Evaluation of serum lipid profile in cases of pre-eclampsia and eclampsia

Abstract

Background: According to the current knowledge, rise in the serum triglyceride level is a major contributor in the pathogenesis of preeclampsia and eclampsia. The present study was designed to compare the changes in lipid profile in normal pregnancy, pre-eclampsia & eclampsia cases. Methods: A case control study was done consisting of total 100 study subjects, 75 already diagnosed pre-eclamptic & eclamptic women and 25 normotensive pregnant women. Age range was 18-35 years, gestational age 28 weeks to term were included. Serum Total Cholesterol (TC), triglyceride and HDL-cholesterol by enzymatic colorimetric method were done. Results: Results showed that level of serum triglycerides in mild pre-eclampsia (156.22 ± 66.5 mg/dl), severe preeclampsia (168.30 ± 68.1 mg/dl) & eclampsia (224.89 ± 84.40 mg/dl) as compared to normal pregnant women (130.95 ± 44.64 mg/dl) was increased significantly (P <0.05). Other parameters TC, HDL-C, LDL-C were not changed significantly. Conclusions: The findings of the present study are consistent with previous studies, suggesting increased levels of serum triglyceride as an important factor in the pathological process of preeclampsia & eclampsia. This may help in developing strategies for prevention or early diagnosis of the disorder.

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

“…The mean serum triglyceride level of the current study was significantly higher in preeclamptic women than normotensive pregnant women (228.04 ± 91.38 and 145.67 ± 121.61), respectively and its pooled SMD was (SMD = 1.61, 95% CI: 1.03, 2.14). Similar, findings were reported in the studies conducted in China and Pakistan [ 36 , 38 , 39 ]. In the prospective cohort study conducted in Netherlands, hypertriglyceridemia were associated with pre-eclampsia and high blood pressure in the early pregnancy [ 40 ].…”

Second Trimester Uterine Artery Doppler Velocimetry and Serum Lipids for Prediction of Pre-Eclampsia

“…Significant rise of serum triglyceride concentrations in our study has been corroborated in various other studies [20,[22][23][24][25] . A 4.15-fold increase in the risk of pre-eclampsia among women with triglyceride levels >133 mg/dL (95% CI 1.50 to 11.49) has been reported by Enquobahrie DA et al [20] .…”

Assessment of Serum Lipid and Uric Acid Levels in Women with Normal Pregnancy and Pre-Eclampsia

“…Numbers of mechanisms have been proposed for the development of pre-eclampsia; though, endothelial dysfunction leading to the oxidative stress and contributing to the altered lipid profile in women with pre-eclampsia have been considered as a significant risk factor in previous studies 6 . It has been suggested that dyslipidemia in the beginning of pregnancy has high risks of pre-eclampsia and eclampsia 7 . Increased serum or plasma triglyceride (TG) concentration greater than 1.6 mmol/l is referred as hypertriglyceridemia.…”