2022
DOI: 10.4254/wjh.v14.i4.696
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Noninvasive diagnosis of periportal fibrosis in schistosomiasis mansoni: A comprehensive review

Abstract: Schistosomiasis mansoni is a neglected disease and key public health problem, mainly due to its high prevalence, the scarcity of public policies, and the severity of some clinical forms. Periportal fibrosis (PPF) is the commonest complication of chronic schistosomiasis mansoni and its diagnosis requires different techniques. Even though wedge biopsy of the liver is considered the gold standard, it is not justified in non-surgical patients, and percutaneous liver biopsy may be informative but does not have suff… Show more

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Cited by 4 publications
(3 citation statements)
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“…Hence, biomarkers tied to liver function cannot be used as a reference standard in the early stages of disease. There is significant motivation to adopt non-invasive methods, and indeed there now seems to be a consensus that ultrasound is the best available reference standard for schistosomal PPF staging [ 29 , 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Hence, biomarkers tied to liver function cannot be used as a reference standard in the early stages of disease. There is significant motivation to adopt non-invasive methods, and indeed there now seems to be a consensus that ultrasound is the best available reference standard for schistosomal PPF staging [ 29 , 30 ].…”
Section: Discussionmentioning
confidence: 99%
“… 5 , 6 Of these, S mansoni is considered a significant public health threat because of its chronic evolution. 7 Unfortunately, there is no vaccine available against human schistosomes. 8 - 10 Praziquantel (PZQ) is the only drug recommended to treat schistosomiasis.…”
Section: Introductionmentioning
confidence: 99%
“…It is estimated that schistosomiasis causes 11,792 deaths worldwide each year [ 3 ]. While there are three primary species that infect humans, S. mansoni is considered a significant public health issue due to its chronic evolution [ 4 ]. Unfortunately, there is currently no vaccine available for human use against S. mansoni [ 5 ].…”
Section: Introductionmentioning
confidence: 99%