Evaluation of serum fucose level in patients with oral cancer

Ghosh, Madhumita; Raghavan, Meera; Nayak, BL; Bailoor, Durgesh N

doi:10.1016/0030-4220(88)90355-6

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…[1] Different cancers show different rates of incidence and distribution according to geographic parameters. [2] Cancers of the head and neck are heterogeneous group of neoplasms that display a wide range of biologic behaviors. [3] In the Indian subcontinent, it is observed that because of cultural, ethnic, and geographic factors and the popularity of the addictive habits, the frequency of oral cancer is one of the highest in the world.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma

Chinnannavar¹,

Ashok

Vidya³

et al. 2015

J Int Soc Prevent Communit Dent

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Background:Detection of cancer at the early stage is of utmost importance to decrease the morbidity and mortality of the disease. Apart from the conventional biopsy, minimally invasive methods like serum evaluation are used for screening large populations. Thus, this study aimed to estimate serum levels of sialic acid and fucose and their ratio in oral cancer patients and in healthy control group to evaluate their role in diagnosis.Materials and Methods:Serum samples were collected from 52 healthy controls (group I) and 52 squamous cell carcinoma patients (group II). Estimation of serum levels of sialic acid and fucose and their ratio was performed. This was correlated histopathologically with the grades of carcinoma. Statistical analysis was done by using analysis of variance (ANOVA) test and unpaired “t” test.Results:Results showed that serum levels of sialic acid and fucose were significantly higher in oral cancer patients compared to normal healthy controls (P < 0.001). The sialic acid to fucose ratio was significantly lower in cancer patients than in normal controls (P < 0.01). However, comparison with histological grading, habits, gender, and age group did not show any significant result.Conclusion:The mean serum sialic acid and fucose levels showed an increasing trend from controls to malignant group and their corresponding ratio showed decreasing trend from controls to malignant group. The ratio of sialic acid to fucose can be a useful diagnostic aid for oral cancer patients.

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Section: Introductionmentioning

confidence: 99%

Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma

Chinnannavar¹,

Ashok

Vidya³

et al. 2015

J Int Soc Prevent Communit Dent

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“…Similarly, higher serum fucose levels compared with those of the controls have been observed by various other workers. [24][25][26][27][30][31][32] It was observed that there was no relationship of serum fucose levels with age and sex. The findings of the present study were in accordance with those of Sharma and Sur, [20] Arya and Bhatnagar, [21] Solanki et al [22] as well as with other workers.…”

Section: Discussionmentioning

confidence: 99%

“…The level obtained in the present study was very much similar to that obtained by other workers, [20][21][22][23] although slightly higher levels have been obtained by some other workers. [13,[24][25][26][27][28][29][30][31] Oral squamous cell carcinoma patients showed mean serum fucose level of 15.34 ± 0.86 mg%. There was almost threefold rise in the levels from healthy controls to patients.…”

Section: Discussionmentioning

confidence: 99%

Quantitative evaluation of serum fucose in oral squamous cell carcinoma patients

Parwani¹,

Parwani²

2011

J Can Res Ther

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“…In Table 3, we summarize findings from studies comparing serum fucose and fucosylated glycan profiles from healthy individuals vs. breast, oral/head and neck, HCC, ovarian, CRC, pancreatic, lung and prostate cancer patients. Several of these studies suggest diagnostic potential for serum L-fucose levels, which have been found to be elevated in cancer patient sera in breast [53,54,55], oral/head and neck [56,57,58,59,60,61], HCC [62,63,64,65], CRC [66,67], and ovarian [55,68] cancer patients compared with healthy individuals. Specific fucosylated glycoconjugates have been found to also have potential diagnostic utility.…”

Section: Serum Fucose and Fucosylated Glycoconjugatesmentioning

confidence: 99%

The Diverse Contributions of Fucose Linkages in Cancer

Keeley

Yang

Lau

2019

Cancers

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Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.

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Evaluation of serum fucose level in patients with oral cancer

Cited by 8 publications

References 7 publications

Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma

Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma

Quantitative evaluation of serum fucose in oral squamous cell carcinoma patients

The Diverse Contributions of Fucose Linkages in Cancer

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