Evaluation of subacute bisphenol – A toxicity on male reproductive system

Karnam, S.S.; Ghosh, R. C.; Mondal, Shirsha; Mondal, Mohan

doi:10.14202/vetworld.2015.738-744

Cited by 57 publications

(30 citation statements)

References 37 publications

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“…Sperm concentration is one of the valid indices of male infertility (Rungsung, Khan, Sood, Rampal, & Saini, ), and sperm motility is a necessary function for sperm transport through male reproductive tract (Karnam, Ghosh, Mondal, & Mondal, ). Group III(BPA) showed significant reduction in sperm counts and motility as compared to Group I (C).…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

2017

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Spermatogenesis, a highly coordinated process, is prone to environmental insults which may lead to impaired spermatogenesis or, at worst, infertility. Bisphenol A (BPA) is a well-known global environmental toxicant and a ubiquitous oestrogenic chemical. This study evaluated the role of selenium (0.5 ppm sodium selenite/kg diet) on spermatogenesis after BPA treatment in different groups of male BALB/c mice: control, selenium, BPA and selenium+BPA. Markers of oxidative stress and apoptosis were evaluated in testis after BPA treatment. Significant decrease in sperm concentration and motility and increased reactive oxygen species(ROS) and LPO levels were seen in BPA group. Histopathological changes revealed extensive vacuolisation, lumen devoid of spermatozoa and decreased germ cell count, confirmed by testicular germ cell count studies. TUNEL assay for apoptosis showed increased number of TUNEL-positive germ cells in BPA group with increased percentage apoptotic index. However, in Se+BPA group, histopathological studies revealed systematic array of all germ cells, preserved basement membrane with relatively less vacuolisation, improved sperm parameters and ROS and LPO levels and decreased number of TUNEL-positive germ cells. These results clearly demonstrate the role of selenium in ameliorating oxidative stress and apoptosis induced upon BPA treatment in mice and can be further used as therapeutic target in male infertility.

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Section: Discussionmentioning

confidence: 99%

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

2017

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“…Histopathological findings in the testes showed necrosis of the germinal layer and spermatogonial cells in the seminiferous tubules. Thus, it appears that BPA affects the germ cells leading to impairment in the spermatogenesis and thus having its property as reproductive toxicant 135 . Hass et al, reported that developmental exposure to 25 μg/kg b.w/day bisphenol A that is above the safe level described by the EFSA 136 .…”

Section: Bpa Induced Oxidative Stress and Generation Of Rosmentioning

confidence: 99%

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2019

IJPSR

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Bisphenol-A (BPA), 2,2-bis(4-hydroxyphenyl) propane is an emerging environmental toxicant with endocrine disrupting properties and toxic effects on living organisms. BPA is ubiquitously present in consumer products current in our daily lives. As it is released from consumer products and deposited in the environment, thus creating the potential for human exposure through oral, inhaled, and dermal routes. BPA exposure might be able to cause oxidative damage by disturbing the balance between reactive oxygen species (ROS) and the antioxidant defense system of eukaryotic cells, resulting in the development of oxidative stress-related diseases. From the available information, it can be inferred that a wide variety of BPA intake through any mode results into a generation of reactive oxygen species (ROS), altering the antioxidant balance of eukaryotic cells, induces mitochondrial dysfunction, and affects cell signaling pathways related to oxidative stress. BPA induced oxidative stress might be able to cause sperm damage, mitochondrial dysfunction, and impairment of the structure and function of spermatozoa resulting in male infertility. Here, a review of the current literature examining literature related to BPA exposure, induction of ROS or oxidative stress and concludes that it alters reproductive system functions through induced oxidative stress pathways and negatively affects the fertility of male and females.

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“…Epididymal sperm count was carried out according to previous methods [21,22] with some modifications. Briefly, the left and right caudal epididymides from a rat were removed into two sterile petri dishes.…”

Section: Measurement Of Epididymal Sperm Countmentioning

confidence: 99%

“…Epididymal sperm motility was carried out as described previously [4,23,24]. Briefly, a cut was made at the cauda of the contralateral epididymis.…”

Section: Assessment Of Sperm Motilitymentioning

confidence: 99%

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Assessment of Polyscias fruticosa (L.) Harm (Araliaceae) leaf extract on male fertility in male Wistar rats

Boye¹,

Osei-Owusu²,

Koffuor³

et al. 2018

J Intercult Ethnopharmacol

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Background: Polyscias fruticosa is used widely as food, remedy for diseases, and as an ornamental across Afro-Asian countries. For instance, P. fruticosa is used traditionally as an anti-asthma, anti-tussive, and a muco-suppressant herbal remedy for asthmatics in Ghana. Although many studies have investigated the pharmacological basis of the ethnobotanical uses of P. fruticosa, however, its effect on the reproductive system remains completely unknown. Aim of study: This study assessed effects of P. fruticosa leaf extract (PFE) on male fertility and toxicity in adult male Wistar rats. Materials and methods: After crude preparation of PFE, it was subjected to qualitative phytochemical, thin layer chromatography and gas chromatography mass spectrometry analyses. The effect of PFE was assessed on male fertility and toxicity by using healthy adult male Wistar rats. Rats were randomly assigned to normal saline (5 ml/kg po, n = 5), Clomiphene Citrate (CL; 50 mg/kg po; n = 5), and PFE (100, 200, and 500 mg/kg po; n = 5, respectively) groups and treated for 21 days. On day 22, rats were sacrificed and male fertility parameters (left testis weight, relative testis weight, caudal epididymal weight, caudal epididymal sperm count, sperm motility, sperm morphology, and assessment of male sex hormones and testicular histology) were assessed. Results: There were no significant changes in bodyweight, weight of left testis, weights of right and left caudal epididymides between treatment groups (PFE and CL) and control. Caudal epididymal sperm count increased in PFE (100 and 500 mg/kg)-treated rats relative to control. Sperm motility relatively increased in PFE-treated rats compared to control. Sperm abnormality decreased in PFE-treated rats, especially in PFE (100 mg/kg) group compared to control. Serum testosterone levels decreased inversely with serum luteinizing hormone levels in PFE-treated rats compared to control. There were minimal-to-no-alterations in histological sections of testis, except vacuolations at primary spermatocyte stage. Glycosides, saponins, cyanogenic glycosides, sterols, and alkaloids were detected in PFE. Conclusion: PFE improved caudal epididymal sperm count and may be useful as male fertility enhancer but exhaustive safety studies on key male sex organs needs to be established.

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Evaluation of subacute bisphenol – A toxicity on male reproductive system

Cited by 57 publications

References 37 publications

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

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Assessment of Polyscias fruticosa (L.) Harm (Araliaceae) leaf extract on male fertility in male Wistar rats

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