properties of such material can be enhanced by adding interpositional graft materials to enhance osteoinduction. Hyaluronic acid (HyA) is an example of osteopromoting materials that can be added to the BCP to enhance its osteoinductive properties. OBJECTIVES: Histological evaluation of using HyA with BCP on bone healing around dental implants. MATERIALS AND METHODS:This study was a split mouth design. It was conducted on 9 mongrel dogs. The dogs were allocated into two groups: Group A (Study Group): The right side of the mandible received dental implants with biphasic calcium phosphate bone graft mixed with hyaluronic acid following extraction of the mandibular third premolar. Group B (Control Group): The left side of the mandible received dental implants with biphasic calcium phosphate bone graft only following extraction of the mandibular third premolar. Dogs were sacrificed at 2, 4 and 6 weeks postoperatively. Segments containing the implant and bone graft were retrieved with adjacent bone to be prepared for histological examination using Haematoxylin and eosin stain and Trichrome stain. RESULTS: All animals survived well, and remained active and alert all over the course of the experiment. Both groups were characterized by new bone formation. The newly formed bone was more evident in association with group (A). CONCLUSIONS: HyA accelerates the onset of new bone formation when combined with BCP for bone augmentation in the treatment of osseous defects.

Effect of Hyaluronic Acid Gel on Healing of Simple Dental Extraction Sockets: A Pilot Study

“…Our outcomes were in accordance with many studies [2], [16], [18] which concluded that HA enhances and fastens the repair time. Our findings were not corresponding to Mostafa et al [19] and Aebli et al [20] who stated that HA does not have any significant effect on healing time or repair capacity.…”

Volumetric and histological evaluation of Osteon II Collagen with Hyaluronic Acid versus Sticky bone graft in Three Dimensional socket preservation

“…In the present study, Hyaluronic acid was used in mixture with Osteon II collagen in group I to benefit from regenerative proprieties of HyA .This was in the same side of Shammal et al (18) and Aguado et al (19) who stated that HyA has osteoconductive activity; it accelerates the bone regeneration by means of chemo taxis, proliferation and successive differentiation of mesenchyme cells.…”

“…In the same context, several researchers (18,19) reported that Hyaluronic acid (HyA) capable to accelerate the onset of new bone formation when it is added to alloplastic bone graft for bone augmentation of alveolar defects. Where, HyA increases osteoblastic bone formation through increased mesenchymal cell differentiation and migration.…”

Evaluation of Platelet Rich Fibrin Sandwiching technique with mixture of alloplastic bone graft and Hyaluronic Acid in repair of Recurrent Oronasal Fistula

“…These authors had used a mix of growth factors or bone morphogenic proteins with cancellous bone to improve osteogenic capacity of graft In the same context several researchers reported that HyA was capable to accelerate the onset of new bone formation when it is added to alloplastic bone graft for bone augmentation of alveolar defects. Where, HyA increases osteoblastic bone formation through increased mesenchymal cell differentiation and migration and decrease bone graft contamination (24)(25)(26) .…”