Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma

Abstract

Background:Detection of cancer at the early stage is of utmost importance to decrease the morbidity and mortality of the disease. Apart from the conventional biopsy, minimally invasive methods like serum evaluation are used for screening large populations. Thus, this study aimed to estimate serum levels of sialic acid and fucose and their ratio in oral cancer patients and in healthy control group to evaluate their role in diagnosis.Materials and Methods:Serum samples were collected from 52 healthy controls (group I) and 52 squamous cell carcinoma patients (group II). Estimation of serum levels of sialic acid and fucose and their ratio was performed. This was correlated histopathologically with the grades of carcinoma. Statistical analysis was done by using analysis of variance (ANOVA) test and unpaired “t” test.Results:Results showed that serum levels of sialic acid and fucose were significantly higher in oral cancer patients compared to normal healthy controls (P < 0.001). The sialic acid to fucose ratio was significantly lower in cancer patients than in normal controls (P < 0.01). However, comparison with histological grading, habits, gender, and age group did not show any significant result.Conclusion:The mean serum sialic acid and fucose levels showed an increasing trend from controls to malignant group and their corresponding ratio showed decreasing trend from controls to malignant group. The ratio of sialic acid to fucose can be a useful diagnostic aid for oral cancer patients.

Estimation of serum sialic acid in oral submucous fibrosis and oral squamous cell carcinoma

“…The present study results were also in accordance with the study conducted by Chinnannavar et al ,[ 3 ] Rajpura et al ,[ 32 ] Xing et al ,[ 33 ] Shashikanth and Rao[ 34 ] Kimura et al ,[ 35 ] Wilma Delphine Silvia et al [ 36 ] and Dhakar et al ,[ 37 ] who reported a significant increase in the mean serum SA levels in OSCC compared to the normal individuals. It has been demonstrated that SA increases at the tumor cell surface, so the increase in their serum levels may be related to their increased release through increased turnover, secretion and shedding.…”

“…Although the oral cavity is frequently examined, 60% of intraoral carcinomas are in advanced stage at the time of detection. [ 3 ] Persistent difficulties arising in oral cancer are late diagnosis, poor response of tumor to chemotherapy, lack of reliable biomarkers for early diagnosis and posttherapeutic monitoring. [ 4 ] Therefore, early detection of oral cancer is of utmost importance for improving the survival rate and prognosis of patients with the disease.…”

Novel serum metabolomics‐based approach by gas chromatography/triple quadrupole mass spectrometry for detection of human skin cancers: Candidate biomarkers

“…Among them, fucose contributed to the discrimination between the skin cancer groups and HV group in PCA. Fucose is a monosaccharide that is usually present in blood as well as in tissue glycoproteins . Some reports suggested that serum fucose levels are elevated in patients with oral SCC .…”

“…Fucose is a monosaccharide that is usually present in blood as well as in tissue glycoproteins . Some reports suggested that serum fucose levels are elevated in patients with oral SCC . Although those studies targeted oral SCC, fucose could be a diagnostic biomarker in patients with SCC.…”

Erratum: Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma

“…In the article titled, “Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma” published in pages 446-450, issue 6, vol. 5 of Journal of International Society of Preventive and Community Dentistry[ 1 ], the affiliation of the third author “Kodige Chandrashekhar Vidya” is incorrectly written as “Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha” instead of “Department of Oral and Maxillofacial Surgery, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha”.…”