In this proof-of-concept study, the administration of pioglitazone led to metabolic and histologic improvement in subjects with nonalcoholic steatohepatitis. Larger controlled trials of longer duration are warranted to assess the long-term clinical benefit of pioglitazone. (ClinicalTrials.gov number, NCT00227110 [ClinicalTrials.gov] .).

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A series of plate-impact spall experiments was conducted to study the spall strength of seven microstructural conditions of aluminum, including three grain sizes of 6061 Al alloy, both ultrapure and commercially pure (1060) polycrystalline aluminum, and single-crystal Al with two different orientations, over the stress range of 4–22 GPa. The pullback velocity, which is a characteristic signature of spall strength, is observed to depend on initial microstructure, impact stress, pulse duration, and loading rate. The pullback velocity generally increases over the stress range of 4–14 GPa and achieves a maximum as the impact stress approaches 22 GPa. The pullback velocity of [100] single-crystal Al is higher than that for both polycrystalline samples and [111] single-crystal samples, indicating that grain orientation strongly affects material response. Experimental results also show that the spall behavior is strongly dependent on sample thickness, while the effect of shock pulse duration was observed to be less significant. Comparison among three 6061 materials indicates that the observed differences depend on initial yield strength. The results also show that initial microstructures and impurities have a diminishing effect on the pullback velocity at stresses near 22 GPa. However, initial properties are observed to have a pronounced effect on the detailed structure of the pullback velocity profile at all stress levels. In particular, an interesting feature, i.e., a sharp slope during pullback followed by a distinct transition to a slower slope, is consistently observed. The occurrence of this change in slope is observed to depend on impact stress, loading rate, and grain size.

Background:Cancer is one of the most common causes of mortality and morbidity today, with more than 10 million new cases and more than 6 million deaths each year worldwide. Globally Oral Cancer is the sixth most common cause of cancer related death. India accounts for 86% of the world's oral cancer cases. Often it proceeds by pre cancerous conditions and lesions. In search for biological markers with diagnostic value, we investigated serum glycoconjugates like protein bound hexoses, fucose and sialic acid in these diseases.Materials and Methods:For this Study 27 newly diagnosed Oral leukoplakia, 27 OSMF and 26 Oral Cancer patients, 40 healthy controls who are non tobacco users and 40 healthy controls who are tobacco users were selected. In all these groups we estimated serum glycoconjugates.Results:We observed no difference in serum glycoconjugates levels between tobacco and non tobacco controls (P > 0.05), but very high levels in oral cancer, Leukoplakia and oral sub mucous fibrosis (OSMF) patients (P < 0.001) when compared to control groups. Fucose levels were significant (P < 0.05) of all the glycoconjugates between OSMF and Leukoplakia.Conclusion:The serum glycoconjugates whose levels were very high in OSMF, Leukoplakia and Oral Cancer, do have a significant diagnostic and prognostic value in these diseases.