Quantitative evaluation of serum fucose in oral squamous cell carcinoma patients

Parwani, Rajkumar; Parwani, Simran

doi:10.4103/0973-1482.82928

Cited by 18 publications

(11 citation statements)

References 13 publications

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“…In this study we observed a very high serum fucose in OSMF, Leukoplakia and OC, when compared to controls ( P < 0.001) as like that was observed by Parwani RN et al 28. in their study.…”

Section: Discussionsupporting

confidence: 89%

Quantitative evaluation and correlation of serum glycoconjugates: Protein bound hexoses, sialic acid and fucose in leukoplakia, oral sub mucous fibrosis and oral cancer

Bose

Gokhale

Dwivedi³

et al. 2013

J Nat Sc Biol Med

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Background:Cancer is one of the most common causes of mortality and morbidity today, with more than 10 million new cases and more than 6 million deaths each year worldwide. Globally Oral Cancer is the sixth most common cause of cancer related death. India accounts for 86% of the world's oral cancer cases. Often it proceeds by pre cancerous conditions and lesions. In search for biological markers with diagnostic value, we investigated serum glycoconjugates like protein bound hexoses, fucose and sialic acid in these diseases.Materials and Methods:For this Study 27 newly diagnosed Oral leukoplakia, 27 OSMF and 26 Oral Cancer patients, 40 healthy controls who are non tobacco users and 40 healthy controls who are tobacco users were selected. In all these groups we estimated serum glycoconjugates.Results:We observed no difference in serum glycoconjugates levels between tobacco and non tobacco controls (P > 0.05), but very high levels in oral cancer, Leukoplakia and oral sub mucous fibrosis (OSMF) patients (P < 0.001) when compared to control groups. Fucose levels were significant (P < 0.05) of all the glycoconjugates between OSMF and Leukoplakia.Conclusion:The serum glycoconjugates whose levels were very high in OSMF, Leukoplakia and Oral Cancer, do have a significant diagnostic and prognostic value in these diseases.

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“…In this study we observed a very high serum fucose in OSMF, Leukoplakia and OC, when compared to controls ( P < 0.001) as like that was observed by Parwani RN et al 28. in their study.…”

Section: Discussionsupporting

confidence: 89%

Quantitative evaluation and correlation of serum glycoconjugates: Protein bound hexoses, sialic acid and fucose in leukoplakia, oral sub mucous fibrosis and oral cancer

Bose

Gokhale

Dwivedi³

et al. 2013

J Nat Sc Biol Med

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“…They reported over 2-fold increase in serum glycoprotein L-fucose in patients compared to controls. Findings reported by other researchers are also consistent (29,30). However, according to our best knowledge, this study, for the first time, demonstrates that HNSCC-induced alterations in fucose levels can be also detected in unstimulated whole-mouth saliva.…”

Section: Discussionsupporting

confidence: 90%

Potential role of nuclear magnetic resonance spectroscopy to identify salivary metabolite alterations in patients with head and neck cancer

et al. 2018

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The analysis of the salivary metabolomic profile may offer an early phase approach to assess the changes associated with a wide range of diseases including head and neck cancer. The aim of the present study was to investigate the potential of nuclear magnetic resonance (NMR) spectroscopy for detecting the salivary metabolic changes associated with head and neck squamous cell carcinoma (HNSCC). Unstimulated whole-mouth saliva samples collected from HNSCC patients (primary tumour was located either in the larynx or in the oral cavity) and healthy controls were analysed by 1 H-NMR spectroscopy. Reliably identified salivary metabolites were quantified and the determined concentration values were compared group-wise using a Mann-Whitney U-test. Multivariate discrimination function analysis (DFA) was conducted to identify such a combination of metabolites, when considered together, that gives maximum discrimination between the groups. HNSCC patients exhibited significantly increased concentrations of 1,2-propanediol (P=0.032) and fucose (P=0.003), while proline levels were significantly decreased (P=0.043). In the DFA model, the most powerful discrimination was achieved when fucose, glycine, methanol and proline were considered as combined biomarkers, resulting in a correct classification rate of 92.1%, sensitivity of 87.5% and specificity of 93.3%. To conclude, NMR spectrometric analysis was revealed to be a feasible approach to study the metabolome of saliva that is sensitive to metabolic changes in HNSCC and straightforward to collect in a non-invasive manner. Salivary fucose was of particular interest and therefore, controlled longitudinal studies are required to assess its clinical relevance as a diagnostic biomarker in HNSCC.

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“…Serum fucose level in the present study was significantly found to be elevated among cancer patients (46.63 ± 5.29 mg/dl) when compared to control group (7.22 ± 0.26 mg/dl) as observed by Parwani and Parwani,[ 14 ] Bose et al . [ 15 ] in their study.…”

Section: Discussionsupporting

confidence: 72%

“…In this study, the normal fucose level in the control group is 7.22 ± 0.26 mg/dl. In contrast, to the established normal fucose level by Parwani RN and Parwani SR[ 14 ] was found 5.32 ± 0.67 mg/dl.…”

Section: Discussionmentioning

confidence: 72%

Fucose: A biomarker in grading of oral cancer

Kumar¹,

Saxena²,

Srinivas³

et al. 2015

Natl J Maxillofac Surg

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Introduction:Early diagnosis of cancer helps a great deal in the management of oral cancer patients. Number of proteinous markers have been employed for this purpose. Majority of them are not specific. Recently conjugated oligosaccharide with proteins and lipids have gained considerable importance in the present postgenomics and postproteomic period in the diagnostic and prognostics of cancer cases.Materials and Methods:In this study, serum fucose levels were estimated in 50 control cases and 75 cases of oral cancer by the method of Dische and Shettles as adopted by Winzler.Results:Serum fucose levels were found to be significantly higher in oral cancer cases (46.63 ± 5.29 mg/dl) as compared to the control cases (7.22 ± 0.26 mg/dl). The stepwise elevated serum fucose levels were found to be correlated with the histopathological grading of oral cancer.Conclusions:Estimation of such fucose conjugated proteins is suggestive to be good biomarkers in the diagnosis of oral cancer cases as well as in assessing the prognosis of such cases.

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Quantitative evaluation of serum fucose in oral squamous cell carcinoma patients

Abstract: Serum fucose can be used as an effective diagnostic biomarker in oral squamous cell carcinoma patients.

Cited by 18 publications

References 13 publications

Quantitative evaluation and correlation of serum glycoconjugates: Protein bound hexoses, sialic acid and fucose in leukoplakia, oral sub mucous fibrosis and oral cancer

Quantitative evaluation and correlation of serum glycoconjugates: Protein bound hexoses, sialic acid and fucose in leukoplakia, oral sub mucous fibrosis and oral cancer

Potential role of nuclear magnetic resonance spectroscopy to identify salivary metabolite alterations in patients with head and neck cancer

Fucose: A biomarker in grading of oral cancer

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