Background:Detection of cancer at the early stage is of utmost importance to decrease the morbidity and mortality of the disease. Apart from the conventional biopsy, minimally invasive methods like serum evaluation are used for screening large populations. Thus, this study aimed to estimate serum levels of sialic acid and fucose and their ratio in oral cancer patients and in healthy control group to evaluate their role in diagnosis.Materials and Methods:Serum samples were collected from 52 healthy controls (group I) and 52 squamous cell carcinoma patients (group II). Estimation of serum levels of sialic acid and fucose and their ratio was performed. This was correlated histopathologically with the grades of carcinoma. Statistical analysis was done by using analysis of variance (ANOVA) test and unpaired “t” test.Results:Results showed that serum levels of sialic acid and fucose were significantly higher in oral cancer patients compared to normal healthy controls (P < 0.001). The sialic acid to fucose ratio was significantly lower in cancer patients than in normal controls (P < 0.01). However, comparison with histological grading, habits, gender, and age group did not show any significant result.Conclusion:The mean serum sialic acid and fucose levels showed an increasing trend from controls to malignant group and their corresponding ratio showed decreasing trend from controls to malignant group. The ratio of sialic acid to fucose can be a useful diagnostic aid for oral cancer patients.
Background:The emergence of the blood-borne pathogens and the increasing number of infected patients and the increasing interest in dental health care compel the dental professionals to have thorough knowledge about communicable diseases and the MBBS and nursing students are always at risk because of their profession. As hepatitis B infection is a major health hazard throughout the world, healthcare students should have through knowledge about this disease. Setia et al. had conducted a similar kind of study in Punjab in which the sample size was smaller and it included only the interns, whereas the present study was conducted to assess the level of knowledge, attitude, and behavior about hepatitis B infection among healthcare students of all academic years because they are indulged in clinical work since third year of their curriculum.Materials and Methods:A cross-sectional survey was conducted of all the students starting from 1st year to final year and the interns of MBBS, BDS, and nursing at KIIT University. The questions were obtained from a study performed in Turkey in 2010 and were modified by an infection control expert. Questions in multiple choice format were in English and it was a self-administered questionnaire consisting of three parts (knowledge, attitude, behavior). Then, ethical clearance for the study was obtained from the institutional ethical committee, KIMS. Subsequently, the students were well informed and explained about the study. Students who voluntarily wanted to participate were included in the study. Questionnaire containing 20 questions to assess the level of knowledge, attitude, and behavior about hepatitis B was distributed among the students. Data were compiled and statistical analysis was done.Results:The response rate was 83% (N = 332). In our study, majority (96.99%) were aware of transmission of HBV infection by blood, body fluid, and secretion. The level of knowledge was higher in MBBS students than BDS and nursing students (MBBS > BDS > nursing). Attitude toward the disease was higher in MBBS students than BDS and nursing students (MBBS > BDS > nursing), whereas behavior was higher in BDS students than MBBS and nursing students (BDS > MBBS > nursing).Conclusion:In our study, overall knowledge and attitude toward hepatitis B infection were higher in MBBS students than in dental and nursing students, whereas behavior of dental students toward the disease was quite satisfactory than MBBS and nursing students.
Objectives: The aim of this study was to correlate the clinical grading of oral submucous fibrosis (OSMF) with various habit factors and to observe the habit factors associated with the severity of OSMF. Materials and Methods: This study was carried out in the Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India. Two hundred patients clinically diagnosed with OSMF were included in the study. The observations were tabulated and subjected to statistical analysis using chi-square test and Spearman’s rank correlation test. Results: A total of 200 subjects participated in the study of which 182 were males and 18 were females. Forty-eight males and nine females had Grade I OSMF. One hundred nineteen males and eight females had Grade II OSMF. Fifteen males and only one female had Grade III OSMF. On the basis of functional staging, the total participants in stage I, stage II, and stage III were 185, 14, and 1, respectively. The participants having Grade I, Grade II, and Grade III OSMF with functional staging I were 57, 122, and 6, respectively. The participants having Grade II and Grade III OSMF with functional staging II were 5 and 9, respectively. Conclusion: It is alarming that nearly half of the total subjects were in the younger age group and were having OSMF. Also, as the age increased, the subjects were found to be more attracted to consuming areca nut derivatives in the form of betel quid with or without tobacco. It is recommended that community-oriented outreach programs on oral health awareness be developed, emphasizing children who represent the upcoming future, to avoid/quit areca nut and its derivatives.
Introduction: Lichen planus is a mucocutaneous disease of unknown aetiology. Topical corticosteroid has been widely used for the treatment purpose so far. In order to overcome the side effects of corticosteroid, Photodynamic Therapy (PDT) has been proposed, but very few studies have been done to evaluate the effect of PDT and corticosteroid on lichen planus using computerised photometric analysis. Aim: To compare the efficacy, using computerised photometric analysis and Red Green Blue (RGB) scoring, of triamcinolone acetonide and PDT in the treatment of erosive lichen planus. Materials and Methods: A prospective interventional study was done in the Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India, from January 2021 to February, 2021. There were 10 patients of erosive lichen planus who were divided into two groups. Patients of Group A were treated with Triamcinolone acetonide, and Group B patients were treated with PDT, for four weeks. Visual Analogue Score (VAS), Reticular Erosive Ulcerative (REU) Score, Oral Mucositis Index (OMI), photometric analysis using RGB scoring were recorded at baseline, after two weeks and four weeks of treatment. Mann-Whitney U test was used for intergroup comparison, and paired t-test for intra-group comparison. Results: In the study, there was no significant difference (p-value= 1.00) in age among the patients of two groups. At baseline, VAS mean score of Group A patients (5.20±0.837), Group B patients (6.40±1.140) and the p-value was 0.101; REU mean score of Group A patients (5.90±1.245), Group B patients (9.00±2.00) and p-value was significant (0.028); OMI mean score of Group A patients (1.20±0.447), Group B patients (1.60±0.548) and p-value was 0.221; RGB mean score for Group A (110.80±1.212) and Group B (116.52±1.194). After four weeks of treatment, VAS mean score of Group A patients was (0.80±0.84), Group B patients was 0, p-value was significant (0.05); REU mean score Group A (2.70±1.04), Group B (1.00±0.71), p-value was significant 0.031; OMI mean score of both Group A and B was 0; RGB mean score for Group A (113.22±1.89), Group B (121.58±0.96), p-value was significant (0.009). Conclusion: It was found that PDT was better in treating erosive lichen planus and it can be used as an alternative to the standard treatment modalities.
Objectives: This study was done to assess the effects of pimecrolimus cream 1% and triamcinolone aceonide paste in the treatment of atrophic–erosive oral lichen planus. Materials and Methods: A total of 100 patients diagnosed both clinically and histopathologically as lichen planus were considered in the present study. Subjects were classified into two groups. Group I: Patients in this group were treated with 1% pimecrolimus cream and Group II: Patients falling under this group were treated with triamcinolone acetonide in 0.1% concentration. Results: None of the patients reported worsening clinical signs and symptoms. No significant difference in efficacy and reduction in burning sensation of either pimecrolimus or trimcinolone acetonide was present. Conclusion: Present study found no significant difference in the efficacy of both the agents studied.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.