2015
DOI: 10.14202/vetworld.2015.738-744
|View full text |Cite
|
Sign up to set email alerts
|

Evaluation of subacute bisphenol – A toxicity on male reproductive system

Abstract: Aim:The aim was to evaluate the effect of multiple oral administration of bisphenol A (BPA) for 28 days on seminal characteristic on mammal using Wistar rat as a model.Materials and Methods:Rats were randomly divided into five different groups having 6 male rats in each group. The doses chosen were 50, 200, and 600 mg/kg body weight for Groups III, IV and V, respectively, based on preliminary dose range finding study and Group II served as vehicle control and Group I was negative control.Results:Reproductive s… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
24
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
6
1
1

Relationship

0
8

Authors

Journals

citations
Cited by 57 publications
(30 citation statements)
references
References 37 publications
(30 reference statements)
5
24
0
Order By: Relevance
“…Sperm concentration is one of the valid indices of male infertility (Rungsung, Khan, Sood, Rampal, & Saini, ), and sperm motility is a necessary function for sperm transport through male reproductive tract (Karnam, Ghosh, Mondal, & Mondal, ). Group III(BPA) showed significant reduction in sperm counts and motility as compared to Group I (C).…”
Section: Discussionmentioning
confidence: 99%
“…Sperm concentration is one of the valid indices of male infertility (Rungsung, Khan, Sood, Rampal, & Saini, ), and sperm motility is a necessary function for sperm transport through male reproductive tract (Karnam, Ghosh, Mondal, & Mondal, ). Group III(BPA) showed significant reduction in sperm counts and motility as compared to Group I (C).…”
Section: Discussionmentioning
confidence: 99%
“…Histopathological findings in the testes showed necrosis of the germinal layer and spermatogonial cells in the seminiferous tubules. Thus, it appears that BPA affects the germ cells leading to impairment in the spermatogenesis and thus having its property as reproductive toxicant 135 . Hass et al, reported that developmental exposure to 25 μg/kg b.w/day bisphenol A that is above the safe level described by the EFSA 136 .…”
Section: Bpa Induced Oxidative Stress and Generation Of Rosmentioning
confidence: 99%
“…Epididymal sperm count was carried out according to previous methods [21,22] with some modifications. Briefly, the left and right caudal epididymides from a rat were removed into two sterile petri dishes.…”
Section: Measurement Of Epididymal Sperm Countmentioning
confidence: 99%
“…Epididymal sperm motility was carried out as described previously [4,23,24]. Briefly, a cut was made at the cauda of the contralateral epididymis.…”
Section: Assessment Of Sperm Motilitymentioning
confidence: 99%
See 1 more Smart Citation