Background: Cancers of the central nervous system (CNS) are considered to be among the most notorious of all cancers. The brain and spinal cord are complex & delicate organs that control the higher functions, the peripheral nervous system, and many of the voluntary and involuntary systems of the body. It has been found that about 1/3 of all cancers metastasize to the brain. Low-grade tumors have been found over time to progress to high grade tumors. Aims & Objectives: The objective of this article is to provide a current overview of the descriptive epidemiology of central nervous system tumors in our hospital set up. Our target was to study incidence of various lesion in light of WHO classification (2007) & study relevant statistics. Materials and Methods: A total of 65 cases of CNS tumors were retrieved from the archives of the Department of Pathology, M.G.M. Medical College, Indore from May 2009 to May 2014. The diagnoses in all the cases were made on hematoxylin & eosin stained slides of processed tissue. Results: In our study, meningioma was the most common lesion followed by astrocytoma. Out of total 65 cases, we came across 27 cases of meningioma and Astrocytoma was in 16 cases. 5 cases of ependymomas were seen. Conclusion: Males are at much higher risk of developing CNS lesion in comparison to females. WHO Grade I lesions were more common in our institutional set up. Astrocytic WHO Grade III lesion was more common in comparison to Grade I lesion indicating need for imaging & neurology consultation at grass root level.

Background: Dermatological disorders are common in all countries but the spectrum varies greatly. While skin diseases are very common among the populations in many developing countries, they have not been regarded as a significant problem, which could benefit from public health measures. Aims & Objective: To analyze the role of histopathology in making the diagnosis of skin lesion. Materials and Methods: In the period of 2009 to 2014, we retrospectively analyzed data of 112 patients. Patient's data were retrieved from the archives of the Department of Pathology, M.G.M. Medical College, Indore. Results: A total of 112 patients were included in the study, 63 cases (56%) were males and 49 cases (44%) were females. In males, the commonest lesions were granulomatous lesions (n-30, 26.80, %) followed by nonspecific dermatoses. In females, the commonest lesions were nonspecific dermatoses (n= 15, 13.6%) & granulomatous lesions (n-18, 16.4%). Conclusion: Skin diseases were more common in males than females. Granulomatous lesions were common in males than females.

Background: Fine needle aspiration cytology (FNAC) is being increasingly used in the diagnosis of salivary gland lesions. However, the diagnosis is still difficult sometimes. Salivary gland lesions account for 2-6.5% of all the neoplasms of the head and neck. The objective of this study was to evaluate the diagnostic accuracy and the sensitivity and specificity of FNAC in various salivary gland lesions and their histological correlation wherever possible.Methods: A total of 123 FNACs were done on salivary gland swellings in the Department of Pathology, M.G.M. Medical College, Indore, Madhya Pradesh, India. The PAP stained cytological and H and E stained histopathological slides were studied and correlated.Results: On FNAC, slides were studied and analyzed and the following lesions were observed: Inflammatory lesion (69), Inflammatory cystic lesion (1), Pleomorphic adenoma (29), monomorphic adenoma (1), Warthin’s tumour (2), Benign Cystic lesion (4), Benign lesion (not specified) (4), Adenoid cystic carcinoma (3), Mucoepidermoid carcinoma (2), Metastatic carcinoma (3), and malignant tumour (unspecified) (5). Histopathological correlation was available in 41 cases and studied respectively.Conclusions: The overall sensitivity, specificity and the diagnostic accuracy were 90.2%, 97.6%, and 90.2%, respectively. Hence, the appropriate therapeutic management could be planned earlier. This study documents that FNAC of the salivary gland tumours is accurate, simple, rapid, inexpensive, well tolerated and harmless procedure for the patient.

Background: According to the current knowledge, rise in the serum triglyceride level is a major contributor in the pathogenesis of preeclampsia and eclampsia. The present study was designed to compare the changes in lipid profile in normal pregnancy, pre-eclampsia & eclampsia cases. Methods: A case control study was done consisting of total 100 study subjects, 75 already diagnosed pre-eclamptic & eclamptic women and 25 normotensive pregnant women. Age range was 18-35 years, gestational age 28 weeks to term were included. Serum Total Cholesterol (TC), triglyceride and HDL-cholesterol by enzymatic colorimetric method were done. Results: Results showed that level of serum triglycerides in mild pre-eclampsia (156.22 ± 66.5 mg/dl), severe preeclampsia (168.30 ± 68.1 mg/dl) & eclampsia (224.89 ± 84.40 mg/dl) as compared to normal pregnant women (130.95 ± 44.64 mg/dl) was increased significantly (P <0.05). Other parameters TC, HDL-C, LDL-C were not changed significantly. Conclusions: The findings of the present study are consistent with previous studies, suggesting increased levels of serum triglyceride as an important factor in the pathological process of preeclampsia & eclampsia. This may help in developing strategies for prevention or early diagnosis of the disorder.

Background: Scrape cytology is quick method to know difference between benign & malignant lesions hence aid in early diagnosis. This can in turn lead to quick management even intra operatively. This diagnostic discipline has arisen in parallel but much before contemporary histology. Aims & Objective: (1) To establish scrape cytology techniques as a routine procedure for diagnosis of surgical specimen; (2) To evaluate the diagnostic accuracy of scrape cytological techniques in the diagnosis; (3) To study the merits and pitfalls of scrape cytological techniques in the diagnosis; (4) Correlations of findings of scrape cytology with histopathological findings. Materials and Methods: This was a prospective study of 100 surgical specimens submitted in Department of Pathology, MGM Medical College, Indore. Smears obtained were stained with Papanicolaou Stain & studied. Results: Out of total 33 benign lesions, 31 (94%) were diagnosed correctly and 1 (3%) was false negative & 1 (3%) was not correlating well with histology. Out of total 67 malignant lesions 60 (89.6%) were diagnosed correctly, 2 (3.0%) were false negative and 5 (7.4%) did not correlated with histology. Conclusion: Scrape cytology is rapid technique for diagnosis & can be utilized in place of frozen section as well as adjuvant to histological diagnosis.