Evaluation of Schistosomiasis Mansoni Morbidity by Hepatic and Splenic Elastography

Pereira, Caroline Louise Diniz; Santos, Joelma Carvalho; Arruda, Raissa Melo; Rodrigues, Milena Lima; Siqueira, Eduardo Sampaio; Lemos, Roberto; Batista, Andrea Dória; Domingues, Ana Lúcia Coutinho; Lopes, Edmundo Pessoa de Almeida

doi:10.1016/j.ultrasmedbio.2021.01.022

Cited by 5 publications

(9 citation statements)

References 27 publications

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“…Köpke-Aguiar et al [ 21 ] also reported higher serum levels of GGT in the more severe cases. Pereira et al [ 22 ] and Lambertucci[ 23 ] also reported lower platelets count, as well as increased spleen size in more severe Schistosomiasis mansoni disease.…”

Section: Discussionmentioning

confidence: 99%

“…Significant PPF in the schistosomiasis patients is induced by increase in number of eggs in the intrahepatic portal veins due repeated infections and by the host’s exacerbated immune response[ 24 ]. The presence of adult worms in mesenteric and portal vessels, as well as the presence of their eggs, promotes immunological stimulation and induces primary splenomegaly by reticuloendothelial system hyperplasia, which leads to pancytopenia by hypersplenism[ 19 , 22 ]. Splenomegaly also causes blood hyperflow in the splenic vein, which contributes to presinusoidal portal hypertension[ 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models

Rodrigues¹,

Luz²,

Pereira³

et al. 2022

WJH

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BACKGROUND The evaluation of periportal fibrosis (PPF) is essential for a prognostic assessment of patients with Schistosomiasis mansoni . The WHO Niamey Protocol defines patterns of fibrosis from abdominal ultrasonography, 1 H-nuclear magnetic resonance (NMR)-based metabonomics has been employed to assess liver fibrosis in some diseases. AIM To build 1 H-NMR-based metabonomics models (MM) to discriminate mild from significant periportal PPF and identify differences in the metabolite profiles. METHODS A prospective cross-sectional study was performed on schistosomiasis patients at a University Hospital in Northeastern Brazil. We evaluated 41 serum samples from 10 patients with mild PPF (C Niamey pattern) and 31 patients with significant PPF (D/E/F Niamey patterns). MM were built using partial least squares-discriminant analysis (PLS-DA) and orthogonal projections to latent structures discriminant analysis (OPLS-DA) formalisms. RESULTS PLS-DA and OPLS-DA resulted in discrimination between mild and significant PPF groups with R2 and Q2 values of 0.80 and 0.38 and 0.72 and 0.42 for each model, respectively. The OPLS-DA model presented accuracy, sensitivity, and specificity values of 92.7%, 90.3%, and 100% to discriminate significant PPF. The metabolites identified as responsible by discrimination were: N-acetylglucosamines, alanine, glycolaldehyde, carbohydrates, and valine. CONCLUSION MMs discriminated mild from significant PPF patterns in patients with Schistosomiasis mansoni through identification of differences in serum metabolites profiles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models

Rodrigues¹,

Luz²,

Pereira³

et al. 2022

WJH

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“…В одной из работ показано, что гистологическое исследование подтвердило диагноз шистосомоза -образцы кишечника содержали множественные эозинофильные гранулемы с яйцами S. mansoni [95]. У индивидов, инвазированных S. mansoni, показана эффективность точечной эластографии сдвиговой волной печени и селезенки и соотнесения ее результатов с параметрами УЗИ [96].…”

Section: визуализирующие методыunclassified

Foresight in the diagnosis of trematodiasis: innovations versus routine methods

et al. 2023

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Aim. To analyze modern methods for the diagnosis of trematodiasis in experimental and epidemiological studies.Trematodiasis is a group of common parasitic diseases that are a socially sensitive health problem worldwide. According to World Health Organization, more than 250 million people are affected by trematode infections globally. The most common types of human trematode infections are diseases caused by Schistosoma, Fasciola, Clonorchis, and Opisthorchis pathogens. Diagnosis of trematodiasis is often multistage and includes identification of disease symptoms, analysis of medical history, and use of various laboratory tests. Clinical presentation of parasitic infections often varies, making a definitive diagnosis difficult. Various tools are used to diagnose trematode infections: epidemiological criteria, laboratory tests (complete blood count and blood biochemistry, serological methods), instrumental methods (abdominal X-ray and ultrasound), and parasitological techniques, which often have insufficient sensitivity and specificity. Therefore, development of modern and effective non-invasive methods for detection of trematode infections with high sensitivity and specificity, including screening in endemic regions, is relevant.The present review analyzes the results of 90 clinical trials and experimental studies on the diagnosis of trematode infections using the PubMed search engine and the eLibrary database. The review analyzes original articles published from January 1, 2015 to December 31, 2021.Most studies confirm that the absence of a standard diagnostic approach highlights obvious convenience of utilizing a combined approach to reliable diagnosis of trematodiasis. An adequate combination of different diagnostic tests makes it possible to diagnose the disease correctly, devise a correct treatment and follow-up strategy, and organize preventive measures.

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“…Similarly, an association has also been reported between splenic elastography and signs of portal hypertension, including the presence of esophageal varices, in some chronic liver diseases[ 56 ]. However, these are still initial studies in assessing schistosomiasis portal hypertension[ 52 ].…”

Section: Noninvasive Markers Of Ppfmentioning

confidence: 99%

“…In fact, recent studies have shown that the measurement of spleen stiffness by TE and pSWE correlates with that of liver stiffness and of portal hypertension in patients with HSS[ 20 , 52 ]. Accordingly, spleen stiffness may also be a predictor of variceal bleeding in HSS and may be further investigated for predicting HSS complications[ 57 ].…”

Section: Noninvasive Markers Of Ppfmentioning

confidence: 99%

Noninvasive diagnosis of periportal fibrosis in schistosomiasis mansoni: A comprehensive review

Santos¹,

Pereira²,

Domingues³

et al. 2022

WJH

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Schistosomiasis mansoni is a neglected disease and key public health problem, mainly due to its high prevalence, the scarcity of public policies, and the severity of some clinical forms. Periportal fibrosis (PPF) is the commonest complication of chronic schistosomiasis mansoni and its diagnosis requires different techniques. Even though wedge biopsy of the liver is considered the gold standard, it is not justified in non-surgical patients, and percutaneous liver biopsy may be informative but does not have sufficient sensitivity. Noninvasive PPF tests mostly include biological (serum biomarkers or combined scores) or physical assessments (imaging assessment of fibrosis pattern or tissue stiffness). Moreover, imaging techniques, such as ultrasound, computed tomography, magnetic resonance imaging, and elastography are applied not only to support the diagnosis of schistosomiasis, but also to assess and detect signs of portal hypertension and organ damage due to chronic schistosomiasis. A combination between a comprehensive history and physical examination with biomarkers for liver fibrosis and imaging methods seems to offer the best approach for evaluating these patients. In addition, understanding their strengths and limitations will allow a more accurate interpretation in the clinical context and can lead to greater accuracy in estimating the degree of fibrosis in patients with Schistosomiasis mansoni (S. mansoni) infection. This review will discuss the different noninvasive methods that are currently available for the evaluation of PPF in S. mansoni infection, and their application, advantages, and limitations in clinical practice.

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Evaluation of Schistosomiasis Mansoni Morbidity by Hepatic and Splenic Elastography

Cited by 5 publications

References 27 publications

Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models

Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models

Foresight in the diagnosis of trematodiasis: innovations versus routine methods

Noninvasive diagnosis of periportal fibrosis in schistosomiasis mansoni: A comprehensive review

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